{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:30:07Z","timestamp":1792661407735,"version":"4.5.0"},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"2 suppl","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Acad. Bras. Ci\u00eanc."],"abstract":"<jats:p>Several studies have investigated the antinociceptive, immunomodulatory and anti-inflammatory properties of compounds found in the lavender essential oil (LEO), however to date, there is still lack of substantial data. The objective of this study was to assess the antioxidant, anti-inflammatory and antinociceptive effects of lavender essential oil. The 1,1-diphenyl-2-picrylhydrazyl radical decolorization assay was used for antioxidant activity evaluation. The anti-inflammatory activity was tested using two models of acute inflammation: carrageenan-induced pleurisy and croton oil-induced ear edema. The antinociceptive activity was tested using the pain model induced by formalin. LEO has antioxidant activity, which is dose-dependent response. The inflammatory response evoked by carrageenan and by croton oil was reduced through the pre-treatment of animals with LEO. In the pleurisy model, the drug used as positive control, dexamethasone, was more efficacious. However, in the ear swelling, the antiedematogenic effect of the oil was similar to that observed for dexamethasone. In the formalin test, LEO consistently inhibited spontaneous nociception and presented a similar effect to that of tramadol. The results of this study reveal (in vivo) the analgesic and anti-inflammatory activities of LEO and demonstrates its important therapeutic potential.<\/jats:p>","DOI":"10.1590\/0001-3765201520150056","type":"journal-article","created":{"date-parts":[[2015,8,2]],"date-time":"2015-08-02T01:41:52Z","timestamp":1438479712000},"page":"1397-1408","source":"Crossref","is-referenced-by-count":155,"title":["Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil"],"prefix":"10.1590","volume":"87","author":[{"given":"GABRIELA L. DA","family":"SILVA","sequence":"first","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CAROLINA","family":"LUFT","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ADROALDO","family":"LUNARDELLI","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROBSON H.","family":"AMARAL","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia do Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DENIZAR A. DA SILVA","family":"MELO","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00c1RCIO V.F.","family":"DONADIO","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FERNANDA B.","family":"NUNES","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARCOS S. DE","family":"AZAMBUJA","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JO\u00c3O C.","family":"SANTANA","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CRISTINA M.B.","family":"MORAES","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RICARDO O.","family":"MELLO","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EDUARDO","family":"CASSEL","sequence":"additional","affiliation":[{"name":"Universidade Cat\u00f3lica do Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARCOS AUR\u00c9LIO DE ALMEIDA","family":"PEREIRA","sequence":"additional","affiliation":[{"name":"Universidade Cat\u00f3lica do Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JARBAS R. DE","family":"OLIVEIRA","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2015,8,4]]},"reference":[{"key":"ref1","first-page":"1902","article-title":"Identification of essential oils by gas chromatography quadrupole mass spectrometry","volume":"16","author":"ADAMS RP","year":"2001","journal-title":"JASMS"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1021\/np0101245","article-title":"Phenolic constituents and antioxidant activity of an extract ofAnthurium versicolorleaves","volume":"64","author":"AQUINO R","year":"2001","journal-title":"J Nat Prod"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.lfs.2004.08.008","article-title":"Anti-nociceptive and gastroprotective effects of inhaled and orally administeredLavandula hybridaReverchon \"Grosso\" essential oil","volume":"76","author":"BAROCELLI E","year":"2004","journal-title":"Life Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"10550","DOI":"10.1074\/jbc.M708833200","article-title":"Toll-like receptor 4 mediates induction of Bcl10-NFkB-IL-8 inflammatory pathway by carrageenan in human intestinal epithelial cells","volume":"283","author":"BHATTACHARYYA S","year":"2008","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.pbb.2007.05.007","article-title":"Co-administration of rofecoxib and tramadol results in additive or sub-additive interaction during arthritic nociception in rat","volume":"87","author":"GARC\u00cdA-HERN\u00c1NDEZ L","year":"2007","journal-title":"Pharmacol Biochem Behav"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1515\/znc-2002-9-1007","article-title":"The chemical contituents and biological activity ofLavandula stocheasssp. stocheas","volume":"57","author":"G\u00d6REN A","year":"2002","journal-title":"Z Naturforsch"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0378-8741(03)00234-4","article-title":"Anti-inflammatory properties of the leaf extracts and essential oil ofLavandula angustifoliaMill","volume":"89","author":"HAJHASHEMI V","year":"2003","journal-title":"J Ethnopharmacol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1163\/156856003322699591","article-title":"Cox-inhibiting nitric oxide donators (CINODs) - a new paradigm in the treatment of pain and inflammation","volume":"11","author":"HOOGSTRAATE J","year":"2003","journal-title":"Inflammopharmacology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1211\/0022357991772178","article-title":"Lavender oil inhibits immediate-type allergic reaction in mice and rats","volume":"51","author":"KIM HM","year":"1999","journal-title":"J Pharm Pharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/01.shk.0000180074.69143.77","article-title":"Implication of Toll-like receptor and tumor necrosis factor alpha signaling in septic shock","volume":"24","author":"LIN WJ","year":"2005","journal-title":"Shock"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00011-006-0008-x","article-title":"Extract of the bristles of Dirphiasp. increases nitric oxide in a rat pleurisy model.","volume":"55","author":"LUNARDELLI A","year":"2006","journal-title":"Inflamm Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3923\/ijp.2006.50.54","article-title":"Anti-inflammatory and analgesic effects ofPhlomis lanceolataBoiss. and Hojen. Extracts and examination of their components","volume":"2","author":"MOHAJER M","year":"2005","journal-title":"Int J Pharm"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ejphar.2012.10.019","article-title":"The role of PKC\/ERK1\/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice","volume":"698","author":"PASSOS GF","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10753-009-9151-1","article-title":"Anti-inflammatory and immunomodulatory effects ofBaccharis trimeraaqueous extract on induced pleurisy in rats and lymphoproliferation in vitro","volume":"32","author":"PAUL EL","year":"2009","journal-title":"Inflammation"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1078\/094471102321621322","article-title":"Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils","volume":"9","author":"PEANA AT","year":"2002","journal-title":"Phytomedicine"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.lfs.2005.05.065","article-title":"(-)-Linalol inhibits in vitro NO formation: Probable involvement in the anti-nociceptive activity of this monoterprne coumpond","volume":"78","author":"PEANA AT","year":"2006","journal-title":"Life Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/PL00012435","article-title":"Effects of the selective COX-2 inhibitors, celecoxib and rofecoxib in a rat acute model of inflammation","volume":"51","author":"PINHEIRO RM","year":"2002","journal-title":"Inflamm Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev.me.30.020179.000325","article-title":"Biological and enzymatic events in chemical carcinogenisis","volume":"30","author":"PITOT HC","year":"1979","journal-title":"Annu Rev Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.pain.2005.06.011","article-title":"Pronociceptive role of peripheral and spinal 5-HT7 receptors in the formalin test","volume":"117","author":"ROCHA-GONZ\u00c1LEZ HI","year":"2005","journal-title":"Pain"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10753-009-9171-x","article-title":"Anti-inflammatory and immunomodulatory effects ofUlomoides dermestoideson induced pleurisy in rats and lymphoproliferation in vitro","volume":"33","author":"SANTOS RC","year":"2010","journal-title":"Inflammation"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1090-3801(98)90047-7","article-title":"Influence of formalin concentration on the antinociceptive effects of anti-inflammatory drugs in the formalin test in rats: separate mechanisms underlying the nociceptive effects of low- and high-concentration formalin","volume":"2","author":"YASHPAL K","year":"1998","journal-title":"Eur J Pain"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bcp.2006.07.037","article-title":"Prostanoids in nociception and pain","volume":"73","author":"ZEILHOFER HU","year":"2007","journal-title":"Biochem Pharmacol"}],"container-title":["Anais da Academia Brasileira de Ci\u00eancias"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/aabc\/v87n2s0\/0001-3765-aabc-201520150056.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T21:17:01Z","timestamp":1652995021000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0001-37652015000301397&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,4]]},"references-count":22,"journal-issue":{"issue":"2 suppl","published-online":{"date-parts":[[2015,8]]}},"alternative-id":["S0001-37652015000301397"],"URL":"https:\/\/doi.org\/10.1590\/0001-3765201520150056","relation":{},"ISSN":["1678-2690","0001-3765"],"issn-type":[{"value":"1678-2690","type":"electronic"},{"value":"0001-3765","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8,4]]}}}