{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:22:26Z","timestamp":1778714546531,"version":"3.51.4"},"reference-count":60,"publisher":"FapUNIFESP (SciELO)","issue":"suppl 1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Acad. Bras. Ci\u00eanc."],"abstract":"<jats:p>ABSTRACT The objective of this study was to investigate the effects of 2% L-glutamine supplementation on myenteric innervation in the ileum of diabetic rats, grouped as follows: normoglycemic (N); normoglycemic supplemented with L-glutamine (NG); diabetic (D); and diabetic supplemented with L-glutamine (DG). The ileums were subjected to immunohistochemical techniques to localize neurons immunoreactive to HuC\/D protein (HuC\/D-IR) and neuronal nitric oxide synthase enzyme (nNOS-IR) and to analyze varicosities immunoreactive to vasoactive intestinal polypeptide (VIP-IR) and calcitonin gene-related peptide (CGRP-IR). L-Glutamine in the DG group (i) prevented the increase in the cell body area of nNOS-IR neurons, (ii) prevented the increase in the area of VIP-IR varicosities, (iii) did not prevent the loss of HuC\/D-IR and nNOS-IR neurons per ganglion, and (iv) reduced the size of CGRP-IR varicosities. L-Glutamine in the NG group reduced (i) the number of HuC\/D-IR and nNOS-IR neurons per ganglion, (ii) the cell body area of nNOS-IR neurons, and (iii) the size of VIP-IR and CGRP-IR varicosities. 2% L-glutamine supplementation exerted differential neuroprotective effects in experimental diabetes neuropathy that depended on the type of neurotransmitter analyzed. However, the effects of this dose of L-glutamine on normoglycemic animals suggests there are additional actions of this beyond its antioxidant capacity.<\/jats:p>","DOI":"10.1590\/0001-3765201620150228","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T23:45:46Z","timestamp":1461800746000},"page":"609-622","source":"Crossref","is-referenced-by-count":8,"title":["Differential effects in CGRPergic, nitrergic, and VIPergic myenteric innervation in diabetic rats supplemented with 2% L-glutamine"],"prefix":"10.1590","volume":"88","author":[{"given":"RENATA V.F.","family":"PEREIRA","sequence":"first","affiliation":[{"name":"Universidade Estadual de Maring\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID R.","family":"LINDEN","sequence":"additional","affiliation":[{"name":"Mayo Clinic, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARC\u00cdLIO H.","family":"MIRANDA-NETO","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JACQUELINE N.","family":"ZANONI","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2016,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1076\/apab.109.3.246.11587","article-title":"Diabetes mellitus is associated with a decrease in vasoactive intestinal polypeptide content of gastrointestinal tract of rat","volume":"109","author":"Adeghate E","year":"2001","journal-title":"Arch Physiol Biochem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1017\/S1740925X11000093","article-title":"Roles of glutamine in neurotransmission","volume":"6","author":"Albrecht 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