{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T03:26:24Z","timestamp":1772681184179,"version":"3.50.1"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>ObjectiveTo compare motor and functional performance of two groups of children with hemiplegic cerebral palsy (HCP). Only the study group (SG) received early treatment of spasticity with botulinum neurotoxin type A (BXT-A).MethodsGross Motor Function Measure (GMFM), functional performance (Pediatric Evaluation of Disability Inventory - PEDI), range of movement, gait pattern (Physician Rating Scale - PRS) and the speed of hand movements were considered.ResultsThe SG, composed of 11 HCP (45.64\u00b16.3 months), was assessed in relation to the comparison group, composed of 13 HCP (45.92\u00b16.4 months). SG showed higher scores in four of the five GMFM dimensions, which included scores that were statistically significant for dimension B, and higher scores in five of the six areas evaluated in the PEDI. Active wrist extension, the speed of hand movements and PRS score were higher in the SG.ConclusionChildren who received early BXT-A treatment for spasticity showed higher scores in motor and functional performance.<\/jats:p>","DOI":"10.1590\/0004-282x20130061","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T20:27:08Z","timestamp":1376512028000},"page":"453-461","source":"Crossref","is-referenced-by-count":8,"title":["Effects of early spasticity treatment on children with hemiplegic cerebral palsy: a preliminary study"],"prefix":"10.1590","volume":"71","author":[{"given":"Marise Bueno","family":"Zonta","sequence":"first","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isac","family":"Bruck","sequence":"additional","affiliation":[{"name":"UFPR,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilene","family":"Puppi","sequence":"additional","affiliation":[{"name":"UFPR,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Muzzolon","sequence":"additional","affiliation":[{"name":"UFPR,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnolfo de Carvalho","family":"Neto","sequence":"additional","affiliation":[{"name":"UFPR,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facia Helena Coutinho dos","family":"Santos","sequence":"additional","affiliation":[{"name":"UFPR,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1046\/j.1468-1331.2001.00046.x","article-title":"Management of the upper limb with botulinum toxin type A in children with spastic type cerebral palsy and acquired brain injury: clinical implications","volume":"8","author":"Autti-R\u00e4m\u00f6 I","year":"2001","journal-title":"Eur J Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1097\/GRF.0b013e31818a0431","article-title":"Neurodevelopmental management strategies for children with cerebral palsy: optimizing function, promoting participation, and supporting families","volume":"51","author":"Msall ME","year":"2008","journal-title":"Clin Obstet Gynecol"},{"key":"ref3","series-title":"International Classification of Functioning, Disability and Health","year":"2001"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1542\/peds.2007-0016","article-title":"Botulinum toxin for spasticity in children with cerebral palsy: a comprehensive evaluation","volume":"120","author":"Bjornson K","year":"2007","journal-title":"Pediatrics"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00702-008-0175-8","article-title":"Effectiveness of botulinum toxin A for upper and lower limb spasticity in children with cerebral palsy: a summary of evidence","volume":"116","author":"Lukban MB","year":"2009","journal-title":"J Neural Transm"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.pediatrneurol.2010.12.001","article-title":"Effective results with botulinum toxin in cerebral palsy","volume":"44","author":"Coutinho dos Santos LH","year":"2011","journal-title":"Pediatr Neurol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1046\/j.1468-1331.2001.00038.x","article-title":"The effect of botulinum toxin type A on the functional ability of the child with spastic hemiplegia: a randomized controlled trial","volume":"8","author":"Love SC","year":"2001","journal-title":"Eur J Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0966-6362(99)00054-5","article-title":"Recommendations for the use of botulinum toxin type A in the management of cerebral palsy","volume":"11","author":"Graham HK","year":"2000","journal-title":"Gait Posture"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1469-8749.1997.tb07414.x","article-title":"Development and reliability of a system to classify gross motor function in children with cerebral palsy","volume":"39","author":"Palisano R","year":"1997","journal-title":"Dev Med Child Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/088307380101600107","article-title":"Clinical utility of botulinum toxin in the treatment of cerebral palsy: comprehensive review","volume":"16","author":"Edgar TS","year":"2001","journal-title":"J Child Neurol"},{"key":"ref11","first-page":"540","article-title":"Preliminary trial of carisoprodol in multiple sclerosis","volume":"192","author":"Ashworth B","year":"1964","journal-title":"Practitioner"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1542\/peds.108.5.1062","article-title":"Botulinum toxin type A neuromuscular blockade in the treatment of equinus foot deformity in cerebral palsy: a multicenter, open-label clinical trial","volume":"108","author":"Koman LA","year":"2001","journal-title":"Pediatrics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1469-8749.1989.tb04003.x","article-title":"The gross motor function measure: a mean to evaluate the effects of physical therapy","volume":"31","author":"Russell DJ","year":"1989","journal-title":"Dev Med Child Neurol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/j.1469-8749.2007.00751.x","article-title":"The natural history of gross motor development in children with cerebral palsy aged 1 to 15 years","volume":"49","author":"Beckung E","year":"2007","journal-title":"Dev Med Child Neurol"},{"key":"ref15","article-title":"Wechsler Preschool and Primary Scale of Intelligence - Revised David Wechsler","author":"Wechsler D","year":"1989","journal-title":"The Psychological Corporation Harrourt Brace Jovanovich"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00589107","article-title":"Morphology of cerebral lesions in children with congenital hemiplegia. A study with computed tomography","volume":"32","author":"Wicklund LM","year":"1990","journal-title":"Neuroradiology"},{"key":"ref17","series-title":"Pediatric evaluation of disability inventory: development, standardization and administration manual","author":"Haley SM","year":"1991"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.pediatrneurol.2004.05.002","article-title":"Pediatric physical functioning reference curves","volume":"31","author":"Haley SM","year":"2004","journal-title":"Pediatr Neurol"},{"key":"ref19","series-title":"Efeitos do tratamento da espasticidade com toxina botul\u00ednica do tipo A na fun\u00e7\u00e3o motora grossa de lactentes com Paralisia Cerebral forma Hemipl\u00e9gica [Thesis]","author":"Zonta MB","year":"2009"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1136\/bmj.326.7396.970","article-title":"Cerebral palsy: what parents and doctors want to know","volume":"326","author":"Rosenbaum P","year":"2003","journal-title":"BMJ"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"S150","DOI":"10.1046\/j.1468-1331.2001.00048.x","article-title":"Management of upper limb dysfunction in children with cerebral palsy: a systematic review","volume":"8","author":"Boyd RN","year":"2001","journal-title":"Eur J Neurol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1590\/s1679-45082010ao1678","article-title":"Two-dimensional analysis of gait asymmetry in spastic hemiplegia","volume":"8","author":"Zonta MB","year":"2010","journal-title":"Einstein"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1469-8749.2005.tb01213.x","article-title":"Functional therapy for children with cerebral palsy: an ecological approach","volume":"47","author":"Ahl LE","year":"2005","journal-title":"Dev Med Child Neurol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ejpn.2008.10.006","article-title":"Safety of botulinum toxin type A in children younger than 2 years","volume":"13","author":"Pascual-Pascual SI","year":"2009","journal-title":"Eur J Neurol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/01241398-200007000-00021","article-title":"A Preliminary report of the use of botulinum toxin type A in infants with clubfoot: four case studies","volume":"20","author":"Delgado MR","year":"2000","journal-title":"J Pediatr Orthop"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ejpn.2008.07.008","article-title":"Long-term use of botulinum toxin type A in children with cerebral palsy: treatment consistency","volume":"13","author":"Molenaers G","year":"2009","journal-title":"Eur J Paediatr Neurol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1017\/S0012162200000426","article-title":"Comparison of the Gross Motor Function Measure and Paediatric Evaluation of Disability Inventory in assessing motor function in children undergoing selective dorsal rhizotomy","volume":"42","author":"Nordmark E","year":"2000","journal-title":"Dev Med Child Neurol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1590\/S0004-282X2002000300020","article-title":"Compara\u00e7\u00e3o do desempenho de atividades funcionais em crian\u00e7as com desenvolvimento normal e crian\u00e7as com paralisia cerebral","volume":"60","author":"Mancini MC","year":"2002","journal-title":"Arq Neuropsiquiatr"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1469-8749.1975.tb04952.x","article-title":"Locomotor prognosis in cerebral palsy","volume":"17","author":"Bleck EE","year":"1975","journal-title":"Dev Med Child Neurol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1542\/peds.2007-0068","article-title":"Probability of walking in children with cerebral palsy in Europe","volume":"121","author":"Beckung E","year":"2008","journal-title":"Pediatrics"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v71n7\/0004-282X-anp-71-07-453.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T06:41:15Z","timestamp":1495521675000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2013000700453&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0004-282X2013000700453"],"URL":"https:\/\/doi.org\/10.1590\/0004-282x20130061","relation":{},"ISSN":["0004-282X"],"issn-type":[{"value":"0004-282X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}