{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:57:03Z","timestamp":1792000623975,"version":"4.4.0"},"reference-count":10,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>The year of 2014 is the birth centenary of Aristides Azevedo Pacheco Le\u00e3o (1914-1993), and also marks seventy years of the publication of his discovery of the novel electrophysiological phenomenon, named by him \u201cspreading depression\u201d (SD), soon designated \u201cLe\u00e3o\u2019s wave\u201d or \u201cLe\u00e3o\u2019s spreading depression\u201d. This was a remarkable scientific milestone, and the author must be celebrated for this achievement, as the studies he triggered proceeded worldwide, with new concepts, as spreading depolarization, until the present days. Robust experimental and clinical evidence emerged to suggest that these and related electrophysiological phenomena are involved in the mechanisms of migraine aura, acute cerebrovascular diseases, traumatic brain injury, transient global amnesia, epileptic seizures, and their pathophysiological characteristics come to offer new therapeutic perspectives. He was a remarkable and complex personality, and the authors remit the readers to a paper where his personal life is contemplated.<\/jats:p>","DOI":"10.1590\/0004-282x20150045","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T23:05:45Z","timestamp":1433977545000},"page":"544-546","source":"Crossref","is-referenced-by-count":5,"title":["Aristides Le\u00e3o: a birth centennial homage with comments on his spreading depression"],"prefix":"10.1590","volume":"73","author":[{"given":"Eliasz","family":"Engelhardt","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleide da Mota","family":"Gomes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1526-4610.2008.01210.x","article-title":"Professor Aristides Le\u00e3o. Much more than spreading depression","volume":"49","author":"Maranh\u00e3o Filho P","year":"2009","journal-title":"Headache"},{"key":"ref2","series-title":"Construtores do Instituto de Biof\u00edsica Carlos Chagas Filho","first-page":"31","volume-title":"Aristides de Azevedo Pacheco Le\u00e3o","author":"Gattass R","year":"2013"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1212\/01.wnl.0000183281.12779.cd","article-title":"Leao\u2019s cortical spreading depression: from experimental \u201cartifact\u201d to physiological principle","volume":"65","author":"Teive HA","year":"2005","journal-title":"Neurology"},{"key":"ref4","series-title":"Um aprendiz de ci\u00eancia","first-page":"93","volume-title":"Cap\u00edtulo 5: Instituto de Biof\u00edsica Carlos Chagas Filho","author":"Chagas Filho C","year":"2000"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/jn.1944.7.6.359","article-title":"Spreading depression of activity in the cerebral cortex","volume":"7","author":"Le\u00e3o AAP","year":"1944","journal-title":"J Neurophysiol"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1152\/jn.1944.7.6.391","article-title":"Pial circulation and spreading depression of activity in the cerebral cortex","volume":"7","author":"Le\u00e3o AAP","year":"1944","journal-title":"J Neurophysiol"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1152\/jn.1945.8.1.33","article-title":"Propagation of spreading cortical depression","volume":"8","author":"Leao AAP","year":"1945","journal-title":"J Neurophysiol"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1152\/jn.1947.10.6.409","article-title":"Further observations on the spreading depression of activity in the cerebral cortex","volume":"10","author":"Le\u00e3o AAP","year":"1947","journal-title":"J Neurophysiol"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nm.2333","article-title":"The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease","volume":"17","author":"Dreier JP","year":"2011","journal-title":"Nat Med"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/jcbfm.2010.191","article-title":"Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury","volume":"31","author":"Lauritzen M","year":"2011","journal-title":"J Cereb Blood Flow Metabol"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v73n6\/0004-282X-anp-73-6-0544.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T14:41:04Z","timestamp":1566830464000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2015000600544&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0004-282X2015000600544"],"URL":"https:\/\/doi.org\/10.1590\/0004-282x20150045","relation":{},"ISSN":["0004-282X"],"issn-type":[{"value":"0004-282X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6]]}}}