{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T09:43:40Z","timestamp":1743673420452},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>Objective : Convulsive status epilepticus (CSE) is very rarely observed after ischaemic stroke. Sodium valproate (SV) is one of the agents used in the treatment of CSE, but its role still controversial, and its degree of efficacy in treating CSE that develops following stroke is unclear. Method : We evaluated 19 patients who were treated with intravenous (IV) SV (20 mg\/kg, 2 mg\/kg\/h-12h) after diazepam. Patients\u2019 modified Rankin scores (mRS), SE types, and changes in biochemical parameters after treatment were assessed. Results : CSE was successfully treated in 12 (63.15%) patients. Side effects such as hypotension and allergic reactions were observed in two patients. Refractory SE development was observed in 5 (29.4%) patients with high mRS (\u02c3 3). No significant deterioration in patients\u2019 laboratory evaluations, conducted before and after status, was observed. Conclusion : SV may be safe and effective in the treatment of CSE observed after ischaemic stroke, especially in patients with low mRS.<\/jats:p>","DOI":"10.1590\/0004-282x20150001","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T19:01:22Z","timestamp":1489604482000},"page":"293-297","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the efficacy of sodium valproate in convulsive status epilepticus following to \u0131schemic stroke"],"prefix":"10.1590","volume":"73","author":[{"given":"Hasan H\u00fcseyin","family":"\u00d6zdemir","sequence":"first","affiliation":[{"name":"Dicle University Neurology, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00fclent","family":"M\u00fcngen","sequence":"additional","affiliation":[{"name":"F\u0131rat University Neurology, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sel\u00e7uk","family":"\u0130lhan","sequence":"additional","affiliation":[{"name":"F\u0131rat University Pharmacology Department, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1212\/WNL.46.4.1029","article-title":"A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia","volume":"46","author":"DeLorenzo RJ","year":"1996","journal-title":"Neurology"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1212\/WNL.43.3_Part_1.483","article-title":"Status epilepticus at an urban public hospital in the 1980s","volume":"43","author":"Lowenstein DH","year":"1993","journal-title":"Neurology"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1468-1331.2006.01253.x","article-title":"Computed tomographic changes of the brain and clinical outcome of patients with seizures and epilepsy after an ischaemic hemispheric stroke","volume":"13","author":"De Reuck j","year":"2006","journal-title":"Eur J Neurol."},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1212\/WNL.54.2.350","article-title":"Status epilepticus in stroke: report on a hospital-based stroke cohort","volume":"54","author":"Rumbach L","year":"2000","journal-title":"Neurology"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2009.08.007","article-title":"Ischaemic stroke in adults and epilepsy","volume":"87","author":"Menon B","year":"2009","journal-title":"Epilepsy Res"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000227289","article-title":"Status epilepticus in stroke patients","volume":"62","author":"De Reuck J","year":"2009","journal-title":"Eur Neurol"},{"issue":"4","key":"ref7","first-page":"271","article-title":"Management of stroke-related seizures","volume":"109","author":"De Reuck J","year":"2009","journal-title":"Acta Neurol Belg"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s12028-007-0056-2","article-title":"Convulsive status epilepticus after ischemic stroke and intracerebral hemorrhage: frequency, predictors, and impact on outcome in a large administrative dataset","volume":"7","author":"Bateman BT","year":"2007","journal-title":"Neurocrit Care"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1212\/01.wnl.0000224880.35053.26","article-title":"Sodium valproate vs phenytoin in status epilepticus: a pilot study","volume":"67","author":"Misra UK","year":"2006","journal-title":"Neurology"},{"issue":"13","key":"ref10","article-title":"The efficacy of intravenous sodium valproate and phenytoin as the first-line treatment in status epilepticus: a comparison study","volume":"27","author":"Tiamkao S","year":"2013","journal-title":"BMC Neurol"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1161\/01.STR.22.10.1242","article-title":"Assessment of scales of disability and handicap for stroke patients","volume":"22","author":"Wolfe CD","year":"1991","journal-title":"Stroke"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1528-1157.1981.tb06159.x","article-title":"Proposal for revised clinical and electro-encephalographic classification of epileptic seizures","volume":"22","year":"1981","journal-title":"Epilepsia"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/hs1201.100209","article-title":"Epidemiology of ischemic stroke subtypes according to TOAST criteria","volume":"32","author":"Kolominsky-Rabas PL","year":"2001","journal-title":"Stroke"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1161\/01.STR.32.5.1169","article-title":"Status epilepticus after stroke","volume":"32","author":"Velio\u011flu SK","year":"2001","journal-title":"Stroke"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1001\/archneur.57.11.1617","article-title":"Seizures after stroke: a prospective multicenter study","volume":"57","author":"Bladin CF","year":"2000","journal-title":"Arch Neurol"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1001\/archneur.1990.00530020053014","article-title":"Epileptic seizures in acute stroke","volume":"47","author":"Kilpatrick CJ","year":"1990","journal-title":"Arch Neurol"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1212\/WNL.43.5.895","article-title":"Prognostic factors of pentobarbital therapy for refractory generalized status epilepticus","volume":"43","author":"Yaffe K","year":"1993","journal-title":"Neurology"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/jnnp.2004.041947","article-title":"Predictors and prognosis of refractory status epilepticus treated in a neurological intensive care unit","volume":"76","author":"Holtkamp M","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"15","key":"ref19","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.clinbiochem.2013.06.012","article-title":"Adverse drug reactions induced by valproic acid","volume":"46","author":"Nanau RM","year":"2013","journal-title":"Clin Biochem"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.7812\/TPP\/10-140","article-title":"Acute hypersensitivity syndrome caused by valproic Acid: a review of the literature and a case report","volume":"15","author":"Bota RG","year":"2011","journal-title":"Perm J"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.amjopharm.2010.04.005","article-title":"Probable valproate sodium-associated hypotension","volume":"8","author":"Ota KS","year":"2010","journal-title":"Am J Geriatr Pharmacother"},{"issue":"70","key":"ref22","first-page":"37","article-title":"Drugs for epilepsy","volume":"6","year":"2008","journal-title":"Treat Guidel Med Lett"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v73n4\/0004-282X-anp-73-4-0293.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T10:42:44Z","timestamp":1658832164000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2015000400293&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S0004-282X2015000400293"],"URL":"https:\/\/doi.org\/10.1590\/0004-282x20150001","relation":{},"ISSN":["0004-282X"],"issn-type":[{"value":"0004-282X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}