{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:39:44Z","timestamp":1790692784069,"version":"4.1.0"},"reference-count":62,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Acad. Bras. Ci\u00eanc."],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1590\/0001-3765201620150685","type":"journal-article","created":{"date-parts":[[2016,9,10]],"date-time":"2016-09-10T21:17:25Z","timestamp":1473542245000},"page":"1485-1499","source":"Crossref","is-referenced-by-count":36,"title":["Macrophages as target cells for Mayaro virus infection: involvement of reactive oxygen species in the inflammatory response during virus replication"],"prefix":"10.1590","volume":"88","author":[{"given":"MARIANA G.","family":"CAVALHEIRO","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LEANDRO SILVA DA","family":"COSTA","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HOLMES S.","family":"CAMPOS","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LET\u00cdCIA S.","family":"ALVES","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IRANAIA","family":"ASSUN\u00c7\u00c3O-MIRANDA","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDREA T. DA","family":"POIAN","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1371\/journal.pntd.0001846","article-title":"Mayaro Virus Infection in Amazonia: A Multimodel Inference Approach to Risk Factor assessment","volume":"6","author":"ABAD-FRANCH F","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.4269\/ajtmh.1957.6.1012","article-title":"Mayaro virus: a new human disease agent. II. Isolation from blood of patients in Trinidad, B.W.I","volume":"6","author":"ANDERSON C","year":"1957","journal-title":"Am J Trop Med Hyg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/jmv.21649","article-title":"Proinflammatory response resulting from Sindbis virus infection of human macrophages: implications for the pathogenesis of viral arthritis","volume":"82","author":"ASSUNC\u00c3O-MIRANDA I","year":"2010","journal-title":"J Med Virol"},{"key":"ref4","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/973516","article-title":"Molecular mechanisms involved in the pathogenesis of alphavirus-induced arthritis","volume":"2013","author":"ASSUN\u00c7\u00c3O-MIRANDA I","year":"2013","journal-title":"Biomed Res Int"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.3201\/eid1511.090461","article-title":"Mayaro fever virus","volume":"15","author":"AZEVEDO RS","year":"2009","journal-title":"Brazilian Amazon Emerg Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.4269\/ajtmh.1957.6.1017","article-title":"Mayaro virus: a new human disease agent. III. Investigation of an epidemic of acute febrile illness on the river Guama in Para, Brazil, and isolation of Mayaro virus as causative agent","volume":"6","author":"CAUSEY OR","year":"1957","journal-title":"Am J Trop Med Hyg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6040","DOI":"10.1073\/pnas.1318859111","article-title":"Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss","volume":"111","author":"CHEN W","year":"2014","journal-title":"Proc Natl Acad Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0973-3698(11)60023-X","article-title":"Persistent rheumatic musculoskeletal pain and disorders at one year post-chikungunya epidemic in south Maharashtra-a rural community based observational study with special focus on na\u00efve persistent rheumatic musculoskeletal cases and selected cytokine expression","volume":"6","author":"CHOPRA A","year":"2011","journal-title":"Indian J Rheumatol"},{"key":"ref9","first-page":"476","article-title":"Exanthematous diseases and the first epidemic of dengue to occur in Manaus, Amazonas State, Brazil, during 1998-1999","volume":"37","author":"DE FIGUEIREDO RM","year":"2004","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092813","article-title":"Characterization of Chikungunya Virus Induced Host Response in a Mouse Model of Viral Myositis","volume":"9","author":"DHANWANI R","year":"2014","journal-title":"PLoS one"},{"issue":"1","key":"ref11","first-page":"55","article-title":"Anti-TNF therapy: past, present and future","volume":"27","author":"FELDMANN M","year":"2014","journal-title":"Int Immunol"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1590\/0037-8682-0246-2014","article-title":"Emerging alphaviruses in the Americas: Chikungunya and Mayaro","volume":"47","author":"FIGUEIREDO ML","year":"2014","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000787","article-title":"NMRCD Febrile Surveillance Working Group: Arboviral etiologies of acute febrile illnesses in Western South America, 2000-2007","volume":"4","author":"FORSHEY BM","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3201\/eid2007.140043","article-title":"Genome Analysis of Mayaro Virus Imported to Germany from French Guiana","volume":"20","author":"FRIEDRICH-J\u00c4NICKE B","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1128\/JVI.02603-09","article-title":"Chikungunya virus arthritis in adult wild-type mice","volume":"84","author":"GARDNER J","year":"2010","journal-title":"J Virol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.3201\/eid1911.130777","article-title":"Mayaro virus infection, Amazon basin region, Peru, 2010-2013","volume":"19","author":"HALSEY ES","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/ni.2159","article-title":"Programmed necrosis: backup to and competitor with apoptosis in the immune system","volume":"12","author":"HAN J","year":"2011","journal-title":"Nat Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jinf.2010.06.009","article-title":"Imported Mayaro virus infection in The Netherlands","volume":"61","author":"HASSING R","year":"2010","journal-title":"J Infect"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5903","DOI":"10.4049\/jimmunol.0904181","article-title":"Active Infection of Human Blood Monocytes by Chikungunya Virus Triggers an Innate Immune Response","volume":"184","author":"HER Z","year":"2010","journal-title":"J Immunol"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.4049\/jimmunol.0900255","article-title":"Persistent Chronic Inflammation and Infection by Chikungunya Arthritogenic Alphavirus in Spite of a Robust Host Immune Response","volume":"184","author":"HOARAU JJ","year":"2010","journal-title":"J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"689","DOI":"10.4269\/ajtmh.1981.30.689","article-title":"An outbreak of Mayaro virus disease in Belterra, Brazil. III. Entomological and ecological studies","volume":"30","author":"HOCH AL","year":"1981","journal-title":"Am J Trop Med Hyg"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1742-2094-8-123","article-title":"Reactive oxygen species drive herpes simplex virus (HSV)-1-induced proinflammatory cytokine production by murine microglia","volume":"8","author":"HU S","year":"2011","journal-title":"J Neuroinflam"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1084\/jem.20110996","article-title":"Chikungunya virus-induced autophagy delays caspase-dependent cell death","volume":"209","author":"JOUBERT PE","year":"2012","journal-title":"J Exp Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.imlet.2014.10.010","article-title":"The innate immune response","volume":"162","author":"KOENDERMAN L","year":"2014","journal-title":"Immunol Lett"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1096\/fj.10-164178","article-title":"Chikungunya virus mobilizes the apoptotic machinery to invade host cell defenses","volume":"25","author":"KREJBICH-TROTOT P","year":"2011","journal-title":"FASEB J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1186\/1743-422X-9-313","article-title":"Mouse macrophage innate immune response to Chikungunya virus infection","volume":"9","author":"KUMAR S","year":"2012","journal-title":"Virol J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1172\/JCI40104","article-title":"Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages","volume":"120","author":"LABADIE K","year":"2010","journal-title":"J Clin Invest"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.virusres.2005.11.006","article-title":"Mayaro virus: complete nucleotide sequence and phylogenetic relationships with other alphaviruses","volume":"117","author":"LAVERGNE A","year":"2006","journal-title":"Vir Res"},{"issue":"1-2","key":"ref29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/08830180490265529","article-title":"Alphaviruses and apoptosis","volume":"23","author":"LI ML","year":"2004","journal-title":"Int Rev Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"8376","DOI":"10.1128\/JVI.74.18.8376-8381.2000","article-title":"Specific ablation of antiviral gene expression in macrophages by antibody-dependent enhancement of Ross River virus infection","volume":"74","author":"LIDBURY BA","year":"2000","journal-title":"J Virol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"5651","DOI":"10.1128\/JVI.01189-10","article-title":"Identification and characterization of a ross river virus variant that grows persistently in macrophages, shows altered disease kinetics in a mouse model, and exhibits resistance to type I interferon","volume":"85","author":"LIDBURY BA","year":"2011","journal-title":"J Virol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1086\/587841","article-title":"Macrophage derived proinflammatory factors contribute to the development of arthritis and myositis after infection with an arthrogenic alphavirus","volume":"197","author":"LIDBURY BA","year":"2008","journal-title":"J Infect Dis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1083\/jcb.131.5.1149","article-title":"Thiol agents and Bcl-2 identify an alphavirus-induced pathway that requires activation of the transcription factor NF-\u03baB","volume":"131","author":"LIN KI","year":"1995","journal-title":"J Cell Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"750","DOI":"10.4269\/ajtmh.2011.11-0359","article-title":"Experimental transmission of Mayaro virus by Aedes aegypti","volume":"85","author":"LONG KC","year":"2011","journal-title":"Am J Trop Med Hyg"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/cr.2008.31","article-title":"TNF\u03b1 and reactive oxygen species in necrotic cell death","volume":"18","author":"MORGAN MJ","year":"2008","journal-title":"Cell Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ajpath.2010.11.018","article-title":"A mouse model of Chikungunya virus-induced musculoskeletal inflammatory disease: evidence of arthritis, tenosynovitis, myositis, and persistence","volume":"178","author":"MORRISON TE","year":"2011","journal-title":"Am J Pathol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1128\/JVI.80.2.737-749.2006","article-title":"Characterization of Ross River virus tropism and virus-induced inflammation in a mouse model of viral arthritis and myositis","volume":"80","author":"MORRISON TE","year":"2006","journal-title":"J Virol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1089\/vbz.2011.0669","article-title":"Mayaro Fever in the City of Manaus, Brazil, 2007-2008","volume":"16","author":"MOUR\u00c3O MPG","year":"2012","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1590\/0037-8682-0133-2013","article-title":"Arboviral diseases in the Western Brazilian Amazon: a perspective and analysis from a tertiary health & research center in Manaus, State of Amazonas","volume":"48","author":"MOUR\u00c3O MP","year":"2015","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref40","first-page":"1","article-title":"Chikungunya in the Caribbean: An Epidemic in the Making","author":"MOWATT L","year":"2014","journal-title":"J Infect Dis Ther"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00281-008-0120-9","article-title":"NOX enzymes and Toll-like receptor signaling","volume":"30","author":"OGIER-DENIS E","year":"2008","journal-title":"Semin Immunopathol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.micinf.2011.12.008","article-title":"Expression profile of immune response genes during acute myopathy induced by chikungunya virus in a mouse model","volume":"14","author":"PATIL DR","year":"2012","journal-title":"Microb Infect"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"674","DOI":"10.4269\/ajtmh.1981.30.674","article-title":"An Outbreak of Mayaro Virus Disease in Belterra, Brazil: I. Clinical and Virological Findings","volume":"30","author":"PINHEIRO FP","year":"1981","journal-title":"Am J Trop Med Hyg"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"13422","DOI":"10.1074\/jbc.271.23.13422","article-title":"Role of oxidants and antioxidants in the induction of AP-1, NF-kappaB, and glutathione S-transferase gene expression","volume":"271","author":"PINKUS R","year":"1996","journal-title":"J Biol Chem"},{"key":"ref45","article-title":"Multiple Immune Factors Are Involved in Controlling Acute and Chronic Chikungunya Virus Infection","volume":"8","author":"POO YS","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"19563","DOI":"10.2807\/ese.15.18.19563-en","article-title":"Infection with Mayaro virus in a French traveller returning from the Amazon region, Brazil, January, 2010","volume":"15","author":"RECEVEUR M","year":"2010","journal-title":"Euro Surveill"},{"key":"ref47","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/467452","article-title":"RNA Viruses: ROS-Mediated Cell Death","volume":"2014","author":"RESHI ML","year":"2014","journal-title":"Int J Cell Biol"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033871","article-title":"Mitochondrial Bioenergetic Alterations in Mouse Neuroblastoma Cells Infected with Sindbis Virus: Implications to Viral Replication and Neuronal Death","volume":"7","author":"SILVA DA COSTA L","year":"2012","journal-title":"PLoS ONE"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1590\/S0102-311X2006000600021","article-title":"The Acre Project: the epidemiology of malaria and arthropodborne virus infections in a rural Amazonian population","volume":"22","author":"SILVA-NUNES M","year":"2006","journal-title":"Cad Saude Publica"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jcv.2014.04.020","article-title":"Persisting arthralgia due to Mayaro virus infection in a traveler from Brazil: Is there a risk for attendants to the 2014 FIFA World Cup?","volume":"60","author":"SLEGERS CAD","year":"2014","journal-title":"J Clin Virol"},{"issue":"6","key":"ref51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000930","article-title":"Requirement of NOX2 and Reactive Oxygen Species for Efficient RIG-I-Mediated Antiviral Response through Regulation of MAVS Expression","volume":"6","author":"SOUCY-FAULKNER A","year":"2010","journal-title":"PLoS Pathogens"},{"issue":"8","key":"ref52","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.4049\/jimmunol.1201240","article-title":"Genetic Ablation of Arginase 1 in Macrophages and Neutrophils Enhances Clearance of an Arthritogenic Alphavirus","volume":"189","author":"STOERMER KA","year":"2012","journal-title":"J Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nrrheum.2012.64","article-title":"Arthritogenic alphaviruses--an overview","volume":"8","author":"SUHRBIER A","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"452","DOI":"10.4269\/ajtmh.1998.59.452","article-title":"Mayaro virus fever in French Guiana: isolation, identification, and seroprevalence","volume":"59","author":"TALARMIN A","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"ref55","first-page":"1","article-title":"Serologic survey for yellow fever and other arboviruses among inhabitants of Rio Branco, Brazil, before and three months after receiving the yellow fever 17D vaccine","volume":"37","author":"TAVARES-NETO J","year":"2004","journal-title":"Rev Soc Bras Med Trop"},{"issue":"2","key":"ref56","doi-asserted-by":"crossref","first-page":"401","DOI":"10.4269\/ajtmh.14-0417","article-title":"Isolation and characterization of Mayaro virus from a human in Acre, Brazil","volume":"92","author":"TERZIAN AC","year":"2015","journal-title":"Am J Trop Med Hyg"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1186\/1471-2334-13-369","article-title":"Prolonged polyarthralgia in a German traveller with Mayaro virus infection without inflammatory correlates","volume":"13","author":"THEILACKER C","year":"2013","journal-title":"BMC Infect Dis"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.3201\/eid1007.030860","article-title":"Family cluster of Mayaro fever, Venezuela","volume":"10","author":"TORRES JR","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bbagen.2004.12.008","article-title":"Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells","volume":"1722","author":"VEJRA\u017dKA M","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.actatropica.2015.03.020","article-title":"Detection of Mayaro virus infections during a dengue outbreak in Mato Grosso, Brazil","volume":"147","author":"VIEIRA CJ","year":"2015","journal-title":"Acta Trop"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1006\/viro.2002.1587","article-title":"Persistent Ross River Virus Infection of Murine Macrophages: an in Vitro Model for the Study of Viral Relapse and Immune Modulation during Long-Term Infection","volume":"301","author":"WAY SRJ","year":"2002","journal-title":"Virology"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1590\/0074-0276140108","article-title":"Molecular detection of Mayaro virus during a dengue outbreak in the state of Mato Grosso, Central-West Brazil","volume":"109","author":"ZUCHI N","year":"2014","journal-title":"Mem Inst Oswaldo Cruz"}],"container-title":["Anais da Academia Brasileira de Ci\u00eancias"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/aabc\/v88n3\/1678-2690-aabc-88-03-01485.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T03:27:40Z","timestamp":1657250860000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0001-37652016000401485&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0001-37652016000401485"],"URL":"https:\/\/doi.org\/10.1590\/0001-3765201620150685","relation":{},"ISSN":["0001-3765"],"issn-type":[{"value":"0001-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9]]}}}