{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T08:25:28Z","timestamp":1776587128796,"version":"3.51.2"},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p> Objective  Thyroid volume and the prevalence of thyroid nodules are higher in patients with insulin resistance. A relationship between thyroid volume and glucose metabolism disorders (GMD) has not as yet been clarified. The present retrospective study aimed to investigate the association between GMD and thyroid volume. Subjects and methods: We investigated the data of 2,630 patients who were evaluated for thyroid biopsy in our hospital. The study population included 602 patients with GMD, 554 patients with diabetes mellitus (DM) and 1,474 patients with normal glucose metabolism as a control group. We obtained the levels of serum thyroid stimulating hormone (TSH) and the thyroid volumes of those patients retrospectively.   Results  The median ages for the control group, GMD group and DM group were 55 (15\u201091) years, 60 (27\u201097) years, and 65 (27\u201091) years respectively and there was a statistically significant difference between the groups with regard to age and gender (p&lt;0.001). Levels of TSH were similar in all groups. The median total thyroid volumes for patients with DM and GMD were significantly higher than that of the control group [22.5 (3\u2010202) mL, 20.2 (4\u2010190) mL, and 19.2 (3\u2010168) mL respectively, p\u22640.001 for all parameters]. Also the median total thyroid volume for patients with DM was significantly higher than that of the GMD group (p&lt;0.001). According to the correlation analysis, thyroid volume was significantly correlated with age (r=0.92, p&lt;0.001) and TSH (r=0.435, p&lt;0.001). Age, gender, TSH levels, GMD and DM diagnosis were independently correlated with thyroid volume.   Conclusion  The thyroid gland is one of the target tissues of metabolic disorders. We reported a positive correlation between GMD\/type 2 DM and thyroid volume. Further controlled, prospective, randomized studies on this subject are required to gain more information.<\/jats:p>","DOI":"10.1590\/0004-2730000003418","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T13:14:17Z","timestamp":1489583657000},"page":"824-827","source":"Crossref","is-referenced-by-count":16,"title":["Thyroid volume in patients with glucose metabolism disorders"],"prefix":"10.1590","volume":"58","author":[{"given":"Ayse Ocak","family":"Duran","sequence":"first","affiliation":[{"name":"Erciyes University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuneyd","family":"Anil","sequence":"additional","affiliation":[{"name":"Baskent University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alptekin","family":"Gursoy","sequence":"additional","affiliation":[{"name":"Guven Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asl\u0131","family":"Nar","sequence":"additional","affiliation":[{"name":"Baskent University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mevlude","family":"Inanc","sequence":"additional","affiliation":[{"name":"Erciyes University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oktay","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Erciyes University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neslihan Bascil","family":"Tutuncu","sequence":"additional","affiliation":[{"name":"Baskent University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ecl.2007.04.009","article-title":"Thyroid nodules: clinical importance, assessment, and treatment","volume":"36","author":"Gharib H","year":"2007","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/ejcn.2013.173","article-title":"Factors influencing thyroid volume in Chinese children","volume":"67","author":"Zou Y","year":"2013","journal-title":"Eur J Clin Nutr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1530\/EJE-09-0410","article-title":"Metabolic syndrome and its components are associated with increased thyroid volume and nodule prevalence in a mild-to-moderate iodine-deficient area","volume":"161","author":"Ayturk S","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1089\/thy.2007.0223","article-title":"Introducing the thyroid gland as another victim of the insulin resistance syndrome","volume":"18","author":"Rezzonico J","year":"2008","journal-title":"Thyroid"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.2337\/dc08-S055","article-title":"Diagnosis and classification of diabetes mellitus","volume":"31","year":"2008","journal-title":"Diabetes Care"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1080\/02841850600806308","article-title":"Thyroid ultrasound in diabetic patients without overt thyroid disease","volume":"47","author":"Junik R","year":"2006","journal-title":"Acta Radiol"},{"key":"ref7","first-page":"234","article-title":"Thyroid disorders in diabetic patients","volume":"49","author":"Pimenta WP","year":"2005","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2337\/dc10-S062","article-title":"Diagnosis and classification of diabetes mellitus","volume":"33","year":"2010","journal-title":"Diabetes Care"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.metabol.2013.01.009","article-title":"Impaired glucose metabolism is a risk factor for increased thyroid volume and nodule prevalence in a mild-to-moderate iodine deficient area","volume":"62","author":"Anil C","year":"2013","journal-title":"Metabolism"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1055\/s-2003-41806","article-title":"Thyroid volume as measured by ultrasonography in patients with type 1 diabetes mellitus without thyroid dysfunction","volume":"35","author":"G\u00f3mez JM","year":"2003","journal-title":"Horm Metab Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s00125-006-0207-6","article-title":"Fasting blood glucose and cancer risk in a cohort of more than 140,000 adults in Austria","volume":"49","author":"Rapp K","year":"2006","journal-title":"Diabetologia"},{"key":"ref12","first-page":"673","article-title":"The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies","volume":"19","author":"Rapoport B","year":"1998","journal-title":"Endocr Rev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1001\/archinte.166.17.1871","article-title":"Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan","volume":"166","author":"Inoue M","year":"2006","journal-title":"Arch Intern Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1677\/erc.1.01280","article-title":"IGF1R signalling and its inhibition","volume":"13","author":"Riedemann J","year":"2006","journal-title":"Endocr Relat Cancer"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s10654-013-9865-0","article-title":"Physical activity, diabetes, and risk of thyroid cancer: a systematic review and meta-analysis","volume":"28","author":"Schmid D","year":"2013","journal-title":"Eur J Epidemiol"}],"container-title":["Arquivos Brasileiros de Endocrinologia &amp; Metabologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abem\/v58n8\/0004-2730-abem-58-8-0824.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T18:55:35Z","timestamp":1495911335000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-27302014000800824&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0004-27302014000800824"],"URL":"https:\/\/doi.org\/10.1590\/0004-2730000003418","relation":{},"ISSN":["0004-2730"],"issn-type":[{"value":"0004-2730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11]]}}}