{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T02:52:42Z","timestamp":1721875962927},"reference-count":62,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>Central nervous system (CNS) restoration is an important clinical challenge and stem cell transplantation has been considered a promising therapeutic option for many neurological diseases. Objective : The present review aims to briefly describe stem cell biology, as well as to outline the clinical application of stem cells in the treatment of diseases of the CNS. Method : Literature review of animal and human clinical experimental trials, using the following key words: \u201cstem cell\u201d, \u201cneurogenesis\u201d, \u201cParkinson\u201d, \u201cHuntington\u201d, \u201camyotrophic lateral sclerosis\u201d, \u201ctraumatic brain injury\u201d, \u201cspinal cord injury\u201d, \u201cischemic stroke\u201d, and \u201cdemyelinating diseases\u201d. Conclusion : Major recent advances in stem cell research have brought us several steps closer to their effective clinical application, which aims to develop efficient ways of regenerating the damaged CNS.<\/jats:p>","DOI":"10.1590\/0004-282x20140045","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T20:01:06Z","timestamp":1403726466000},"page":"457-465","source":"Crossref","is-referenced-by-count":18,"title":["Stem cells in neurology - current perspectives"],"prefix":"10.1590","volume":"72","author":[{"given":"Chary Ely Marquez","family":"Batista","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric Domingos","family":"Mariano","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suely Kazue 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