{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:00:37Z","timestamp":1778839237078,"version":"3.51.4"},"reference-count":10,"publisher":"FapUNIFESP (SciELO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>Thymoma screening is recommended at the onset of myasthenia gravis (MG) or when patients with MG present with clinical deterioration or a progressive increase of anti-acetylcholine receptor antibody. However, it is unknown if it is necessary to repeat the screening of thymoma at fixed intervals, even in the absence of MG deterioration, when the initial screening is negative. We analyzed the recurrence rate and incidence of new thymoma in a series of patients with well-controlled MG. The sample consisted of 53 patients, aged 17 to 72 years, and the follow-up varied between 75 and 472 months. The chest computerized tomography detected thymus abnormalities in eight patients at the initial screening and no abnormalities in all patients at a second screening after five years. The findings of this study support the classical opinion that screening for thymoma should be recommended only if there is clinical deterioration due to the disease.<\/jats:p>","DOI":"10.1590\/0004-282x20130062","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T20:27:10Z","timestamp":1376512030000},"page":"462-464","source":"Crossref","is-referenced-by-count":4,"title":["Myasthenia gravis and thymus: long-term follow-up screening of thymectomized and non-thymectomized patients"],"prefix":"10.1590","volume":"71","author":[{"given":"Paulo Jos\u00e9","family":"Lorenzoni","sequence":"first","affiliation":[{"name":"UFPR,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Pires","family":"Augusto","sequence":"additional","affiliation":[{"name":"UFPR,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia Suemi Kamoi","family":"Kay","sequence":"additional","affiliation":[{"name":"UFPR,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosana Herminia","family":"Scola","sequence":"additional","affiliation":[{"name":"UFPR,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lineu Cesar","family":"Werneck","sequence":"additional","affiliation":[{"name":"UFPR,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.thorsurg.2010.08.009","article-title":"Management of myasthenic patients with thymoma","volume":"21","author":"Zielinski M","year":"2011","journal-title":"Thorac Surg Clin"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1212\/01.WNL.0000032502.89361.0C","article-title":"Thymoma in patients with MG: characteristics and long-term outcome","volume":"59","author":"Evoli A","year":"2002","journal-title":"Neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jneuroim.2009.12.010","article-title":"Long-term follow up of thymus in patients with myasthenia gravis","volume":"221","author":"Sugawara M","year":"2010","journal-title":"J Neuroimmunol"},{"key":"ref4","first-page":"327","article-title":"Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America","volume":"70","author":"Jaretzki 3rd A","year":"2000","journal-title":"Ann Thorac Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1212\/WNL.0b013e3181dc1b1e","article-title":"The MG Composite: a valid and reliable outcome measure for myasthenia gravis","volume":"74","author":"Burns TM","year":"2010","journal-title":"Neurology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.athoracsur.2004.06.090","article-title":"Thymoma and myasthenia gravis: a clinical study of 1,089 patients from Japan","volume":"79","author":"Kondon K","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.athoracsur.2009.08.074","article-title":"Thirty-five-year follow-up analysis of clinical and pathologic outcomes of thymoma surgery","volume":"89","author":"Margaritora S","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"ref8","first-page":"894","article-title":"Single-centre 40-year results of redo operation for recurrent thymomas","volume":"40","author":"Margaritora S","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0936-6555(05)80783-6","article-title":"Dramatic response of recurrent invasive thymoma to high doses of corticosteroids","volume":"4","author":"Kirkove C","year":"1992","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"ref10","first-page":"740583","article-title":"Three types of striational antibodies in myasthenia gravis","author":"Suzuki S","year":"2011","journal-title":"Autoimmune Dis 2011"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v71n7\/0004-282X-anp-71-07-462.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T06:04:36Z","timestamp":1495519476000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2013000700462&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0004-282X2013000700462"],"URL":"https:\/\/doi.org\/10.1590\/0004-282x20130062","relation":{},"ISSN":["0004-282X"],"issn-type":[{"value":"0004-282X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}