{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:06:20Z","timestamp":1792285580404,"version":"4.4.0"},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"9A","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p> Objective To compare neuromotor development between patients who did and those who did not undergo intrauterine myelomeningocele repair.   Methods Children with myelomeningocele aged between 3.5 and 6 years who did undergo intrauterine repair (Group A, n=6) or not (Group B; n=7) were assessed for neuromotor development at both anatomical and functional levels, need for orthoses, and cognitive function.   Results Intrauterine myelomeningocele repair significantly improved motor function. The functional level was higher than the anatomical level by 2 or more spinal segments in all children in Group A and 2 children in Group B, with a significant statistical difference between groups (p&lt;0.05). Five children in Group A and one in Group B were community ambulators.   Conclusion Despite the small sample, it was observed that an improvement of motor function and decreased need for postnatal shunting in the 6 children who had undergone intrauterine myelomeningocele repair.<\/jats:p>","DOI":"10.1590\/0004-282x20130104","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T17:11:55Z","timestamp":1383066715000},"page":"604-608","source":"Crossref","is-referenced-by-count":17,"title":["Improvement of motor function and decreased need for postnatal shunting in children who had undergone intrauterine myelomeningocele repair"],"prefix":"10.1590","volume":"71","author":[{"given":"Tereza Cristina Carbonari de","family":"Faria","sequence":"first","affiliation":[{"name":"Universidade Federal de Sao Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Cavalheiro","sequence":"additional","affiliation":[{"name":"UNIFESP,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner Jou","family":"Hisaba","sequence":"additional","affiliation":[{"name":"UNIFESP,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Fernandes","family":"Moron","sequence":"additional","affiliation":[{"name":"UNIFESP,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Regina","family":"Torloni","sequence":"additional","affiliation":[{"name":"UNIFESP,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Lucia Batista de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Peixoto","family":"Borges","sequence":"additional","affiliation":[{"name":"UNIFESP,  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Columbia","author":"Burgemeister BB","year":"1977"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2106\/00004623-197355010-00014","article-title":"Functional ambulation in patients with myelomeningocele","volume":"55","author":"Hoffer MM","year":"1973","journal-title":"J Bone Joint Surg Am"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1469-8749.1991.tb14913.x","article-title":"Ambulatory outcome of children with myelomeningocele: effect of lower-extremity muscle strength","volume":"33","author":"McDonald CM","year":"1991","journal-title":"Dev Med Child Neurol"},{"key":"ref19","series-title":"Resultado perinatal e tardio em crian\u00e7as submetidas \u00e0 corre\u00e7\u00e3o intra-uterina da mielomeningocele [Thesis]","author":"Hisaba WJ","year":"2008"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.ajog.2005.02.071","article-title":"Impact of maternal-fetal surgery for myelomeningocele on 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