{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T13:01:42Z","timestamp":1771851702230,"version":"3.50.1"},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>The term Marine-Lenhart syndrome describes the association between Graves\u2019 disease and autonomously functioning thyroid nodules (AFTN), such as toxic adenoma or toxic multinodular goiter.\u00a0The two diseases may coexist or may be present at different moments in the same patient. In the literature, there are many reports on the development of Graves\u2019 disease after radioiodine treatment for AFTN, but very little information may be found on the occurrence of AFTN after radioiodine therapy for Graves\u2019 disease. We describe here the case of a female patient with Graves\u2019 disease who was successfully treated with radioiodine for Graves\u2019 disease, returning to normal thyroid function.\u00a0Three years later, biochemical analysis and ultrasound examination identified a thyroid nodule that progressively increased in size. The 99mTc-pertechnetate scintigraphy showed avid uptake in the right lobule, which corresponded to a nodular lesion consistent with AFTN.<\/jats:p>","DOI":"10.1590\/0004-2730000003173","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T00:26:54Z","timestamp":1402964814000},"page":"398-401","source":"Crossref","is-referenced-by-count":11,"title":["An uncommon case of Marine-Lenhart syndrome"],"prefix":"10.1590","volume":"58","author":[{"given":"Giuseppe","family":"Giuffrida","sequence":"first","affiliation":[{"name":"University of Messina,  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Giovinazzo","sequence":"additional","affiliation":[{"name":"University of Messina,  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosaria","family":"Certo","sequence":"additional","affiliation":[{"name":"University of Messina,  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa Manuela","family":"Vicchio","sequence":"additional","affiliation":[{"name":"University of Messina,  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Baldari","sequence":"additional","affiliation":[{"name":"University of Messina,  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Campenn\u00ec","sequence":"additional","affiliation":[{"name":"University of Messina,  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosaria Maddalena","family":"Ruggeri","sequence":"additional","affiliation":[{"name":"University of Messina,  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1089\/thy.2011.2106.ed3","article-title":"The American Thyroid Association\/American Association of Clinical Endocrinologists guidelines for hyperthyroidism and other causes of thyrotoxicosis: an European perspective","volume":"21","author":"Kahaly GJ","year":"2011","journal-title":"Thyroid"},{"key":"ref2","first-page":"3336","article-title":"Progress in understanding the etiology of thyroid autonomy","volume":"86","author":"Krohn K","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1001\/archinte.1911.00060090002001","article-title":"Pathological anatomy of exophthalmic goiter","volume":"8","author":"Marine D","year":"1911","journal-title":"Arch Intern Med"},{"key":"ref4","first-page":"885","article-title":"Graves? 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