{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T03:04:17Z","timestamp":1776135857178,"version":"3.50.1"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>ObjectiveThis study aimed to analyze the frequency of GSTP1-Alw26I polymorphism and to estimate its association with toxic substances in Parkinson's disease (PD).MethodsA study group with 154 patients - subdivided into familial and sporadic PD groups - and 158 elderly individuals without the disease (control group) were evaluated. GSTP1-Alw26I polymorphism was analyzed by polymerase chain reaction\/restriction fragment length polymorphism (PCR-RFLP).ResultsPatients were significantly more exposed to pesticides compared with the control group (p=0.0004), and the heterozygote genotype associated to exposure to pesticides also prevailed in patients (p=0.0001). Wild homozygote genotype was related to tobacco use (p=0.043) and alcoholism (p=0.033) in familial PD patients.ConclusionExposure to pesticides is associated to PD, whose effect can be enhanced when combined with the heterozygote genotype of GSTP1-Alw26I. Also, large genetic and environmental studies considering tobacco use, alcoholism, GSTP1 and PD are necessary to confirm our findings.<\/jats:p>","DOI":"10.1590\/0004-282x20130060","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T20:27:10Z","timestamp":1376512030000},"page":"446-452","source":"Crossref","is-referenced-by-count":15,"title":["Exposure to pesticides and heterozygote genotype of GSTP1-Alw26I are associated to Parkinson's disease"],"prefix":"10.1590","volume":"71","author":[{"given":"Gabriela S.","family":"Longo","sequence":"first","affiliation":[{"name":"S\u00e3o Jos\u00e9 do Rio Preto Medical School, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela S.","family":"Pinhel","sequence":"additional","affiliation":[{"name":"FAMERP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline L.","family":"Sado","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele L.","family":"Greg\u00f3rio","sequence":"additional","affiliation":[{"name":"FAMERP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisele S.","family":"Amorim","sequence":"additional","affiliation":[{"name":"FAMERP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greiciane S.","family":"Florim","sequence":"additional","affiliation":[{"name":"FAMERP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila M.","family":"Mazeti","sequence":"additional","affiliation":[{"name":"FAMERP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise P.","family":"Martins","sequence":"additional","affiliation":[{"name":"FAMERP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio N.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"S\u00e3o Jos\u00e9 do Rio Preto Medical School, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldir A.","family":"Tognola","sequence":"additional","affiliation":[{"name":"S\u00e3o Jos\u00e9 do Rio Preto Medical School, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo A.","family":"Nakazone","sequence":"additional","affiliation":[{"name":"Hospital de Base, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorot\u00e9ia R. 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