{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:13:03Z","timestamp":1787497983590,"version":"build-2736575974"},"reference-count":75,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Acad. Bras. Ci\u00eanc."],"DOI":"10.1590\/0001-3765202220201636","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T14:39:57Z","timestamp":1647614397000},"source":"Crossref","is-referenced-by-count":16,"title":["Algae as a source of peptides inhibitors of the angiotensin-converting enzyme: a systematic review"],"prefix":"10.1590","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7371-6278","authenticated-orcid":false,"given":"ANDREZA P. DE","family":"AMORIM","sequence":"first","affiliation":[{"name":"Universidade Federal Rural de Pernambuco\/UFRPE,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4564-3686","authenticated-orcid":false,"given":"GABRIELLY H. DA","family":"SILVA","sequence":"additional","affiliation":[{"name":"Universidade Federal Rural de Pernambuco\/UFRPE,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7045-2975","authenticated-orcid":false,"given":"ROMERO M. P.","family":"BRAND\u00c3O","sequence":"additional","affiliation":[{"name":"Universidade de Pernambuco (UPE),  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5561-5158","authenticated-orcid":false,"given":"ANA L\u00daCIA F.","family":"PORTO","sequence":"additional","affiliation":[{"name":"Universidade Federal Rural de Pernambuco\/UFRPE,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1801-2945","authenticated-orcid":false,"given":"RAQUEL P.","family":"BEZERRA","sequence":"additional","affiliation":[{"name":"Universidade Federal Rural de Pernambuco\/UFRPE,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2022]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.idairyj.2016.11.006","article-title":"Angiotensin I-converting enzyme inhibitory activity and antioxidant capacity of bioactive peptides derived from enzymatic hydrolysis of buffalo milk proteins","volume":"66","author":"ABDEL-HAMID M","year":"2017","journal-title":"Int Dairy J"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"41020","DOI":"10.1038\/s41598-019-41020-8","article-title":"Freshwater microalgae (Schizochytrium sp","volume":"9","author":"ALLEN KM","year":"2019","journal-title":"Sci Rep"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.foodchem.2019.01.010","article-title":"Identification of new bioactive peptides from Kefir milk through proteopeptidomics: Bioprospection of antihypertensive molecules","volume":"282","author":"AMORIM FG","year":"2019","journal-title":"Food Chem"},{"key":"ref4","first-page":"1228","article-title":"Biomass and lipid induction strategies in microalgae for biofuel production and other applications","volume":"18","author":"ARATBONI AH","year":"2019","journal-title":"Microb Cell Fact"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.foodchem.2017.01.143","article-title":"LC-ESI-QTOF-MS identification of novel antioxidant peptides obtained by enzymatic and microbial hydrolysis of vegetable proteins","volume":"228","author":"BABINI E","year":"2017","journal-title":"Food Chem"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.biotechadv.2006.11.002","article-title":"Micro-algae as a source of protein","volume":"25","author":"BECKER EW","year":"2007","journal-title":"Biotechnol Adv"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1161\/HYP.0b013e318293645f","article-title":"Beyond Medications and Diet: Alternative Approaches to Lowering Blood Pressure","volume":"61","author":"BROOK RD","year":"2013","journal-title":"Hypertension"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1007\/s00217-017-2886-2","article-title":"Purification and identification of a novel ACE inhibitory peptide from marine alga Gracilariopsis lemaneiformis protein hydrolysate","volume":"243","author":"CAO D","year":"2017","journal-title":"Eur Food Res Technol"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11739-016-1423-9","article-title":"Cardiovascular disease and hypertension in sub-Saharan Africa: burden, risk and interventions","volume":"11","author":"CAPPUCCIO FP","year":"2016","journal-title":"Intern Emerg Med"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1740-0929.2008.00601.x","article-title":"Determination of angiotensin-I converting enzyme inhibitory peptides in chicken leg bone protein hydrolysate with alcalase","volume":"80","author":"CHENG FY","year":"2009","journal-title":"Anim Sci J"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1039\/C8FO01146J","article-title":"Isolation, purification and the anti-hypertensive effect of a novel angiotensin I-converting enzyme (ACE) inhibitory peptide from Ruditapes philippinarum fermented with","volume":"9","author":"CHEN Y","year":"2018","journal-title":"Food Funct"},{"issue":"23","key":"ref12","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1056\/NEJMoa055202","article-title":"Major Congenital Malformations after First-Trimester Exposure to ACE Inhibitors","volume":"354","author":"COOPER WO","year":"2006","journal-title":"N Engl J Med"},{"issue":"7","key":"ref13","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/0006-2952(71)90292-9","article-title":"Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung","volume":"20","author":"CUSHMAN DW","year":"1971","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","DOI":"10.3390\/foods6050032","article-title":"Bioactive Peptides","volume":"6","author":"DALIRI E","year":"2017","journal-title":"Foods"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.foodchem.2006.09.041","article-title":"Amino acids, fatty acids, and dietary fibre in edible seaweed products","volume":"103","author":"DAWCZYNSKI C","year":"2007","journal-title":"Food Chem"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","DOI":"10.3390\/md16090299","article-title":"Antihypertensive Effects of Two Novel Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides from Gracilariopsis lemaneiformis (Rhodophyta) in Spontaneously Hypertensive Rats (SHRs)","volume":"16","author":"DENG Z","year":"2018","journal-title":"Mar Drugs"},{"key":"ref17","doi-asserted-by":"crossref","DOI":"10.1016\/j.algal.2019.101412","article-title":"Integrated techno economic and life cycle assessment of the conversion of high productivity, low lipid algae to renewable fuels","volume":"38","author":"DEROSE K","year":"2019","journal-title":"Algal Res"},{"issue":"21","key":"ref18","doi-asserted-by":"crossref","first-page":"01255","DOI":"10.1016\/S0960-9822(02)01255-1","article-title":"Just the Beginning: Novel Functions for Angiotensin-Converting Enzymes","volume":"12","author":"ERIKSSON U","year":"2002","journal-title":"Curr Biol"},{"issue":"5682","key":"ref19","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1126\/science.1095964","article-title":"The Evolution of Modern Eukaryotic Phytoplankton","volume":"305","author":"FALKOWSKI PG IPS","year":"2004","journal-title":"Science"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.etap.2016.09.023","article-title":"Potential anti-inflammatory natural products from marine algae","volume":"48","author":"FERNANDO IPS","year":"2016","journal-title":"Environ Toxicol Pharmacol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jff.2016.11.020","article-title":"Effects of milk casein hydrolyzate supplemented with phytosterols on hypertension and lipid profile in hypercholesterolemic hypertensive rats","volume":"28","author":"FERREIRA-SANTOS P","year":"2017","journal-title":"J Funct Food"},{"issue":"13","key":"ref22","doi-asserted-by":"crossref","first-page":"6829","DOI":"10.1021\/jf201114d","article-title":"Heart Health Peptides from Macroalgae and Their Potential Use in Functional Foods","volume":"59","author":"FITZGERALD C","year":"2011","journal-title":"J Agric Food Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bej.2013.10.011","article-title":"Cultivation of Chlorella vulgaris in tubular photobioreactors: A lipid source for biodiesel production","volume":"81","author":"FRUMENTO D","year":"2013","journal-title":"Biochem Eng J"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","DOI":"10.3390\/md14020032","article-title":"Angiotensin I Converting Enzyme Inhibitory Peptides Derived from Phycobiliproteins of Dulse","volume":"14","author":"FURUTA T","year":"2016","journal-title":"Mar Drugs"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1080\/10408398.2016.1224805","article-title":"A systematic review on phenolic compounds in Passiflora plants: Exploring biodiversity for food, nutrition, and popular medicine","volume":"58","author":"GADIOLI IL","year":"2018","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1021\/jf505037p","article-title":"HPLC-Q-TOF-MS Identification of Antioxidant and Antihypertensive Peptides Recovered from Cherry ( Prunus cerasus L","volume":"63","author":"GARC\u00cdA MC","year":"2015","journal-title":"J Agric Food Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.foodchem.2016.10.087","article-title":"Identification, functional gastrointestinal stability and molecular docking studies of lentil peptides with dual antioxidant and angiotensin I converting enzyme inhibitory activities","volume":"221","author":"GARC\u00cdA-MORA P","year":"2017","journal-title":"Food Chem"},{"key":"ref28","series-title":"Seaweed Proteins and Applications in Animal Feed","first-page":"139","author":"GARC\u00cdA-VAQUERO M","year":"2018"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1007\/s12010-012-0024-y","article-title":"Review on the Angiotensin-I-Converting Enzyme (ACE) Inhibitor Peptides from Marine Proteins","volume":"169","author":"HE HL","year":"2013","journal-title":"Appl Biochem Biotechnol"},{"issue":"45","key":"ref30","doi-asserted-by":"crossref","first-page":"10685","DOI":"10.1021\/jf403004e","article-title":"Measuring Angiotensin-I Converting Enzyme Inhibitory Activity by Micro Plate Assays: Comparison Using Marine Cryptides and Tentative Threshold Determinations with Captopril and Losartan","volume":"61","author":"HENDA Y","year":"2013","journal-title":"J Agric Food Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.carbon.2016.05.062","article-title":"Towards a continuous adsorption process for the enrichment of ACE-inhibiting peptides from food protein hydrolysates","volume":"107","author":"HIPPAUF F","year":"2016","journal-title":"Carbon"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s10068-017-0178-z","article-title":"Hydrolysis conditions for antioxidant peptides derived from enzymatic hydrolysates of sandfish (Arctoscopus japonicus)","volume":"26","author":"JANG HL","year":"2017","journal-title":"Food Sci Biotechnol"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.biomed.2012.06.005","article-title":"Angiotensin I-converting enzyme inhibitory peptides: Inhibition mode, bioavailability, and antihypertensive effects","volume":"2","author":"JAO CL","year":"2012","journal-title":"BioMedicine"},{"issue":"11","key":"ref34","article-title":"Screening of Angiotensin-I Converting Enzyme Inhibitory Peptides Derived from","volume":"23","author":"JOEL CH","year":"2018","journal-title":"Molecules"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1007\/s12010-016-2156-y","article-title":"Anti-inflammatory Properties of Bioactive Peptide Derived from Gastropod Influenced by Enzymatic Hydrolysis","volume":"180","author":"JOSHI I","year":"2016","journal-title":"Appl Biochem Biotechnol"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jff.2010.01.003","article-title":"Development and biological activities of marine-derived bioactive peptides: A review","volume":"2","author":"KIM SK","year":"2010","journal-title":"J Funct Food"},{"issue":"16","key":"ref37","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.2174\/1381612033454883","article-title":"Bioactive Proteins and Peptides from Food Sources","volume":"9","author":"KITTS D","year":"2003","journal-title":"Curr Pharm Des"},{"issue":"14","key":"ref38","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1055\/s-0034-1383001","article-title":"Exploring Marine Resources for Bioactive Compounds","volume":"80","author":"KIURU P","year":"2014","journal-title":"Planta Medica"},{"issue":"12","key":"ref39","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.procbio.2012.07.015","article-title":"A novel angiotensin I-converting enzyme (ACE) inhibitory peptide from a marine Chlorella ellipsoidea and its antihypertensive effect in spontaneously hypertensive rats","volume":"47","author":"KO SC","year":"2012","journal-title":"Process Biochem"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.foodchem.2009.05.080","article-title":"A HPLC-UV method for the determination of angiotensin I-converting enzyme (ACE) inhibitory activity","volume":"118","author":"LAHOGUE V","year":"2010","journal-title":"Food Chem"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.biotechadv.2011.05.017","article-title":"Health benefits of marine foods and ingredients","volume":"29","author":"LARSEN R","year":"2011","journal-title":"Biotechnol Adv"},{"key":"ref42","series-title":"Optimization of ACE inhibitory peptides from black soybean by microwave-assisted enzymatic method and study on its stability","first-page":"358\u2013365","author":"LI M","year":"2018"},{"issue":"10","key":"ref43","article-title":"Purification and Identification of Angiotensin I-Converting Enzyme Inhibitory Peptides and the Antihypertensive Effect of Chlorella sorokiniana Protein Hydrolysates","volume":"10","author":"LIN YH","year":"2018","journal-title":"Nutrients"},{"key":"ref44","article-title":"Exploration of the molecular interactions between angiotensin-I-converting enzyme (ACE) and the inhibitory peptides derived from hazelnut (Corylus heterophylla Fisch","volume":"245","author":"LIU C","year":"2018","journal-title":"Food Chem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.copbio.2018.01.017","article-title":"Exploration and exploitation of the environment for novel specialized metabolites","volume":"50","author":"LOUREIRO C","year":"2018","journal-title":"Curr Opin Biotechnol"},{"issue":"9","key":"ref46","doi-asserted-by":"crossref","DOI":"10.3390\/nu10091295","article-title":"Dose-Related Antihypertensive Properties and the Corresponding Mechanisms of a Chicken Foot Hydrolysate in Hypertensive Rats","volume":"10","author":"MAS-CAPDEVILA A","year":"2018","journal-title":"Nutrients"},{"issue":"13","key":"ref47","article-title":"NICE hypertension guideline 2011: evidence based evolution","volume":"344","author":"MCMANUS RJ","year":"2012","journal-title":"BMJ"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.foodchem.2013.11.040","article-title":"Amino acid composition of algal products and its contribution to RDI","volume":"151","author":"MI\u0160URCOV\u00c1 L","year":"2014","journal-title":"Food Chem"},{"issue":"7","key":"ref49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement","volume":"6","author":"MOHER D","year":"2009","journal-title":"PLoS Medicine"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1365-2621.2002.tb11424.x","article-title":"Antihypertensive Activities of Peptides Derived from Porcine Skeletal Muscle Myosin in Spontaneously Hypertensive Rats","volume":"67","author":"NAKASHIMA Y","year":"2002","journal-title":"J Food Sci"},{"issue":"10","key":"ref51","doi-asserted-by":"crossref","DOI":"10.3390\/md15100311","article-title":"Angiotensin I-Converting Enzyme (ACE) Inhibitory Activity, Antioxidant Properties, Phenolic Content and Amino Acid Profiles of Fucus spiralis L","volume":"15","author":"PAIVA L","year":"2017","journal-title":"Mar Drugs"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jff.2016.07.006","article-title":"Isolation and characterization of angiotensin I-converting enzyme (ACE) inhibitory peptides from Ulva rigida C","volume":"26","author":"PAIVA L","year":"2016","journal-title":"J Funct Food"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.foodchem.2016.05.087","article-title":"Purification and characterisation of a novel angiotensin-I converting enzyme (ACE)-inhibitory peptide derived from the enzymatic hydrolysate of Enteromorpha clathrata protein","volume":"211","author":"PAN S","year":"2016","journal-title":"Food Chem"},{"issue":"10","key":"ref54","doi-asserted-by":"crossref","first-page":"6440","DOI":"10.3390\/md13106440","article-title":"Assessment of the Antimicrobial Activity of Algae Extracts on Bacteria Responsible of External Otitis","volume":"13","author":"PANE G","year":"2015","journal-title":"Mar Drugs"},{"issue":"2","key":"ref55","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0014-5793(82)80156-7","article-title":"Hydrophobic interaction in thermolysin specificity","volume":"142","author":"PANK M","year":"1982","journal-title":"FEBS Letters"},{"key":"ref56","first-page":"4123","article-title":"Bioactive compounds from microalgae and cyanobacteria: utility and applications","volume":"3","author":"PRIYADARSHANI I","year":"2012","journal-title":"Intern J Pharmac Sci and Res"},{"issue":"14","key":"ref57","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24142541","article-title":"Marine Organisms as Potential Sources of Bioactive Peptides that Inhibit the Activity of Angiotensin I-Converting Enzyme: A Review","volume":"24","author":"PUJIASTUTI DY","year":"2019","journal-title":"Molecules"},{"issue":"6","key":"ref58","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00796.2011","article-title":"The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome","volume":"302","author":"PUTNAM K","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"ref59","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1007\/s11274-019-2648-3","article-title":"Algae as a green technology for heavy metals removal from various wastewater","volume":"35","author":"SALAMA ES","year":"2019","journal-title":"World J Microbiol Biotechnol"},{"issue":"5","key":"ref60","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s10811-013-9994-6","article-title":"Purification and identification of novel angiotensin-I converting enzyme (ACE) inhibitory peptides from cultured marine microalgae (Nannochloropsis oculata) protein hydrolysate","volume":"25","author":"SAMARAKOON KW","year":"2013","journal-title":"J Appl Phycol"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1017\/S0022029905001639","article-title":"Performance of two commonly used angiotensin-converting enzyme inhibition assays using FA-PGG and HHL as substrates","volume":"73","author":"SHALABY SM","year":"2006","journal-title":"J Dairy Res"},{"issue":"2","key":"ref62","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1152\/physrev.00030.2003","article-title":"Control of Aldosterone Secretion: A Model for Convergence in Cellular Signaling Pathways","volume":"84","author":"SP\u00c4T A","year":"2004","journal-title":"Physiol Rev"},{"issue":"3","key":"ref63","article-title":"Preparation and Identification of ACE Inhibitory Peptides from the Marine Macroalga Ulva intestinalis","volume":"17","author":"SUN S","year":"2019","journal-title":"Mar Drugs"},{"key":"ref64","series-title":"The Joanna Briggs Institute Reviewers\u2019 Manual 2014","year":"2014"},{"issue":"1","key":"ref65","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1111\/j.1750-3841.2011.02455.x","article-title":"Food Protein-Derived Bioactive Peptides: Production, Processing, and Potential Health Benefits","volume":"77","author":"UDENIGWE CC","year":"2012","journal-title":"J Food Sci"},{"issue":"15","key":"ref66","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1080\/10408398.2018.1452182","article-title":"Antihypertensive activity of fish protein hydrolysates and its peptides","volume":"59","author":"UG Y","year":"2019","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref67","first-page":"137","article-title":"Revalorization of a peach (Prunus persica (L","volume":"18","author":"V\u00c1SQUEZ-VILLANUEVA R","year":"2015","journal-title":"J Funct Food"},{"issue":"1","key":"ref68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/ijfe-2012-0207","article-title":"ACE-Inhibitory Peptide Isolated from Fermented Soybean Meal as Functional Food","volume":"9","author":"WANG H","year":"2013","journal-title":"Int J Food Eng"},{"issue":"19","key":"ref69","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2017.11.005","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults","volume":"71","author":"WHELTON PK","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"ref70","series-title":"A global brief on hypertension : silent killer, global public health crisis: World Health Day 2013","year":"2013"},{"key":"ref71","article-title":"Hydrolysis and purification of ACE inhibitory peptides from the marine microalga Isochrysis galbana","volume":"27","author":"WU H","year":"2014","journal-title":"J Appl Phycol"},{"issue":"3","key":"ref72","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1021\/jf051263l","article-title":"Structural Requirements of Angiotensin I-Converting Enzyme Inhibitory Peptides: Quantitative Structure\u2212Activity Relationship Study of Di- and Tripeptides","volume":"54","author":"WU J","year":"2006","journal-title":"J Agric Food Chem"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s00217-016-2792-z","article-title":"Purification and characterization of two novel angiotensin I-converting enzyme inhibitory peptides derived from R-phycoerythrin of red algae (Bangia fusco-purpurea)","volume":"243","author":"WU Q","year":"2016","journal-title":"Eur Food Res Technol"},{"issue":"6","key":"ref74","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1021\/acs.jafc.7b04294","article-title":"Antihypertensive Effects, Molecular Docking Study, and Isothermal Titration Calorimetry Assay of Angiotensin I-Converting Enzyme Inhibitory Peptides from","volume":"66","author":"XIE J","year":"2018","journal-title":"J Agric Food Chem"},{"issue":"7","key":"ref75","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1039\/C9FO00865A","article-title":"An in vivo anti-tumor effect of eckol from marine brown algae by improving the immune response","volume":"10","author":"ZHANG M","year":"2019","journal-title":"Food Funct"}],"container-title":["Anais da Academia Brasileira de Ci\u00eancias"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/aabc\/v94n2\/0001-3765-aabc-94-02-e20201636.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T14:41:05Z","timestamp":1647614465000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0001-37652022000300901&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":75,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022]]}},"alternative-id":["S0001-37652022000300901"],"URL":"https:\/\/doi.org\/10.1590\/0001-3765202220201636","relation":{},"ISSN":["1678-2690","0001-3765"],"issn-type":[{"value":"1678-2690","type":"electronic"},{"value":"0001-3765","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"e20201636"}}