{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:30:07Z","timestamp":1761514207492},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"1 suppl 2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Acad. Bras. Ci\u00eanc."],"DOI":"10.1590\/0001-3765201820170820","type":"journal-article","created":{"date-parts":[[2018,5,19]],"date-time":"2018-05-19T20:42:55Z","timestamp":1526762575000},"page":"1215-1231","source":"Crossref","is-referenced-by-count":10,"title":["2,3,8-Trisubstituted Quinolines with Antimalarial Activity"],"prefix":"10.1590","volume":"90","author":[{"given":"PABLO D.G.","family":"MARTINEZ","sequence":"first","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUSANN H.","family":"KRAKE","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAITIA L.","family":"POGGI","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SIMON F.","family":"CAMPBELL","sequence":"additional","affiliation":[{"name":"ICC,  Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL A.","family":"WILLIS","sequence":"additional","affiliation":[{"name":"ICC,  Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LUIZ C.","family":"DIAS","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,5,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/1475-2875-12-187","article-title":"Designing the next generation of medicines for malaria control and eradication","volume":"12","author":"BURROWS JN","year":"2013","journal-title":"Malaria J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1021\/ed028p454","article-title":"Joseph Pelletier and Joseph Caventou","volume":"28","author":"DELEPINE M","year":"1951","journal-title":"J Chem Educ"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1128\/AAC.16.6.710","article-title":"Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique","volume":"16","author":"DESJARDINS RE","year":"1979","journal-title":"Antimicrob Agents Chemother"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0163-7258(98)00012-6","article-title":"Quinoline Antimalarials: Mechanisms of Action and Resistance and Prospects for New Agents","volume":"79","author":"FOLEY M","year":"1998","journal-title":"Pharmacol Ther"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1124\/dmd.117.077396","article-title":"An Investigation into the Prediction of in Vivo Clearance for a Range of Flavin-containing Monooxygenase Substrates","volume":"45","author":"JONES BC","year":"2017","journal-title":"Drug Metab Dispos"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/anie.200400663","article-title":"The Quest for Quinine: Those Who Won the Battles and Those Who Won the War","volume":"44","author":"KAUFMAN TS","year":"2005","journal-title":"Angew Chem Int Ed"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.ejmech.2016.12.024","article-title":"Novel Inhibitors of Plasmodium falciparum based on 2,5-disubstituted Furans","volume":"126","author":"KRAKE SH","year":"2017","journal-title":"Eur J Med Chem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"805","DOI":"10.5012\/jkcs.2011.55.5.805","article-title":"An Expeditious Room Temperature Stirring Method for the Synthesis of Isoxazolo[5,4-b]quinolines","volume":"55","author":"NIRALWAD KS","year":"2011","journal-title":"J Korean Chem Soc"},{"key":"ref9","series-title":"Anti-HIV Compounds","author":"NITZ TJ","year":"2009"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1002\/hlca.19430260622","article-title":"Synthetische Versuche in der Reihe der China-Alkaloide. (4. Mitteilung). \u00dcber Homo-merochinen und \u00fcber die partielle Synthese des Chinotoxins","volume":"26","author":"PRO\u0160TENIK M","year":"1943","journal-title":"Helv Chim Acta"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1002\/cber.190704003157","article-title":"Zur Kenntnis der Chinaalkaloide. VII. Mitteilung: \u00dcber ein neues Oxydationsprodukt des Cinchonins","volume":"40","author":"RABE P","year":"1907","journal-title":"Ber Dtsch Chem Ges"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/cber.19180510153","article-title":"\u00dcber die partielle Synthese des Chinins. Zur Kenntnis der China-Alkaloide XIX","volume":"51","author":"RABE P","year":"1918","journal-title":"Ber Dtsch Chem Ges"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1021\/jo035683q","article-title":"Synthesis and Conformational Studies of Dipeptides Constrained by Disubstituted 3-(Aminoethoxy)propionic Acid Linkers","volume":"69","author":"REDDY DS","year":"2004","journal-title":"J Org Chem"},{"key":"ref14","article-title":"P. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-action","volume":"7","author":"SANZ LM","year":"2012","journal-title":"PLoS ONE"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/anie.200601551","article-title":"The Woodward-Doering\/Rabe-Kindler Total Synthesis of Quinine: Setting the Record Straight","volume":"46","author":"SEEMAN JI","year":"2007","journal-title":"Angew Chem Int Ed"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1002\/anie.200705421","article-title":"Rabe Rest in Peace: Confirmation of the Rabe-Kindler Conversion of d-Quinotoxine Into Quinine: Experimental Affirmation of the Woodward-Doering Formal Total Synthesis of Quinine","volume":"47","author":"SMITH AC","year":"2008","journal-title":"Angew Chem Int Ed"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1021\/ja004325r","article-title":"The First Stereoselective Total Synthesis of Quinine","volume":"123","author":"STORK G","year":"2001","journal-title":"J Am Chem Soc"},{"key":"ref18","series-title":"Fact Sheet: World Malaria Report 2016","year":"2016"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1021\/ja01233a516","article-title":"The Total Synthesis of Quinine","volume":"66","author":"WOODWARD RB","year":"1944","journal-title":"J Am Chem Soc"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1021\/ja01221a051","article-title":"The Total Synthesis of Quinine","volume":"67","author":"WOODWARD RB","year":"1945","journal-title":"J Am Chem Soc"}],"container-title":["Anais da Academia Brasileira de Ci\u00eancias"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/aabc\/v90n1s2\/0001-3765-aabc-201820170820.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T20:46:59Z","timestamp":1533156419000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0001-37652018000301215&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,21]]},"references-count":20,"journal-issue":{"issue":"1 suppl 2","published-online":{"date-parts":[[2018]]}},"alternative-id":["S0001-37652018000301215"],"URL":"https:\/\/doi.org\/10.1590\/0001-3765201820170820","relation":{},"ISSN":["1678-2690","0001-3765"],"issn-type":[{"value":"1678-2690","type":"electronic"},{"value":"0001-3765","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5,21]]}}}