{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:40:30Z","timestamp":1778712030696,"version":"3.51.4"},"reference-count":21,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>Objetivo : Avaliar o efeito da sibutramina na perda de peso de adolescentes obesos.Sujeitos e m\u00e9todos : Estudo duplo-cego placebo controlado tipo cross over com dura\u00e7\u00e3o de 13 meses. Foram inclu\u00eddos no estudo 73 adolescentes obesos de ambos os sexos com idades entre 10 e 18 anos. A avalia\u00e7\u00e3o antropom\u00e9trica foi realizada a cada 40 dias em m\u00e9dia. Os exames laboratoriais e de imagem foram realizados antes, no per\u00edodo de wash-out e ao final dos 13 meses.Resultados : A porcentagem de pacientes que perderam 10% do peso inicial no placebo foi de 46% e, no grupo sibutramina, foi de 75%. Quando usaram o placebo, o peso em m\u00e9dia se elevou em 1,61 kg, e o IMC reduziu em m\u00e9dia 0,24 kg\/m2, enquanto com o uso da sibutramina o peso reduziu em m\u00e9dia 4,47 kg e o IMC reduziu em m\u00e9dia 2,38 kg\/m2 com p &lt; 0,001.Conclus\u00f5es : A sibutramina induziu significantemente mais perda de peso em adolescentes obesos em compara\u00e7\u00e3o ao placebo, sem efeitos colaterais significativos. A curva de evolu\u00e7\u00e3o ponderal foi diferente de acordo com o momento em que a sibutramina foi introduzida. Esse achado indica que o melhor momento de introdu\u00e7\u00e3o da sibutramina \u00e9 quando a ades\u00e3o come\u00e7a a falhar. 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