{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T07:11:27Z","timestamp":1782371487451,"version":"3.54.5"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p> Objective: To evaluate the effect of sitagliptin on somatosensory-evoked potentials (SEPs) and metabolic control in patients with type 2 diabetes mellitus without clinical diabetic neuropathy.   Materials and methods: Interventional, prospective, and open study. Patients with less than six months from the diagnosis were included. Examinations of SEPs and laboratory tests at fasting and after food stimulation were performed before and after three months of treatment with sitagliptin (100 mg\/day).   Results: There was a reduction in the mean levels of HbA1c (P &lt; 0.0001), fasting glucose (P = 0.001), total cholesterol (P = 0.019), and ALT (P = 0.022). An increase in active GLP-1 was found at the end of the study (P = 0.0025). Several SEPs showed statistically significant differences when analyzed before and after treatment with sitagliptin.   Conclusion: The results give a glimpse of the possible use of sitagliptin in the treatment of some neurodegenerative conditions of the peripheral nervous system, in addition to its already established role in glycemic control.<\/jats:p>","DOI":"10.1590\/0004-2730000002914","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T20:46:14Z","timestamp":1493930774000},"page":"369-376","source":"Crossref","is-referenced-by-count":5,"title":["Effect of treatment with sitagliptin on somatosensory-evoked potentials and metabolic control in patients with type 2 diabetes mellitus"],"prefix":"10.1590","volume":"58","author":[{"given":"Joelma Ines Tagliapietra","family":"Barros","sequence":"first","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Vagnaldo","family":"Fechine","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renan Magalh\u00e3es","family":"Montenegro J\u00fanior","sequence":"additional","affiliation":[{"name":"UFC,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otoni Cardoso do","family":"Vale","sequence":"additional","affiliation":[{"name":"UFC,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virg\u00ednia Oliveira","family":"Fernandes","sequence":"additional","affiliation":[{"name":"UFC,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcellus Henrique Loiola Ponte de","family":"Souza","sequence":"additional","affiliation":[{"name":"UFC,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilmara Holanda da","family":"Cunha","sequence":"additional","affiliation":[{"name":"UFC,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel Odorico de","family":"Moraes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina Brasil","family":"d?Alva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elisabete Amaral de","family":"Moraes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1590\/S0004-27302012000200005","article-title":"Prescription patterns for diabetes mellitus and therapeutics implications: a population-based analysis","volume":"56","author":"Guidoni CM","year":"2012","journal-title":"Arq Bras Endocrinol Metab"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1080\/1071576031000083161","article-title":"The role of oxidative stress in diabetic vascular and neural disease","volume":"37","author":"Yorek MA","year":"2003","journal-title":"Free Radic Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.2337\/dc10-S011","article-title":"Standards of medical care in diabetes ? 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