{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T04:33:34Z","timestamp":1689395614296},"reference-count":23,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>A incid\u00eancia de polineuropatia em indiv\u00edduos com hipotireoidismo n\u00e3o \u00e9 precisamente conhecida, mas alguns estudos relatam que cerca de 25% a 42% dos pacientes podem apresentar sinais cl\u00ednicos neurop\u00e1ticos. A seguir, relataremos um caso de s\u00edndrome poliglandular autoimune tipo 2 (SPA-2), cuja apresenta\u00e7\u00e3o inicial foi uma polineuropatia hipotire\u00f3idea. Homem de 41 anos com queixas de parestesias e fraqueza lentamente progressiva acometendo os quatro membros associadas a sonol\u00eancia frequente, astenia, intoler\u00e2ncia ao frio, vertigens, n\u00e1useas e avidez por sal. O exame f\u00edsico geral evidenciava hiperpigmenta\u00e7\u00e3o de pele e mucosas, al\u00e9m de hipotens\u00e3o. O exame neurol\u00f3gico demonstrou apenas hiporreflexia profunda global e sim\u00e9trica com discretos sinais de hipoestesia superficial em extremidades dos membros. O estudo eletroneuromiogr\u00e1fico (ENMG), juntamente com a avalia\u00e7\u00e3o laboratorial, confirmou a suspeita de tireoidite de Hashimoto associada \u00e0 doen\u00e7a de Addison, caracterizando o quadro de SPA-2. O paciente foi tratado com fludrocortisona 0,05 mg\/dia e levotiroxina 100 mcg\/dia e apresentou resolu\u00e7\u00e3o gradual e completa das queixas e das altera\u00e7\u00f5es encontradas nos exames f\u00edsico geral e neurol\u00f3gico. O ENMG, repetido ap\u00f3s seis meses, evidenciou resolu\u00e7\u00e3o completa do quadro neurop\u00e1tico. Este relato mostra um caso raro de SPA-2 apresentando-se como uma polineuropatia hipotire\u00f3idea e refor\u00e7a a relev\u00e2ncia da dosagem de horm\u00f4nios tireoideanos em s\u00edndromes polineurop\u00e1ticas. A reposi\u00e7\u00e3o de levotiroxina mostrou-se efetiva em reverter o quadro cl\u00ednico e eletrofisiol\u00f3gico da neuropatia.<\/jats:p>","DOI":"10.1590\/0004-2730000003004","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T09:38:03Z","timestamp":1400751483000},"page":"308-312","source":"Crossref","is-referenced-by-count":1,"title":["Polineuropatia hipotire\u00f3idea em um paciente com s\u00edndrome poliglandular autoimune tipo 2: relato de caso"],"prefix":"10.1590","volume":"58","author":[{"given":"Alysson Guimar\u00e3es","family":"Pascoal","sequence":"first","affiliation":[{"name":"Universidade Federal de Campina Grande,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethyenne Lacerda","family":"Moreira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Campina Grande,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Guimar\u00e3es de","family":"Faria","sequence":"additional","affiliation":[{"name":"Universidade Federal de Campina Grande,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzana F. 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