{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T15:58:36Z","timestamp":1760975916246},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>Myocardial scintigraphy with meta-iodo-benzyl-guanidine (123I cMIBG) has been studied in Parkinson's disease (PD), especially in Asian countries, but not in Latin America. Most of these studies include individuals with PD associated to a defined dysautonomia. Our goal is to report the cardiac sympathetic neurotransmission in de novo Brazilian patients with sporadic PD, without clinically defined dysautonomia. We evaluated retrospectively a series of 21 consecutive cases with PD without symptoms or signs of dysautonomia assessed by the standard bedside tests. This number was reduced to 14 with the application of exclusion criteria. 123I cMIBG SPECT up-take was low or absent in all of them and the heart\/mediastinum ratio was low in 12 of 14. We concluded that 123I cMIBG has been able to identify cardiac sympathetic neurotransmission disorder in Brazilian de novo PD patients without clinically defined dysautonomia.<\/jats:p>","DOI":"10.1590\/0004-282x20140042","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T20:00:43Z","timestamp":1403726443000},"page":"430-434","source":"Crossref","is-referenced-by-count":7,"title":["Cardiac 123I-MIBG uptake in de novo Brazilian patients with Parkinson's disease without clinically defined dysautonomia"],"prefix":"10.1590","volume":"72","author":[{"given":"Marco Antonio Araujo","family":"Leite","sequence":"first","affiliation":[{"name":"Universidade Federal Fluminense, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo J. M.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Santos","family":"Pereira","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clayton","family":"Amaral","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udio T.","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brazil; Hospital Pr\u00f3-Card\u00edaco, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jader C.","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brazil; Hospital Pr\u00f3-Card\u00edaco, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana S. X. de","family":"Brito","sequence":"additional","affiliation":[{"name":"Hospital Barra D?Or, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe Villela","family":"Pedras","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Medicina Nuclear Villela Pedras, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Principles and practice of Movement disorders","volume-title":"Clinical overview and phenomenology of movement disorders","author":"Fahn S","year":"2011","edition":"Second edition"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases","volume":"55","author":"Hughes AJ","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1590\/0004-282X20130005","article-title":"Frequency of non-motor symptoms in Peruvian patients with Parkinson's disease","volume":"71","author":"Cosentino C","year":"2013","journal-title":"Arq Neuropsiquiatr"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1590\/0004-282X20130001","article-title":"Non-motor symptoms in Parkinson's disease. 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