{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:16:53Z","timestamp":1790648213633,"version":"4.1.0"},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>The effects of tamoxifen (TAM) on anxiety and depression-like behavior in ovariectomized (OVX) and na\u00efve female rats were investigated. The animals were divided into Sham-TAM, OVX-TAM, Sham and OVX groups. Tamoxifen (1 mg\/kg) was administered for 4 weeks. In the forced swimming test, the immobility times in the OVX and Sham-TAM groups were higher than in the Sham group. In the open field, the numbers of central crossings in the OVX and Sham-TAM groups were lower than the number in the Sham group, and the number of peripheral crossings in the OVX group was lower than the number in the Sham group. In the elevated plus maze, the numbers of entries to the open arm among the animals in the Sham-TAM and OVX groups were lower than the number in the Sham group, while the number of entries to the open arm in the OVX-TAM group was higher than the number in the OVX group. It was shown that deletion of ovarian hormones induced anxiety and depression-like behavior. Administration of tamoxifen in na\u00efve rats led to anxiety and depression-like behavior that was comparable with the effects of ovarian hormone deletion. It can be suggested that tamoxifen antagonizes the effects of ovarian hormones. It also seems that tamoxifen has anxiolytic effects on ovariectomized rats.<\/jats:p>","DOI":"10.1590\/0004-282x20140221","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T15:52:19Z","timestamp":1424879539000},"page":"132-139","source":"Crossref","is-referenced-by-count":30,"title":["Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats"],"prefix":"10.1590","volume":"73","author":[{"given":"Hamid","family":"Azizi-Malekabadi","sequence":"first","affiliation":[{"name":"Islamic Azad University,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoume","family":"Pourganji","sequence":"additional","affiliation":[{"name":"Mashhad University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Zabihi","sequence":"additional","affiliation":[{"name":"Mashhad University of Medical Sciences,  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USA"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0006-8993(87)80034-3","article-title":"Upregulation of imipramine binding and serotonin uptake by estradiol in female rat brain","volume":"410","author":"Rehavi M","year":"1987","journal-title":"Brain Res"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1111\/j.1471-4159.1977.tb12313.x","article-title":"Effect of oestradiol on turnover of type A monoamine oxidase in brain","volume":"28","author":"Luine VN","year":"1977","journal-title":"J Neurochem"},{"issue":"1-2","key":"ref17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0006-8993(97)00418-6","article-title":"Estrogen as a neuromodulator of MPTP-induced neurotoxicity: effects upon striatal dopamine release","volume":"764","author":"Disshon KA","year":"1997","journal-title":"Brain 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