{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:42:34Z","timestamp":1761561754333},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p> Objective: To estimate jitter parameters in myasthenia gravis in stimulated frontalis and extensor digitorum muscles using the concentric needle electrode.  Methods: Forty-two confirmed myasthenia gravis patients, being 22 males (aged 45.6\u00b117.2 years-old) were studied. Jitter was expressed as the mean consecutive difference (MCD).  Results:  MCD in extensor digitorum was 61.6 \u00b5s (abnormal in 85.7%) and in frontalis 57.3 \u00b5s (abnormal in 88.1%). Outliers represented 90.5% for extensor digitorum and 88.1% for frontalis. At least one jitter parameter was abnormal in 90.5% of the combined studies. Acetylcholine receptor antibody was abnormal in 85.7% of the cases.  Conclusions: Stimulated jitter recordings measured from muscles using concentric needle electrode can be used for myasthenia gravis diagnosis with high sensitivity. Extensive normative studies are still lacking and, therefore, borderline findings should be judged with great caution.<\/jats:p>","DOI":"10.1590\/0004-282x20130008","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T12:41:25Z","timestamp":1368189685000},"page":"237-243","source":"Crossref","is-referenced-by-count":5,"title":["Stimulated jitter with concentric needle in 42 myasthenia gravis patients"],"prefix":"10.1590","volume":"71","author":[{"given":"Jo\u00e3o Aris","family":"Kouyoumdjian","sequence":"first","affiliation":[{"name":"Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP); Neuromuscular Investigation Laboratory,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"St\u00e5lberg","sequence":"additional","affiliation":[{"name":"Uppsala University,  Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"1","article-title":"Human single muscle fiber action potentials","volume":"61","author":"Ekstedt J","year":"1964","journal-title":"Acta Neurol Scand"},{"key":"ref2","series-title":"Single fiber electromyography. Studies in healthy and diseased muscle.","first-page":"45","author":"St\u00e5lberg E","year":"1994","edition":"2nd ed"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/(SICI)1097-4598(199609)19:9<1069::AID-MUS1>3.0.CO;2-Y","article-title":"AAEM minimonograph #25: single-fiber electromyography","volume":"19","author":"Sanders DB","year":"1996","journal-title":"Muscle Nerve"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/mus.880090904","article-title":"AAEE Minimonograph #25: Single-fiber electromyography in myasthenia gravis","volume":"9","author":"Sanders DB","year":"1986","journal-title":"Muscle Nerve"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.nmd.2006.05.006","article-title":"A systematic review of diagnostic studies in myasthenia gravis","volume":"16","author":"Benatar M","year":"2006","journal-title":"Neuromuscul Disord"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/mus.21853","article-title":"Diagnostic utility of stimulated single-fiber electromyography of the Orbicularis Oculi muscle in patients with suspected ocular myasthenia","volume":"43","author":"Mercelis R","year":"2011","journal-title":"Muscle Nerve"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/mus.20568","article-title":"Concentric-needle single-fiber electromyography for the diagnosis of myasthenia gravis","volume":"34","author":"Benatar M","year":"2006","journal-title":"Muscle Nerve"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/mus.20435","article-title":"Single-fiber EMG with a concentric needle electrode: validation in myasthenia gravis","volume":"33","author":"Sarrigiannis PG","year":"2006","journal-title":"Muscle Nerve"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/(SICI)1097-4598(200005)23:5<715::AID-MUS8>3.0.CO;2-V","article-title":"Concentric needle electrode for neuromuscular jitter analysis","volume":"23","author":"Erta\u015f M","year":"2000","journal-title":"Muscle Nerve"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1590\/S0004-282X2007000300016","article-title":"Concentric needle single fiber electromyography: normative jitter values on voluntary activated Extensor Digitorum","volume":"65","author":"Kouyoumdjian JA","year":"2007","journal-title":"Arq Neuropsiquiatr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.clinph.2011.07.044","article-title":"Reference values for voluntary and stimulated single-fiber EMG using concentric needle electrodes: A multicentre prospective study","volume":"123","author":"Kokubun N","year":"2012","journal-title":"Clin Neurophysiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/j.clinph.2011.11.201","article-title":"Stimulated single fiber electromyography using a concentric needle electrode among normal filipino subjects","volume":"123","author":"Delgado-Delos Santos MMS","year":"2012","journal-title":"Clin Neurophysiol"},{"key":"ref13","first-page":"e17","article-title":"Single fiber electromyography with a concentric needle electrode and surface stimulus in the orbicularis oculi muscle","volume":"123","author":"Lozano AMR","year":"2012","journal-title":"Clin Neurophysiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/mus.21151","article-title":"Concentric and single fiber needle electrodes yield comparable jitter results in Myasthenia Gravis","volume":"39","author":"Farrugia ME","year":"2009","journal-title":"Muscle Nerve"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.clinph.2011.10.046","article-title":"A comparison between disposable and reusable single fiber needle electrodes in relation to stimulated single fiber studies","volume":"123","author":"Papathanasiou ES","year":"2012","journal-title":"Clin Neurophysiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/mus.21424","article-title":"Jitter recordings with concentric needle electrodes","volume":"40","author":"St\u00e5lberg E","year":"2009","journal-title":"Muscle Nerve"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/mus.22203","article-title":"Concentric needle jitter on stimulated frontalis and extensor digitorum in 20 myasthenia gravis patients","volume":"44","author":"Kouyoumdjian JA","year":"2011","journal-title":"Muscle Nerve"},{"key":"ref18","first-page":"218","author":"St\u00e5lberg EV","year":"2010"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1212\/WNL.55.1.16","article-title":"Myasthenia gravis. Recommendations for clinical research standards. Task force of the medical scientific advisory board of the Myasthenia Gravis Foundation of America","volume":"55","author":"Jaretzki 3rd A","year":"2000","journal-title":"Neurology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.clinph.2008.03.008","article-title":"Concentric needle single fiber electromyography: comparative jitter on voluntary-activated and stimulated Extensor Digitorum","volume":"119","author":"Kouyoumdjian JA","year":"2008","journal-title":"Clin Neurophysiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/mus.22306","article-title":"Concentric needle jitter in stimulated frontalis in 20 healthy subjects","volume":"45","author":"Kouyoumdjian JA","year":"2012","journal-title":"Muscle Nerve"},{"key":"ref22","series-title":"Clinical neurophysiology of disorders of muscle and neuromuscular junction, including fatigue","first-page":"147","author":"St\u00e5lberg E","year":"2003"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/mus.21043","article-title":"Reference jitter values for concentric needle electrodes in voluntarily activated Extensor Digitorum and Orbicularis Oculi muscles","volume":"37","author":"Kouyoumdjian JA","year":"2008","journal-title":"Muscle Nerve"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.clinph.2010.07.012","article-title":"Concentric needle jitter on stimulated Orbicularis Oculi in 50 healthy subjects","volume":"122","author":"Kouyoumdjian JA","year":"2011","journal-title":"Clin Neurophysiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/mus.20637","article-title":"A new analytical method to diagnose congenital myasthenia with stimulated single-fiber electromyography","volume":"35","author":"Tidswell T","year":"2007","journal-title":"Muscle Nerve"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v71n4\/0004-282X-anp-71-04-237.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T08:38:42Z","timestamp":1495528722000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2013000400237&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0004-282X2013000400237"],"URL":"https:\/\/doi.org\/10.1590\/0004-282x20130008","relation":{},"ISSN":["0004-282X"],"issn-type":[{"value":"0004-282X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}