{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T12:24:00Z","timestamp":1782563040991,"version":"3.54.5"},"reference-count":154,"publisher":"FapUNIFESP (SciELO)","issue":"2 suppl","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Acad. Bras. Ci\u00eanc."],"abstract":"<jats:p>Brain infection by the fungus Cryptococcus neoformans results in an estimated 500,000 human deaths per annum. Colonization of the central nervous system (CNS) by C. neoformans causes different clinical syndromes that involve interaction of a number of fungal components with distinct brain cells. In this manuscript, our literature review confirmed the notion that the Cryptococcus field is expanding rapidly, but also suggested that studies on neuropathogenesis still represent a small fraction of basic research activity in the field. We therefore discussed anatomical and physiological aspects of the brain during infection by C. neoformans, in addition to mechanisms by which brain resident cells interact with the fungus. This review suggests that multiple efforts are necessary to improve the knowledge on how C. neoformans affects brain cells, in order to enable the generation of new therapeutic tools in a near future.<\/jats:p>","DOI":"10.1590\/0001-3765201520140704","type":"journal-article","created":{"date-parts":[[2015,8,2]],"date-time":"2015-08-02T01:41:36Z","timestamp":1438479696000},"page":"1293-1309","source":"Crossref","is-referenced-by-count":36,"title":["Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis"],"prefix":"10.1590","volume":"87","author":[{"given":"ANA CAROLINE","family":"COLOMBO","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil; Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARCIO L.","family":"RODRIGUES","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil; Funda\u00e7\u00e3o Oswaldo Cruz, 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K","year":"2002","journal-title":"Glia"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2217\/fmb.11.162","article-title":"Research trends on pathogenic Cryptococcus species in the last 20 years: a global analysis with focus on Brazil","volume":"7","author":"ALBUQUERQUE PC","year":"2012","journal-title":"Future Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.cub.2006.09.061","article-title":"Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophages","volume":"16","author":"ALVAREZ M","year":"2006","journal-title":"Curr Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.tim.2014.01.001","article-title":"A neglected epidemic: fungal infections in HIV\/AIDS","volume":"22","author":"ARMSTRONG-JAMES D","year":"2014","journal-title":"Trends Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2003.12.016","article-title":"The blood-brain barrier: an overview: structure, regulation, and clinical implications","volume":"16","author":"BALLABH P","year":"2004","journal-title":"Neurobiol Dis"},{"key":"ref8","first-page":"189","article-title":"Role of the capsule in microglial cell-Cryptococcus neoformans interaction: impairment of antifungal activity but not of secretory functions","volume":"36","author":"BARLUZZI R","year":"1998","journal-title":"Med Mycol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/glia.20477","article-title":"Identification of genes preferentially expressed by microglia and upregulated during cuprizone-induced inflammation","volume":"55","author":"BEDARD A","year":"2007","journal-title":"Glia"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1128\/IAI.60.9.3682-3688.1992","article-title":"Experimental model of intracerebral infection with Cryptococcus neoformans: roles of phagocytes and opsonization","volume":"60","author":"BLASI E","year":"1992","journal-title":"Infect Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1128\/IAI.63.4.1218-1222.1995","article-title":"Biomolecular events involved in anticryptococcal resistance in the brain","volume":"63","author":"BLASI E","year":"1995","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0165-5728(95)00016-U","article-title":"Role of nitric oxide and melanogenesis in the accomplishment of anticryptococcal activity by the BV-2 microglial cell line","volume":"58","author":"BLASI E","year":"1995","journal-title":"J Neuroimmunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2990.1996.tb01111.x","article-title":"Drainage of CSF through lymphatic pathways and arachnoid villi in sheep: measurement of 125I-albumin clearance","volume":"22","author":"BOULTON M","year":"1996","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1055\/s-0031-1295720","article-title":"Pulmonary cryptococcosis","volume":"32","author":"BRIZENDINE KD","year":"2011","journal-title":"Semin Respir Crit Care Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000112102","article-title":"Reactive nitrogen intermediates in human neuropathology: an overview","volume":"16","author":"BROSNAN CF","year":"1994","journal-title":"Dev Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrn3710","article-title":"Microglial phagocytosis of live neurons","volume":"15","author":"BROWN GC","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1128\/IAI.68.2.456-462.2000","article-title":"Requirement for CD4(+) T lymphocytes in host resistance against Cryptococcus neoformans in the central nervous system of immunized mice","volume":"68","author":"BUCHANAN KL","year":"2000","journal-title":"Infect Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/(SICI)1098-1136(19990101)25:1<44::AID-GLIA5>3.0.CO;2-C","article-title":"Identification and functional characterization of the mannose receptor in astrocytes","volume":"25","author":"BURUDI EM","year":"1999","journal-title":"Glia"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1172\/JCI42949","article-title":"Cryptococci at the brain gate: break and enter or use a Trojan horse?","volume":"120","author":"CASADEVALL A","year":"2010","journal-title":"J Clin Invest"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1172\/JCI42949","article-title":"Cryptococci at the brain gate: break and enter or use a Trojan horse?","volume":"120","author":"CASADEVALL A","year":"2010","journal-title":"J Clin Invest"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1128\/IAI.72.9.4985-4995.2004","article-title":"Cryptococcal yeast cells invade the central nervous system via transcellular penetration of the blood-brain barrier","volume":"72","author":"CHANG YC","year":"2004","journal-title":"Infect Immun"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0002-9440(10)62265-1","article-title":"Capsule structure changes associated with Cryptococcus neoformans crossing of the blood-brain barrier","volume":"166","author":"CHARLIER C","year":"2005","journal-title":"Am J Pathol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1128\/IAI.01065-08","article-title":"Evidence of a role for monocytes in dissemination and brain invasion by Cryptococcus neoformans","volume":"77","author":"CHARLIER C","year":"2009","journal-title":"Infect Immun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.idc.2006.07.001","article-title":"Cryptococcosis","volume":"20","author":"CHAYAKULKEEREE M","year":"2006","journal-title":"Infect Dis Clin N Am"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1086\/313992","article-title":"Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand","volume":"31","author":"CHEN S","year":"2000","journal-title":"Australasian Cryptococcal Study Group. Clin Infect Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1099\/jmm.0.05230-0","article-title":"Cryptococcus neoformans induces alterations in the cytoskeleton of human brain microvascular endothelial cells","volume":"52","author":"CHEN SH","year":"2003","journal-title":"J Med Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1086\/341564","article-title":"Pathogenesis of cerebral Cryptococcus neoformans infection after fungemia","volume":"186","author":"CHR\u00c9TIEN F","year":"2002","journal-title":"J Infect Dis"},{"key":"ref28","series-title":"The Cerebral Circulation","author":"CIPOLLA MJ","year":"2009"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1136\/pgmj.20.220.74","article-title":"The Anatomy of the Meninges","volume":"20","author":"CLARKE AG","year":"1944","journal-title":"Postgrad Med J"},{"key":"ref30","first-page":"211","article-title":"Magnetic resonance imaging findings in AIDS patients with central nervous system cryptococcosis","volume":"25","author":"CORTI M","year":"2008","journal-title":"Rev Iberoam Micol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1128\/IAI.00507-12","article-title":"Titan cell production enhances the virulence of Cryptococcus neoformans","volume":"80","author":"CRABTREE JN","year":"2012","journal-title":"Infect Immun"},{"key":"ref32","first-page":"92","article-title":"Meninges: from protective membrane to stem cell niche","volume":"1","author":"DECIMO I","year":"2012","journal-title":"Am J Stem Cells"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0002-9343(91)90126-I","article-title":"Elevated cerebrospinal fluid pressures in patients with cryptococcal meningitis and acquired immunodeficiency syndrome","volume":"91","author":"DENNING DW","year":"1991","journal-title":"Am J Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"176","DOI":"10.7326\/0003-4819-80-2-176","article-title":"Prognostic factors in cryptococcal meningitis","volume":"80","author":"DIAMOND RD","year":"1974","journal-title":"A study in 111 cases. Ann Intern Med"},{"key":"ref35","first-page":"30","article-title":"Microglial nodule encephalitis: limited CNS infection despite disseminated systemic cryptococcosis","volume":"15","author":"EDELMAN M","year":"1996","journal-title":"Clin Neuropathol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1099\/mic.0.032854-0","article-title":"Vesicle-associated melanization in Cryptococcus neoformans","volume":"155","author":"EISENMAN HC","year":"2009","journal-title":"Microbiology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1128\/IAI.68.7.4225-4237.2000","article-title":"Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infection","volume":"68","author":"FELDMESSER M","year":"2000","journal-title":"Infect Immun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.it.2009.11.005","article-title":"Fungal pattern-recognition receptors and tetraspanins: partners on antigen-presenting cells","volume":"31","author":"FIGDOR CG","year":"2010","journal-title":"Trends Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1084\/jem.9.2.142","article-title":"Experimental Cerebro-Spinal Meningitis In Monkeys","volume":"9","author":"FLEXNER S","year":"1907","journal-title":"J Exp Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1128\/IAI.73.3.1779-1787.2005","article-title":"Phenotypic switching of Cryptococcus neoformans can produce variants that elicit increased intracranial pressure in a rat model of cryptococcal meningoencephalitis","volume":"73","author":"FRIES BC","year":"2005","journal-title":"Infect Immun"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3201\/eid1602.090900","article-title":"Epidemiology of Cryptococcus gattii, British Columbia, Canada, 1999-2007","volume":"16","author":"GALANIS E","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s11908-002-0026-y","article-title":"Management of Increased Intracranial Pressure in Cryptococcal Meningitis","volume":"4","author":"GAMBARIN KJ","year":"2002","journal-title":"Curr Infect Dis Rep"},{"key":"ref43","first-page":"759","article-title":"Cryptococcus neoformans meningitis in the rat","volume":"75","author":"GOLDMAN DL","year":"1996","journal-title":"Lab Invest"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1128\/IAI.63.9.3448-3453.1995","article-title":"Tissue localization of Cryptococcus neoformans glucuronoxylomannan in the presence and absence of specific antibody","volume":"63","author":"GOLDMAN DL","year":"1995","journal-title":"Infect Immun"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1086\/313603","article-title":"Diagnosis and management of increased intracranial pressure in patients with AIDS and cryptococcal meningitis. The NIAID Mycoses Study Group and AIDS Cooperative Treatment Groups","volume":"30","author":"GRAYBILL JR","year":"2000","journal-title":"Clin Infect Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s00234-006-0112-1","article-title":"Virchow-Robin spaces on magnetic resonance images: normative data, their dilatation, and a review of the literature","volume":"48","author":"GROESCHEL S","year":"2006","journal-title":"Neuroradiology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"453120","DOI":"10.1155\/2008\/453120","article-title":"Microglia and Astrocyte Activation by Toll-Like Receptor Ligands: Modulation by PPAR-gamma Agonists","volume":"2008","author":"GURLEY C","year":"2008","journal-title":"PPAR Research"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/pr.57.2.4","article-title":"The blood-brain barrier\/neurovascular unit in health and disease","volume":"57","author":"HAWKINS BT","year":"2005","journal-title":"Pharmacol Rev"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1523\/JNEUROSCI.4526-04.2005","article-title":"Isotropic fractionator: a simple, rapid method for the quantification of total cell and neuron numbers in the brain","volume":"25","author":"HERCULANO-HOUZEL S","year":"2005","journal-title":"J Neurosci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/jnr.490280213","article-title":"T-lymphocyte entry into the central nervous system","volume":"28","author":"HICKEY WF","year":"1991","journal-title":"J Neurosci Res"},{"key":"ref51","first-page":"189","article-title":"Fine Structure of Cerebral Fluid Accumulation","volume":"12","author":"HIRANO A","year":"1965","journal-title":"Vi. Intracellular Accumulation of Fluid and Cryptococcal Polysaccharide in Oligodendroglia. Arch Neurol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1099\/jmm.0.05427-0","article-title":"Cryptococcus neoformans infections at Vancouver Hospital and Health Sciences Centre (1997-2002): epidemiology, microbiology and histopathology","volume":"53","author":"HOANG LM","year":"2004","journal-title":"J Med Microbiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1756285609337975","article-title":"Pathophysiology and treatment of bacterial meningitis","volume":"2","author":"HOFFMAN O","year":"2009","journal-title":"Ther Adv Neurol Disord"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e48570","DOI":"10.1371\/journal.pone.0048570","article-title":"Cryptococcus neoformans-derived microvesicles enhance the pathogenesis of fungal brain infection","volume":"7","author":"HUANG SH","year":"2012","journal-title":"PloS one"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3109\/13550289909029748","article-title":"Dissemination of C. neoformans to the central nervous system: role of chemokines, Th1 immunity and leukocyte recruitment","volume":"5","author":"HUFFNAGLE GB","year":"1999","journal-title":"J Neurovirol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0891-0618(01)00122-3","article-title":"D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain","volume":"22","author":"HURD YL","year":"2001","journal-title":"J Chem Neuroanat"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrn1387","article-title":"Neurovascular regulation in the normal brain and in Alzheimer's disease","volume":"5","author":"IADECOLA C","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1172\/JCI67677","article-title":"Brain-wide pathway for waste clearance captured by contrast-enhanced MRI","volume":"123","author":"ILIFF JJ","year":"2013","journal-title":"J Clin Invest"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta","volume":"4","author":"ILIFF JJ","year":"2012","journal-title":"Sci Transl Med"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"e1003439","DOI":"10.1371\/journal.ppat.1003439","article-title":"An acidic microenvironment increases NK cell killing of Cryptococcus neoformans and Cryptococcus gattii by enhancing perforin degranulation","volume":"9","author":"ISLAM A","year":"2013","journal-title":"PLoS Pathog"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4103\/0028-3886.35685","article-title":"Imaging features of central nervous system fungal infections","volume":"55","author":"JAIN KK","year":"2007","journal-title":"Neurol India"},{"key":"ref62","first-page":"507","article-title":"On the mode of entry of blood vessels into the cerebral cortex","volume":"106","author":"JONES EG","year":"1970","journal-title":"J Anat"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s002340000321","article-title":"MRI of a cerebral cryptococcal granuloma","volume":"42","author":"KAMEZAWA T","year":"2000","journal-title":"Neuroradiology"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1177\/1066896908320550","article-title":"Histopathological aspects of neurocryptococcosis in HIV-infected patients: autopsy report of 45 patients","volume":"17","author":"KLOCK C","year":"2009","journal-title":"Int J Sur Pathol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0952-7915(03)00080-3","article-title":"Recognition of microbial infection by Toll-like receptors","volume":"15","author":"KOPP E","year":"2003","journal-title":"Curr Opin Immunol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1148\/rg.274065722","article-title":"Virchow-Robin spaces at MR imaging","volume":"27","author":"KWEE RM","year":"2007","journal-title":"Radiographics"},{"key":"ref67","series-title":"Basic Neurochemistry: Molecular, Cellular and Medical Aspects","volume-title":"Blood-Cerebrospinal Fluid Barrier","author":"LATERRA J","year":"1999","edition":"6"},{"key":"ref68","first-page":"569","article-title":"Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations","volume":"53","author":"LEE G","year":"2001","journal-title":"Pharmacol Rev"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/clinids\/23.1.194","article-title":"Polysaccharide antigen in brain tissue of AIDS patients with cryptococcal meningitis","volume":"23","author":"LEE SC","year":"1996","journal-title":"Clin Infect Dis"},{"key":"ref70","first-page":"1267","article-title":"Immunohistochemical localization of capsular polysaccharide antigen in the central nervous system cells in cryptococcal meningoencephalitis","volume":"148","author":"LEE SC","year":"1996","journal-title":"Am J Pathol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1084\/jem.180.1.365","article-title":"Human astrocytes inhibit Cryptococcus neoformans growth by a nitric oxide-mediated mechanism","volume":"180","author":"LEE SC","year":"1994","journal-title":"J Exp Med"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0046-8177(96)90459-1","article-title":"Pathology of cryptococcal meningoencephalitis: analysis of 27 patients with pathogenetic implications","volume":"27","author":"LEE SC","year":"1996","journal-title":"Hum Pathol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0165-5728(95)00097-L","article-title":"Human microglia mediate anti-Cryptococcus neoformans activity in the presence of specific antibody","volume":"62","author":"LEE SC","year":"1995","journal-title":"J Neuroimmunol"},{"key":"ref74","first-page":"871","article-title":"Cryptococcus neoformans survive and replicate in human microglia","volume":"73","author":"LEE SC","year":"1995","journal-title":"Lab Investigat"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1515\/revneuro-2012-0067","article-title":"The basal ganglia: motor and cognitive relationships in a clinical neurobehavioral context","volume":"24","author":"LEISMAN G","year":"2013","journal-title":"Rev Neurosci"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1939-165X.2010.00281.x","article-title":"Cryptococcosis: update and emergence of Cryptococcus gattii","volume":"40","author":"LESTER SJ","year":"2011","journal-title":"Vet Clin Pathol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00701-009-0311-8","article-title":"Central nervous system cryptococcoma in immunocompetent patients: a short review illustrated by a new case","volume":"152","author":"LI Q","year":"2010","journal-title":"Acta Neurochir"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1074\/jbc.M110.196659","article-title":"Altered immune response in mice deficient for the G protein-coupled receptor GPR34","volume":"286","author":"LIEBSCHER I","year":"2011","journal-title":"J Biol Chem"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1086\/517368","article-title":"Cryptococcal glucuronoxylomannan induces interleukin (IL)-8 production by human microglia but inhibits neutrophil migration toward IL-8","volume":"177","author":"LIPOVSKY MM","year":"1998","journal-title":"J Infect Dis"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1128\/IAI.67.1.108-112.1999","article-title":"Catecholamine oxidative products, but not melanin, are produced by Cryptococcus neoformans during neuropathogenesis in mice","volume":"67","author":"LIU L","year":"1999","journal-title":"Infect Immun"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"e1003247","DOI":"10.1371\/journal.ppat.1003247","article-title":"Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier","volume":"9","author":"LIU TB","year":"2013","journal-title":"PLoS Pathog"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4161\/viru.18685","article-title":"Molecular mechanisms of cryptococcal meningitis","volume":"3","author":"LIU TB","year":"2012","journal-title":"Virulence"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12964-014-0051-0","article-title":"Cryptococcus inositol utilization modulates the host protective immune response during brain infection","volume":"12","author":"LIU TB","year":"2014","journal-title":"Cell Commun Signal"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.nurt.2010.07.002","article-title":"Role of microglia in neurotrauma","volume":"7","author":"LOANE DJ","year":"2010","journal-title":"Neurotherapeutics"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1016\/j.cub.2006.09.032","article-title":"Expulsion of live pathogenic yeast by macrophages","volume":"16","author":"MA H","year":"2006","journal-title":"Curr Biol"},{"key":"ref86","article-title":"Neuroanatomia Funcional","volume":"Paulo","author":"MACHADO ABM","year":"2000","journal-title":"2\u00aa ed., S\u00e3o"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1590\/0004-282X20130153","article-title":"Cerebrospinal fluid analysis in infectious diseases of the nervous system: when to ask, what to ask, what to expect","volume":"71","author":"MACHADO R","year":"2013","journal-title":"Arq Neuro-Psiquatr"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1136\/jnnp.2003.030858","article-title":"Enlarged perivascular spaces are associated with cognitive function in healthy elderly men","volume":"75","author":"MACLULLICH AM","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1128\/IAI.72.4.2338-2349.2004","article-title":"Cytokine and inducible nitric oxide synthase mRNA expression during experimental murine cryptococcal meningoencephalitis","volume":"72","author":"MAFFEI CM","year":"2004","journal-title":"Infect Immun"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1055\/s-0034-1372342","article-title":"New approaches to the diagnosis and treatment of cryptococcal meningitis","volume":"34","author":"MAKADZANGE AT","year":"2014","journal-title":"Semin Neurol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1046\/j.1439-0442.2002.00501.x","article-title":"Central nervous system cryptococcoma in a cat","volume":"49","author":"MANDRIOLI L","year":"2002","journal-title":"J Vet Med A Physiol Pathol Clin Med"},{"key":"ref92","first-page":"1477","article-title":"AIDS-related CNS cryptococcosis: radiologic-pathologic correlation","volume":"13","author":"MATHEWS VP","year":"1992","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1128\/JCM.34.1.218-221.1996","article-title":"D-mannitol in cerebrospinal fluid of patients with AIDS and cryptococcal meningitis","volume":"34","author":"MEGSON GM","year":"1996","journal-title":"J Clin Microbiol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0301-0082(03)00087-X","article-title":"The neurobiology and control of anxious states","volume":"70","author":"MILLAN MJ","year":"2003","journal-title":"Prog Neurobiol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1128\/CMR.8.4.515","article-title":"Cryptococcosis in the era of AIDS - 100 years after the discovery of Cryptococcus neoformans","volume":"8","author":"MITCHELL TG","year":"1995","journal-title":"Clin Microbiol Rev"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.4049\/jimmunol.144.4.1472","article-title":"Depletion of CD4+ (L3T4+) lymphocytes in vivo impairs murine host defense to Cryptococcus neoformans","volume":"144","author":"MODY CH","year":"1990","journal-title":"J Immunol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/NEN.0b013e3182909f2f","article-title":"How does the brain limit the severity of inflammation and tissue injury during bacterial meningitis?","volume":"72","author":"NEAL JW","year":"2013","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"e00103","DOI":"10.1128\/mBio.00103-12","article-title":"The primary target organ of Cryptococcus gattii is different from that of Cryptococcus neoformans in a murine model","volume":"3","author":"NGAMSKULRUNGROJ P","year":"2012","journal-title":"MBio."},{"key":"ref99","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1440-1789.1998.tb00077.x","article-title":"The fundamental architecture of the microvasculature of the basal ganglia and changes in senility","volume":"18","author":"NONAKA H","year":"1998","journal-title":"Neuropathology"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1046\/j.1440-1789.2003.00487.x","article-title":"Microvasculature of the human cerebral meninges","volume":"23","author":"NONAKA H","year":"2003","journal-title":"Neuropathology"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1016\/S0140-6736(00)02356-4","article-title":"Melanisation of Cryptococcus neoformans in human brain tissue","volume":"355","author":"NOSANCHUK JD","year":"2000","journal-title":"Lancet"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1128\/MCB.19.1.745","article-title":"Melanization of Cryptococcus neoformans in murine infection","volume":"19","author":"NOSANCHUK JD","year":"1999","journal-title":"Mol Cell Biol"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/S1471-1931(00)00028-8","article-title":"Pathophysiology of the basal ganglia in Parkinson's disease","volume":"23","author":"OBESO JA","year":"2000","journal-title":"Trends Neurosci"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1128\/EC.00121-12","article-title":"Titan cells confer protection from phagocytosis in Cryptococcus neoformans infections","volume":"11","author":"OKAGAKI LH","year":"2012","journal-title":"Eukaryotic Cell"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"e1000953","DOI":"10.1371\/journal.ppat.1000953","article-title":"Cryptococcal cell morphology affects host cell interactions and pathogenicity","volume":"6","author":"OKAGAKI LH","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/jcbfm.2008.144","article-title":"Characterization of BBB permeability in a preclinical model of cryptococcal meningoencephalitis using magnetic resonance imaging","volume":"29","author":"PAI MP","year":"2009","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/QAD.0b013e328322ffac","article-title":"Estimation of the current global burden of cryptococcal meningitis among persons living with HIV\/AIDS","volume":"23","author":"PARK BJ","year":"2009","journal-title":"Aids"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.fgb.2014.10.003","article-title":"Cryptococcosis diagnosis and treatment: What do we know now","volume":"78","author":"PERFECT JR","year":"2014","journal-title":"Fungal Genet Biol 2015"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1046\/j.1469-7580.1997.19130337.x","article-title":"Perivascular spaces in the basal ganglia of the human brain: their relationship to lacunes","volume":"191( Pt 3)","author":"POLLOCK H","year":"1997","journal-title":"J Anat"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/clinids\/18.5.789","article-title":"Measurement of cryptococcal antigen in serum and cerebrospinal fluid: value in the management of AIDS-associated cryptococcal meningitis","volume":"18","author":"POWDERLY WG","year":"1994","journal-title":"Clin infect Dis"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1590\/S0074-02762009000300019","article-title":"Mortality due to systemic mycoses as a primary cause of death or in association with AIDS in Brazil: a review from 1996 to 2006","volume":"104","author":"PRADO M","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref112","first-page":"206","article-title":"Altered microglial phagocytosis in GPR34-deficient mice","volume":"63","author":"PREISSLER J","year":"2014","journal-title":"Glia 2015"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"786","DOI":"10.3109\/08820139.2011.605196","article-title":"Host defenses against cryptococcosis","volume":"40","author":"PRICE MS","year":"2011","journal-title":"Immunol Invest"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nrn3722","article-title":"Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease","volume":"15","author":"PRINZ M","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1177\/1040638711416624","article-title":"Bovine cryptococcal meningoencephalitis","volume":"23","author":"RIET-CORREA F","year":"2011","journal-title":"J Viet Diagn Invest"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.1128\/IAI.66.10.5027-5030.1998","article-title":"Organ-dependent variation of capsule thickness in Cryptococcus neoformans during experimental murine infection","volume":"66","author":"RIVERA J","year":"1998","journal-title":"Infect Immun"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/infdis\/jit435","article-title":"Cryptococcus neoformans ex vivo capsule size is associated with intracranial pressure and host immune response in HIV-associated cryptococcal meningitis","volume":"209","author":"ROBERTSON EJ","year":"2014","journal-title":"J Infect Dis"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/0091-3057(94)90253-4","article-title":"Dopamine D1 and D2 receptor ligands modulate the behaviour of mice in the elevated plus-maze","volume":"49","author":"RODGERS RJ","year":"1994","journal-title":"Pharmacol Biochem Behav"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0882-4010(02)00195-X","article-title":"Cleavage of human fibronectin and other basement membrane-associated proteins by a Cryptococcus neoformans serine proteinase","volume":"34","author":"RODRIGUES ML","year":"2003","journal-title":"Microbial Pathogenesis"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1128\/IAI.68.5.2845-2853.2000","article-title":"Synthesis of polymerized melanin by Cryptococcus neoformans in infected rodents","volume":"68","author":"ROSAS AL","year":"2000","journal-title":"Infect Immun"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1586\/eri.11.86","article-title":"Preventing deaths from cryptococcal meningitis: from bench to bedside","volume":"9","author":"ROY M","year":"2011","journal-title":"Expert Rev Anti Infect Ther"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"e35455","DOI":"10.1371\/journal.pone.0035455","article-title":"Capsule independent uptake of the fungal pathogen Cryptococcus neoformans into brain microvascular endothelial cells","volume":"7","author":"SABIITI W","year":"2012","journal-title":"PloS one"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1172\/JCI72950","article-title":"Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis","volume":"124","author":"SABIITI W","year":"2014","journal-title":"J Clin Invest"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.anorl.2011.03.002","article-title":"Anatomy and physiology of cerebrospinal fluid","volume":"128","author":"SAKKA L","year":"2011","journal-title":"Eur Ann Otorhinolaringol Head Neck Dis"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1084\/jem.184.2.377","article-title":"Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans","volume":"184","author":"SALAS SD","year":"1996","journal-title":"J Exp Med"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4103\/0028-3886.35683","article-title":"Cryptococcal meningitis: clinical, diagnostic and therapeutic overviews","volume":"55","author":"SATISHCHANDRA P","year":"2007","journal-title":"Neurol India"},{"key":"ref127","first-page":"1103","article-title":"Cerebrospinal fluid analysis","volume":"68","author":"SEEHUSEN DA","year":"2003","journal-title":"Am Fam Physician"},{"key":"ref128","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ijsu.2010.07.293","article-title":"Fungal infections of the nervous system: current perspective and controversies in management","volume":"8","author":"SHARMA RR","year":"2010","journal-title":"Int J Surg (London, England)"},{"key":"ref129","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1172\/JCI41963","article-title":"Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain","volume":"120","author":"SHI M","year":"2010","journal-title":"J Clin Invest"},{"key":"ref130","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1128\/IAI.70.9.5177-5184.2002","article-title":"Fcgamma receptor I- and III-mediated macrophage inflammatory protein 1alpha induction in primary human and murine microglia","volume":"70","author":"SONG X","year":"2002","journal-title":"Infect Immun"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/jcbfm.2012.25","article-title":"Pathophysiology of the neurovascular unit: disease cause or consequence?","volume":"32","author":"STANIMIROVIC DB","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref132","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1046\/j.1471-4159.2000.0750694.x","article-title":"Astrocyte-derived nitric oxide causes both reversible and irreversible damage to the neuronal mitochondrial respiratory chain","volume":"75","author":"STEWART VC","year":"2000","journal-title":"J Neurochem"},{"key":"ref133","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1172\/JCI68241","article-title":"Bathing the brain","volume":"123","author":"STRITTMATTER WJ","year":"2013","journal-title":"J Clin Invest"},{"key":"ref134","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"TAKEDA K","year":"2004","journal-title":"Semin Immunol"},{"key":"ref135","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/nan.12044","article-title":"Fungal encephalitis in human autopsy cases is associated with extensive neuronal damage but only minimal repair","volume":"40","author":"TAUBER SC","year":"2014","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref136","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1620\/tjem.222.33","article-title":"Cryptococcosis in the central nervous system in a 36-year-old Japanese man: an autopsy study","volume":"222","author":"TERADA T","year":"2010","journal-title":"Tohoku J Exp Med"},{"key":"ref137","first-page":"283","article-title":"Intracranial cryptococcosis in immunocompromised patients: CT and MR findings in 29 cases","volume":"12","author":"TIEN RD","year":"1991","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref138","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1073\/pnas.052702799","article-title":"Replication of Cryptococcus neoformans in macrophages is accompanied by phagosomal permeabilization and accumulation of vesicles containing polysaccharide in the cytoplasm","volume":"99","author":"TUCKER SC","year":"2002","journal-title":"Proc Nat Acad Sci USA"},{"key":"ref139","series-title":"White Matter Injury in Stroke and CNS Disease","first-page":"608","volume-title":"White Matter: Basic Principles of Axonal Organization and Function","author":"VELUMIAN A","year":"2013"},{"key":"ref140","series-title":"Astrocytes in (Patho) Physiology of the Nervous System","first-page":"49","volume-title":"Neurotransmitter Receptors in Astrocytes","author":"VERKHRATSKY A","year":"2009"},{"key":"ref141","series-title":"Glial Neurobiology: a textbook","author":"VERKHRATSKY A","year":"2007","edition":"1"},{"key":"ref142","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1590\/0037-8682-0142-2013","article-title":"Soap bubble appearance in brain magnetic resonance imaging: cryptococcal meningoencephalitis","volume":"46","author":"VIEIRA MA","year":"2013","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref143","first-page":"e01101","article-title":"Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease","volume":"5","author":"VU K","year":"2014","journal-title":"MBio."},{"key":"ref144","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF00436496","article-title":"Studies on relationship between cysts and granulomas in murine cryptococcosis","volume":"86","author":"WATABE T","year":"1984","journal-title":"Mycopathologia"},{"key":"ref145","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1586\/ern.10.13","article-title":"Importance of oligodendrocyte protection, blood brain barrier breakdown and inflammation for remyelination","volume":"10","author":"WATZLAWIK J","year":"2010","journal-title":"Expert Rev Neurother"},{"key":"ref146","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev.ps.40.020189.001203","article-title":"Brain dopamine and reward","volume":"40","author":"WISE RA","year":"1989","journal-title":"Annu Rev Psychol"},{"key":"ref147","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/mds.870030312","article-title":"Cryptococcal meningoencephalitis with parkinsonian features","volume":"3","author":"WSZOLEK Z","year":"1988","journal-title":"Mov Disord"},{"key":"ref148","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1177\/0300060513504365","article-title":"Increased permeability of blood-brain barrier is mediated by serine protease during Cryptococcus meningitis","volume":"42","author":"XU CY","year":"2014","journal-title":"J Int Med Res"},{"key":"ref149","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fmicb.2011.00181","article-title":"Multiple Disguises for the Same Party: The Concepts of Morphogenesis and Phenotypic Variations in Cryptococcus neoformans","volume":"2","author":"ZARAGOZA O","year":"2011","journal-title":"Front Microbiol"},{"key":"ref150","doi-asserted-by":"crossref","first-page":"e1000945","DOI":"10.1371\/journal.ppat.1000945","article-title":"Fungal cell gigantism during mammalian infection","volume":"6","author":"ZARAGOZA O","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.mib.2013.03.006","article-title":"Titan cells in Cryptococcus neoformans: cells with a giant impact","volume":"16","author":"ZARAGOZA O","year":"2013","journal-title":"Curr Opin Microbiol"},{"key":"ref152","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0065-2164(09)01204-0","article-title":"The capsule of the fungal 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