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M","year":"2010","journal-title":"Biol Psychiatry"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.biopsych.2012.05.003","article-title":"Ketamine for depression: where do we go from here?","volume":"72","author":"ROT M","year":"2012","journal-title":"Biol Psychatry"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s00702-010-0507-3","article-title":"The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis","volume":"117","author":"RUNDFELDT C","year":"2010","journal-title":"J Neural Transm"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/sj.mp.4001682","article-title":"Dopamine receptor contribution to the action of PCP, LSD and ketamine psychotomimetics","volume":"10","author":"SEEMAN P","year":"2005","journal-title":"Mol Psychiatry"},{"key":"ref80","series-title":"Brain Res Bull","first-page":"9","volume":"83","author":"SILVA FCC","year":"2010"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuroscience.2012.03.052","article-title":"Antidepressant-like effects of low ketamine dose is associated with increased hippocampal AMPA\/NMDA receptor density ratio in female Wistar-Kyoto rats","volume":"213","author":"TIZABI Y","year":"2012","journal-title":"Neurosci"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/BF02244869","article-title":"The disruptive effects of ketamine on passive avoidance learning in mice: involvement of dopaminergic mechanism","volume":"116","author":"UCHIHASHI Y","year":"1994","journal-title":"Psychopharmacol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0091-3057(95)02131-0","article-title":"Indirect dopamine agonists effects on despair test: dissociation from hyperactivity","volume":"54","author":"VAUGEOIS J","year":"1996","journal-title":"Pharmacol Biochem Behav"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1177\/0269881107082898","article-title":"Effects of acute or 3-day treatments of Hypericum caprifoliatum Cham. & Schltdt. (Guttiferae) extract or of two established antidepressants on basal and stress-induced increase in serum and brain corticosterone levels","volume":"22","author":"VIANA AF","year":"2008","journal-title":"J Psychopharmacol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.neuropharm.2005.06.002","article-title":"The antidepressant-like effect of Hypericum caprifoliatum Cham & Schlecht (Guttiferae) on forced swimming test results from an inhibition of neuronal monoamine uptake","volume":"49","author":"VIANA AF","year":"2005","journal-title":"Neuropharmacol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.neuroscience.2006.02.062","article-title":"Ketamine affects memory consolidation: differential effects in t-maze and passive avoidance paradigms in mice","volume":"140","author":"WANG JH","year":"2006","journal-title":"Neurosci"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/0278-5846(90)90073-P","article-title":"Neurobehavioral studies of forced swimming: the role of learning and memory in the forced swim test","volume":"14","author":"WEST AP","year":"1990","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"ref88","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/175619","article-title":"Tramadol pretreatment enhances ketamine-induced antidepressant effects and increases mammalian target of rapamycin in rat hippocampus and prefrontal cortex","volume":"2012","author":"YANG C","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.neuron.2011.12.033","article-title":"Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex","volume":"73","author":"YUEN EY","year":"2012","journal-title":"Neuron"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature17998","article-title":"NMDAR inhibition-independent antidepressant actions of ketamine metabolites","volume":"533","author":"ZANOS P","year":"2016","journal-title":"Nature"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","article-title":"A randomized trial on an N-methyl-D-aspartate antagonist in treatment-resistant major depression","volume":"63","author":"ZARATE JR CA","year":"2006","journal-title":"Arch Gen Psychiatry"}],"container-title":["Anais da Academia Brasileira de Ci\u00eancias"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/aabc\/v89n3\/0001-3765-aabc-201720160844.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T04:06:41Z","timestamp":1659326801000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0001-37652017000401655&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":91,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,9]]}},"alternative-id":["S0001-37652017000401655"],"URL":"https:\/\/doi.org\/10.1590\/0001-3765201720160844","relation":{},"ISSN":["1678-2690","0001-3765"],"issn-type":[{"value":"1678-2690","type":"electronic"},{"value":"0001-3765","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]}}}