{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T15:54:16Z","timestamp":1762444456312},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>After a total parathyroidectomy, well-established protocols for the cryopreservation of parathyroid tissue and for the delayed autograft of this tissue exist, especially in cases of secondary hiperparathyroidism (HPT) or familial or sporadic parathyroid hyperplasia. Although delayed autografts are effective, the published success rates vary from 10% to 83%. There are numerous factors that influence the viability, and therefore the success, of an autograft, including cryopreservation time. Certain authors believe that the tissue is only viable for 24 months, but there is no consensus on how long the parathyroid tissue can be preserved. A 63-year-old male who was diagnosed with sporadic multiple endocrine neoplasia type 1 and primary hyperparathyroidism, and was submitted to a total parathyroidectomy and an autograft in the forearm. The implant failed, and the patient developed severe hypoparathyroidism in the months following the surgery. Thirty-six months after the total parathyroidectomy, the cryopreserved autograft was successfully transplanted, and hypoparathyroidism was reversed (most recent systemic parathyroid hormone, PTH, of 36 pg\/mL, and total calcium of 9.1 mg\/dL; no oral calcium supplementation). The case presented here indicates that cryopreserved parathyroid tissue may remain viable after 24 months in storage, and may retain the capacity to reverse permanent postsurgical hypoparathyroidism. These data provide reasonable evidence that the time limit for cryopreservation remains undetermined and that additional research would be valuable. Arq Bras Endocrinol Metab. 2014;58(3):313-6<\/jats:p>","DOI":"10.1590\/0004-2730000002850","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T09:38:05Z","timestamp":1400751485000},"page":"313-316","source":"Crossref","is-referenced-by-count":3,"title":["Successful parathyroid tissue autograft after 3 years of cryopreservation: a case report"],"prefix":"10.1590","volume":"58","author":[{"given":"Ana K. N.","family":"Leite","sequence":"first","affiliation":[{"name":"Hospital das Cl\u00ednicas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clim\u00e9rio P. do N.","family":"Junior","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio S.","family":"Arap","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ledo","family":"Massoni","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delmar M.","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"HCFMUSP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lenine Garcia","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio L. de M.","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"1","key":"ref1","first-page":"49","article-title":"The transplanted parathyroid gland: evaluation of cryopreservation and other environmental factors which affect its function","volume":"75","author":"Wells SA","year":"1974","journal-title":"Surgery"},{"issue":"1","key":"ref2","first-page":"86","article-title":"The successful transplantation of frozen parathyroid tissue in man","volume":"81","author":"Wells SA","year":"1977","journal-title":"Surgery"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1007\/s00268-012-1730-x","article-title":"Cryopreservation of parathyroid tissue after parathyroid surgery for renal hyperparathyroidism: does it really make sense?","volume":"36","author":"Schneider R","year":"2012","journal-title":"World J Surg"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1067\/msy.2099.101580","article-title":"Results of heterotopic parathyroid autotransplantation: a 13-year experience","volume":"126","author":"Feldman AL","year":"1999","journal-title":"Surgery"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/S0039-6060(97)90209-9","article-title":"The current role of parathyroid cryopreservation and autotransplantation in parathyroid surgery: an institutional experience","volume":"122","author":"Caccitolo JA","year":"1997","journal-title":"Surgery"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/BF01665310","article-title":"Replantation of cryopreserved human parathyroid tissue","volume":"15","author":"Wagner PK","year":"1991","journal-title":"World J Surg"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1001\/archsurg.1992.01420070089017","article-title":"Parathyroid autotransplantation","volume":"127","author":"Herrera M","year":"1992","journal-title":"Arch Surg"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.surg.2009.10.010","article-title":"Results of cryopreserved parathyroid autografts: a retrospective multicenter study","volume":"147","author":"Borot S","year":"2010","journal-title":"Surgery"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1007\/s00268-007-9437-0","article-title":"Viability of cryopreserved parathyroid tissue: when is continued storage versus disposal indicated?","volume":"32","author":"Guerrero MA","year":"2008","journal-title":"World J Surg"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1699-0463.1999.tb01579.x","article-title":"Survival of human parathyroid tissue xenotransplanted in nude mice after 9 to 55 months? 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