{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:45:11Z","timestamp":1792284311013,"version":"4.4.0"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p> Objectives: To determine the clinical presentation and treatment outcome of pediatric intracranial cavernous malformation (CM) in a single-centered institution.  Methods: Clinical data review of 30 patients under 18 years-old who had undergone surgery for cavernous malformation from January 1993 to December 2011.  Results: The Study Group included 18 males and 12 females (mean age: 8.7 years-old). Symptoms at presentation were seizures (16\/30, 53.3%), headache (15\/30, 50.0%), and focal neurological deficits (11\/30, 36.6%). Multiple cavernous malformations were found in 5\/30 (16.6%). According to location, patients were classified in groups: (G1) brain-steam in 5\/30 (16.6%), (G2) cerebellum in 2\/30 (6.6%), (G3) supratentorial associated with seizures in 16\/30 (53.3%), and (G4) supratentorial without seizures in 7\/30 (23.3%). Surgical resection was performed in 26 out of 30 (86.6%) patients. The mean follow-up period was 4.1 years. Of 15 children followed-up with preoperative seizures, all were rendered seizure-free after surgery.  Conclusions: For symptomatic solitary cavernous malformation, the treatment of choice is complete microsurgical excision preceded by careful anatomical and functional evaluation. For multiple cavernous malformation or asymptomatic patients, the treatment modalities must be cautiously considered.<\/jats:p>","DOI":"10.1590\/0004-282x20130006","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T16:41:32Z","timestamp":1368204092000},"page":"220-228","source":"Crossref","is-referenced-by-count":24,"title":["Intracranial cavernous malformation in children: a single-centered experience with 30 consecutive cases"],"prefix":"10.1590","volume":"71","author":[{"given":"Marcelo Campos Moraes","family":"Amato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Fl\u00e1vio Gurj\u00e3o","family":"Madureira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Santos de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3171\/jns.1991.75.5.0702","article-title":"An analysis of the natural history of cavernous angiomas","volume":"75","author":"Del Curling O","year":"1991","journal-title":"J Neurosurg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3171\/2011.8.PEDS09164","article-title":"Effective surgical treatment of cerebral cavernous malformations: a multicenter study of 79 pediatric patients","volume":"8","author":"Hugelshofer M","year":"2011","journal-title":"J Neurosurg Pediatr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00381-007-0465-8","article-title":"Management of intracranial cavernous malformation in pediatric patients","volume":"24","author":"Lee JW","year":"2008","journal-title":"Childs Nerv Syst"},{"key":"ref4","series-title":"Operative neurosurgical techniques: indications, methods and results","first-page":"1307","author":"Amin-Hanjani S","year":"2006"},{"key":"ref5","first-page":"1079","article-title":"Cavernous malformations: surgical management in Belo Horizonte Santa Casa Hospital","volume":"62","author":"Faria MP","year":"2004","journal-title":"Arq Neuropsiquiatr"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF00776709","article-title":"Cerebral cavernous malformations (cavernomas) in the pediatric age-group","volume":"7","author":"Mazza C","year":"1991","journal-title":"Childs Nerv Syst"},{"key":"ref7","first-page":"343","article-title":"Surgical management of paediatric cerebral cavernomas","volume":"41","author":"Di Rocco C","year":"1997","journal-title":"J Neurosurg Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/PL00014581","article-title":"Central nervous system cavernomas in the pediatric age group","volume":"24","author":"Mottolese C","year":"2001","journal-title":"Neurosurg Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000209283","article-title":"Cavernous malformations of the central nervous system in the pediatric age group","volume":"45","author":"Acciarri N","year":"2009","journal-title":"Pediatr Neurosurg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10072-009-0157-0","article-title":"Treatment and outcome of children with cerebral cavernomas: a survey on 32 patients","volume":"31","author":"Consales A","year":"2010","journal-title":"Neurol Sci"},{"key":"ref11","series-title":"Surgical treatment of the epilepsies","first-page":"609","volume-title":"Outcome with respect to epileptic seizures.","author":"Engel JJ","year":"1993"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/02688699550041467","article-title":"Results of surgery in children with cerebral cavernous angiomas causing epilepsy","volume":"9","author":"Giulioni M","year":"1995","journal-title":"Br J Neurosurg"},{"key":"ref13","first-page":"100","article-title":"The association of venous and cavernous malformations. Report of four cases and discussion of the pathophysiological, diagnostic, and therapeutic implications","volume":"92","author":"Rigamonti D","year":"1988","journal-title":"Acta Neurochir (Wien)"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000120543","article-title":"Brain stem cavernous angiomas in children","volume":"16","author":"Scott RM","year":"1990","journal-title":"Pediatr Neurosurg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3171\/jns.1994.80.3.0422","article-title":"The natural history of familial cavernous malformations: results of an ongoing study","volume":"80","author":"Zabramski JM","year":"1994","journal-title":"J Neurosurg"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000121115","article-title":"De novo familial cavernous malformation presenting with hemorrhage 12.5 years after the initial hemorrhagic Ictus: natural history of an infantile form","volume":"25","author":"Tekk\u00f6k IH","year":"1996","journal-title":"Pediatr Neurosurg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3171\/jns.1992.76.1.0038","article-title":"Cavernous angiomas of the central nervous system in children","volume":"76","author":"Scott RM","year":"1992","journal-title":"J Neurosurg"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/0090-3019(94)90262-3","article-title":"Surgical management of cavernous angiomas in children","volume":"42","author":"Giulioni M","year":"1994","journal-title":"Surg Neurol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000209284","article-title":"Pediatric cavernous malformation in the central nervous system: report of 66 cases","volume":"45","author":"Xia C","year":"2009","journal-title":"Pediatr Neurosurg"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3171\/jns.1991.75.5.0709","article-title":"Natural history of the cavernous angioma","volume":"75","author":"Robinson JR","year":"1991","journal-title":"J Neurosurg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"826","DOI":"10.3171\/jns.1980.53.6.0826","article-title":"Cerebral cavernous angiomas in children","volume":"53","author":"Pozzati E","year":"1980","journal-title":"J Neurosurg"},{"key":"ref22","first-page":"223","article-title":"Central nervous system cavernomas in children","volume":"53","author":"Lena G","year":"2007","journal-title":"Neurochirurgie"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"825","DOI":"10.3171\/jns.2001.95.5.0825","article-title":"Surgical management of brainstem cavernomas","volume":"95","author":"Samii M","year":"2001","journal-title":"J Neurosurg"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3171\/jns.1997.87.4.0629","article-title":"De novo formation of a central nervous system cavernous malformation: implications for predicting risk of hemorrhage. 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