{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:21:05Z","timestamp":1789701665868,"version":"4.0.1"},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Acad. Bras. Ci\u00eanc."],"abstract":"<jats:p>ABSTRACT Mangroves represent areas of high biological productivity and it is a region rich in bioactive substances used in medicine production. Conocarpus erectus (Combretaceae) known as button mangrove is one of the species found in mangroves and it is used in folk medicine in the treatment of anemia, catarrh, conjunctivitis, diabetes, diarrhea, fever, gonorrhea, headache, hemorrhage, orchitis, rash, bumps and syphilis. The present study aimed to investigate the acute toxicity of aqueous extract of leaves of C. erectus in Swiss albino mice. The plant material was collected in Vila Velha mangroves, located in Itamarac\u00e1 (PE). The material was subjected to a phytochemical screening where extractive protocols to identify majority molecules present in leaves were used. The evaluation of acute toxicity of aqueous extract of C. erectus followed the model of Acute Toxicity Class based on OECD 423 Guideline, 2001. The majority molecules were identified: flavonoids, tannins and saponins. The LD50 was estimated at 2,000 mg\/kg bw. Therefore, the aqueous extract showed low acute toxicity classified in category 5.<\/jats:p>","DOI":"10.1590\/0001-3765201620150391","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T10:38:22Z","timestamp":1470220702000},"page":"1431-1437","source":"Crossref","is-referenced-by-count":30,"title":["Phytochemical Screening and Acute Toxicity of Aqueous Extract of Leaves of Conocarpus erectus Linnaeus in Swiss Albino Mice"],"prefix":"10.1590","volume":"88","author":[{"given":"DAYANE K.D.","family":"NASCIMENTO","sequence":"first","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IVONE A. DE","family":"SOUZA","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANT\u00d4NIO F.M. DE","family":"OLIVEIRA","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIANA O.","family":"BARBOSA","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARLLON A.N.","family":"SANTANA","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DANIEL F.","family":"PEREIRA J\u00daNIOR","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EDUARDO C.","family":"LIRA","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JEYMESSON R.C.","family":"VIEIRA","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2016,8,4]]},"reference":[{"key":"ref1","first-page":"52","article-title":"Protective Effect of Conocarpus erectus Extracts on CCl 4-Induced Chronic Liver Injury in Mice","volume":"7","author":"Abdel-Hameed ES","year":"2013","journal-title":"Global J Pharm"},{"key":"ref2","first-page":"93","article-title":"Phytochemical Studies and Evaluation of Antioxidant, Anticancer and Antimicrobial Properties of Conocarpus erectus L. 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