{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:58:08Z","timestamp":1775080688238,"version":"3.50.1"},"reference-count":43,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Acad. Bras. Ci\u00eanc."],"abstract":"<jats:p>The aim of this study was to evaluate the hepatoprotection of organic and conventional grapevine leaves extract (Vitis labrusca). The total polyphenol content and the isolate polyphenols by HPLC were evaluate. The animals received intraperitoneal injections of saline or extracts (conventional or organic - 30 mg\/kg) for 14 days. On day 15, the rats received carbon tetrachloride (CCl4) or mineral oil (i.p.). After 4h, the animals were euthanized. The analysis of the liver enzymes activity (AST, ALT, GGT) was performed using serum, obtained by blood and the levels of lipid peroxidation (TBARS), protein oxidation (carbonyl), and the activity of antioxidant enzymes superoxide dismutase and catalase were analyzed in the liver. The results showed that the organic extract is richer in polyphenol and resveratrol than the conventional one. Both extracts prevent lipid peroxidation and protein oxidation generated by CCl4. Moreover, the extracts demonstrated ability to modulate the activity of SOD and CAT, as well as to establish a balance in the ratio of SOD\/CAT. We also found that the CCl4 increased the levels of AST and GGT, and that both extracts prevent this. These results indicate that grapevine leaves extracts, both, organic and conventional, can prevent liver disorders.<\/jats:p>","DOI":"10.1590\/0001-3765201620140658","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T22:51:29Z","timestamp":1456959089000},"page":"187-196","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of antioxidant activity of grapevine leaves extracts (Vitis labrusca) in liver of Wistar rats"],"prefix":"10.1590","volume":"88","author":[{"given":"THAYS K.","family":"SCHAFFER","sequence":"first","affiliation":[{"name":"Centro Universit\u00e1rio Metodista, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIANE F.","family":"WOHLENBERG","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Metodista, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NIARA","family":"MEDEIROS","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Metodista, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00c9SSICA B.","family":"MARTINS","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Metodista, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FABIANA","family":"AGOSTINI","sequence":"additional","affiliation":[{"name":"Universidade de Caxias do Sul, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CL\u00c1UDIA","family":"FUNCHAL","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Metodista, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CAROLINE","family":"DANI","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Metodista, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2016,3,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi H","year":"1984","journal-title":"Methods Enzymol"},{"key":"ref2","first-page":"279","article-title":"Assays for SOD","volume":"353","author":"Bannister JV","year":"1987","journal-title":"Methods Biochem Anal"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.clnu.2004.10.003","article-title":"Can oxidative damage be treated nutritionally?","volume":"24","author":"Berger MM","year":"2005","journal-title":"Clin Nutr"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408690290825439","article-title":"A comparison of the nutritional value, sensory qualities and food safety of organically and conventionally produced foods","volume":"42","author":"Bourn D","year":"2002","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"5693","DOI":"10.1021\/jf9014203","article-title":"Screening antioxidants using LC-ms: case study with Cocoa","volume":"57","author":"Calder\u00f3n AI","year":"2009","journal-title":"J Agric Food Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1089\/jmf.2012.0010","article-title":"Serum and Liver Tissue Bio-Element Levels, and Antioxidant Enzyme Activities in Carbon Tetrachloride-Induced Hepatotoxicity: Protective Effects of Royal Jelly","volume":"15","author":"Cemek M","year":"2012","journal-title":"J Med Food"},{"key":"ref7","first-page":"40","article-title":"Experimental cirrhosis induced by carbon tetrachloride inhalation: adaptation of the technique and evaluation of lipid peroxidation","volume":"38","author":"Cremonese RV","year":"2001","journal-title":"Archives of Gastroenterology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/10715760100300331","article-title":"Retinol supplementation induces oxidative stress and modulates antioxidant enzyme activities in rat Sertoli cells","volume":"34","author":"Dal-Pizzol F","year":"2001","journal-title":"Free Radic Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"8994","DOI":"10.1023\/A:1022168805198","article-title":"Modulation of oxidative stress in response to gamma-radiation in human glioma cell lines","volume":"61","author":"Dal-Pizzol F","year":"2003","journal-title":"J Neurooncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/jmf.2007.558","article-title":"Intake of Purple Grape Juice as a Hepatoprotective Agent in Wistar Rats","author":"Dani C","year":"2008","journal-title":"J Med Food"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.tiv.2009.08.006","article-title":"Phenolic content of grapevine leaves (Vitis labrusca var. 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