{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T03:18:04Z","timestamp":1649215084132},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>Interaction of prion protein and amyloid-b oligomers has been demonstrated recently. Homozygosity at prion protein gene (PRNP) codon 129 is associated with higher risk for Creutzfeldt-Jakob disease. This polymorphism has been addressed as a possible risk factor in Alzheimer disease (AD).ObjectiveTo describe the association between codon 129 polymorphisms and AD.MethodsWe investigated the association of codon 129 polymorphism of PRNP in 99 AD patients and 111 controls, and the association between this polymorphism and cognitive performance. Other polymorphisms of PRNP and additive effect of apolipoprotein E gene (ApoE) were evaluated.ResultsCodon 129 genotype distribution in AD 45.5% methionine (MM), 42.2% methionine valine (MV), 12.1% valine (VV); and 39.6% MM, 50.5% MV, 9.9% VV among controls (p&gt;0.05). There were no differences of cognitive performance concerning codon 129. Stratification according to ApoE genotype did not reveal difference between groups.ConclusionCodon 129 polymorphism is not a risk factor for AD in Brazilian patients.<\/jats:p>","DOI":"10.1590\/0004-282x20130055","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T16:27:12Z","timestamp":1376497632000},"page":"423-427","source":"Crossref","is-referenced-by-count":5,"title":["Codon 129 polymorphism of prion protein gene in is not a risk factor for Alzheimer's disease"],"prefix":"10.1590","volume":"71","author":[{"given":"Jerusa","family":"Smid","sequence":"first","affiliation":[{"name":"USP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele Christine","family":"Landemberger","sequence":"additional","affiliation":[{"name":"A.C. Camargo Cancer Center,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria Santoro","family":"Bahia","sequence":"additional","affiliation":[{"name":"USP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilma Regina","family":"Martins","sequence":"additional","affiliation":[{"name":"A.C. Camargo Cancer Center,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Nitrini","sequence":"additional","affiliation":[{"name":"USP,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S1474-4422(03)00588-X","article-title":"Human prion diseases: epidemiology and integrated risk assessment","volume":"2","author":"Glatzel M","year":"2003","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1212\/WNL.54.5.1095","article-title":"Diagnosis of Creutzfeldt-Jakob disease: effect of clinical criteria on incidence estimates","volume":"54","author":"Brandel JP","year":"2000","journal-title":"Neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/ana.410390613","article-title":"Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease","volume":"39","author":"Parchi P","year":"1996","journal-title":"Ann Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/1471-2350-10-146","article-title":"PRNP variation in UK sporadic and variant Creutzfeldt-Jakob disease highlights genetic risk factors and a novel non-synonymous polymorphism","volume":"10","author":"Bishop MT","year":"2009","journal-title":"BMC Med Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1468-1331.2007.02021.x","article-title":"Codon 129 polymorphism of prion protein gene in sporadic Alzheimer's disease","volume":"15","author":"Poleggi A","year":"2008","journal-title":"Eur J Neurol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00702-005-0329-x","article-title":"Analysis of the polymorphic prion protein gene codon 129 in idiopathic Parkinson's disease","volume":"113","author":"Gossrau G","year":"2006","journal-title":"J Neural Transm"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.neulet.2005.10.081","article-title":"The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations","volume":"395","author":"Scholz SW","year":"2006","journal-title":"Neurosci Lett"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/ana.20646","article-title":"Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia","volume":"58","author":"Li X","year":"2005","journal-title":"Ann Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00002093-200204000-00007","article-title":"E, Caramelli P, Silveira ASB, Nitrini R. 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