{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:45:25Z","timestamp":1789728325368,"version":"4.0.1"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>Vascular mild cognitive impairment (VaMCI) represents an early symptomatic stage of vascular cognitive impairment and might be associated to fronto-executive dysfunction.MethodsTwenty-six individuals (age: 73.11\u00b17.90 years; 65.4% female; schooling: 9.84\u00b13.61 years) were selected through neuropsychological assessment and neuroimaging. Clinical and neuroimaging data of VaMCI individuals (n=15) were compared to normal controls (NC, n=11) and correlated with Fazekas scale.ResultsVaMCI performed significantly worse than NC in Trail-Making Test (TMT) B, errors in TMT B, difference TMT B-A and Cambridge Cognitive Examination (CAMCOG) final scores. Correlations were found among scores in modified Fazekas scale and performances in TMT B (time to complete and errors), difference TMT B-A and CAMCOG total score.ConclusionExtension of white matter hyperintensities might be correlated to poorer global cognition and impairments in a set of fronto-executive functions, such as cognitive speed, set shifting and inhibitory control in VaMCI.<\/jats:p>","DOI":"10.1590\/0004-282x20130057","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T16:27:16Z","timestamp":1376497636000},"page":"431-436","source":"Crossref","is-referenced-by-count":33,"title":["White matter hyperintensities, executive function and global cognitive performance in vascular mild cognitive impairment"],"prefix":"10.1590","volume":"71","author":[{"given":"Felipe Kenji","family":"Sudo","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo Oliveira","family":"Alves","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto Sousa","family":"Alves","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letice","family":"Ericeira-Valente","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Tiel","sequence":"additional","affiliation":[{"name":"UFRJ,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Madeira","family":"Moreira","sequence":"additional","affiliation":[{"name":"Hospital Pr\u00f3-Card\u00edaco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerson","family":"Laks","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil; Universidade do Estado do Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliasz","family":"Engelhardt","sequence":"additional","affiliation":[{"name":"UFRJ,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1017\/S1041610203009293","article-title":"Does vascular MCI progress at a different rate than does amnestic MCI?","volume":"15","author":"Gauthier S","year":"2003","journal-title":"Int Psychogeriatr"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild cognitive impairment as a diagnostic entity","volume":"256","author":"Petersen RC","year":"2004","journal-title":"J Intern Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S1474-4422(08)70040-1","article-title":"Vascular cognitive impairment: current concepts and clinical developments","volume":"7","author":"Moorhouse P","year":"2008","journal-title":"Lancet Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","article-title":"Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"42","author":"Gorelick PB","year":"2011","journal-title":"Stroke"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1161\/01.STR.0000024432.34557.10","article-title":"Is Mild cognitive impairment prodromal of vascular dementia like Alzheimer's disease?","volume":"33","author":"Meyer JS","year":"2002","journal-title":"Stroke"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/01.JGP.0000231780.44684.7e","article-title":"Vascular cognitive impairment","volume":"14","author":"O'Brien JT","year":"2006","journal-title":"Am J Geriatr Psychiatry"},{"key":"ref7","first-page":"S23","article-title":"Research criteria for subcortical vascular dementia in clinical trials","volume":"59","author":"Erkinjuntti T","year":"2000","journal-title":"J Neural Transm Suppl"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000091434","article-title":"Clinical determinants of dementia and mild cognitive impairment following ischemic stroke: the Sydney Stroke Study","volume":"21","author":"Sachdev PS","year":"2006","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1161\/01.STR.0000202585.26325.74","article-title":"Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study","volume":"37","author":"van Straaten EC","year":"2006","journal-title":"Stroke"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1161\/STROKEAHA.109.576629","article-title":"Diffusion-weighted imaging and cognition in the Leukoaraiosis and Disability in the Elderly Study","volume":"41","author":"Schmidt R","year":"2010","journal-title":"Stroke"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1136\/jnnp.72.2.217","article-title":"Executive dysfunction in subcortical ischaemic vascular disease","volume":"72","author":"Kramer JH","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1590\/S0004-282X2010000200005","article-title":"Impaired abstract thinking may discriminate between normal aging and vascular mild cognitive impairment","volume":"68","author":"Sudo FK","year":"2010","journal-title":"Arq Neuropsiquiatr"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1176\/jnp.14.4.377","article-title":"Executive control function: a review of its promise and challenges for clinical research. 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