{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:55:10Z","timestamp":1772254510232,"version":"3.50.1"},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>We report on a rare case of an adult with severe hypercalcemia secondary to the ectopic secretion of parathyroid-related peptide (PTH-rP) from a penile squamous cell cancer (PC). A patient of 47 years old was admitted with warty lesions and areas of ulceration covered by purulent material in a large area of the groin, scrotum and penis. Laboratory tests revealed severe hypercalcemia and elevation of PTH-rP; the biopsy reported PC. Hypercalcemia was successfully treated with zoledronic acid, however, the tumor displayed aggressive behavior, which resulted in a poor prognosis for the patient.<\/jats:p>","DOI":"10.1590\/0004-2730000002880","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T16:30:18Z","timestamp":1410193818000},"page":"646-649","source":"Crossref","is-referenced-by-count":2,"title":["Rare association between penile squamous cell carcinoma and parathyroid related peptide (PTH-rP) secretion"],"prefix":"10.1590","volume":"58","author":[{"given":"Rogelio","family":"Trejo-Rosales","sequence":"first","affiliation":[{"name":"Instituto Nacional de Ciencias Medicas y Nutricion ?Salvador Zubiran?,  Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J.","family":"Nevarez-Barragan","sequence":"additional","affiliation":[{"name":"Instituto Tecnologico y de Estudios Superiores de Monterrey,  Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes G.","family":"Rosas-Jurado","sequence":"additional","affiliation":[{"name":"Instituto Tecnologico y de Estudios Superiores de Monterrey,  Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Perez-Diaz","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Ciencias Medicas y Nutricion ?Salvador Zubiran?,  Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula Piana","family":"Bezaury","sequence":"additional","affiliation":[{"name":"UNAM,  Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"29","article-title":"Hypercalcemia of malignancy in hospitalized patients","author":"Jibrin IM","year":"2006","journal-title":"Hospital Physician"},{"key":"ref2","first-page":"1551","article-title":"Cancer-induced hypercalcemia","volume":"29","author":"Lumachi F","year":"2009","journal-title":"Anticancer Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick MF","year":"2007","journal-title":"N Engl J Med"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1053\/j.ajkd.2013.06.025","article-title":"Approach to diagnosis and treatment of hypercalcemia in a patient with malignancy","volume":"63","author":"Reagan P","year":"2013","journal-title":"Am J Kidney Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1056\/NEJM198012113032401","article-title":"Biochemical evaluation of patients with cancer-associated hypercalcemia: evidence for humoral and nonhumoral groups","volume":"303","author":"Stewart AF","year":"1980","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-5347(05)65428-6","article-title":"Parathyroid hormone related protein producing penile cancer","volume":"167","author":"Akashi T","year":"2002","journal-title":"J Urol"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1001\/jama.1965.03080170056021","article-title":"Penile malignancy and hypercalcemia","volume":"192","author":"Anderson EE","year":"1965","journal-title":"JAMA"},{"key":"ref8","first-page":"7","article-title":"Oncogu\u00eda: C\u00e1ncer de pene","volume":"6","author":"Jim\u00e9nez MA","year":"2011","journal-title":"Cancerolog\u00eda"},{"issue":"6","key":"ref9","first-page":"282","article-title":"C\u00e1ncer de pene. 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