{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:10:09Z","timestamp":1769155809277,"version":"3.49.0"},"reference-count":16,"publisher":"FapUNIFESP (SciELO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>Objective The purpose of this study was to describe the endoscopic combined \u201ctransseptal\/transnasal\u201d approach with a pedicled nasoseptal flap for pituitary adenoma and skull base reconstruction, especially with respect to cerebrospinal fluid (CSF) fistula.Method Ninety-one consecutive patients with pituitary adenomas were retrospectively reviewed. All patients underwent the endoscopic combined \u201ctransseptal\/transnasal\u201d approach by the single team including the otorhinolaryngologists and neurosurgeons. Postoperative complications related to the flap were analyzed.Results Intra- and postoperative CSF fistulae were observed in 36 (40%) and 4 (4.4%) patients, respectively. Among the 4 patients, lumbar drainage and bed rest healed the CSF fistula in 3 patients and reoperation for revision was necessary in one patient. Other flap-related complications included nasal bleeding in 3 patients (3.3%).Conclusion The endoscopic combined \u201ctransseptal\/transnasal\u201d approach is most suitable for a two-surgeon technique and a pedicled nasoseptal flap is a reliable technique for preventing postoperative CSF fistula in pituitary surgery.<\/jats:p>","DOI":"10.1590\/0004-282x20150070","type":"journal-article","created":{"date-parts":[[2015,7,19]],"date-time":"2015-07-19T02:39:18Z","timestamp":1437273558000},"page":"611-615","source":"Crossref","is-referenced-by-count":11,"title":["Endoscopic combined \u201ctransseptal\/transnasal\u201d approach for pituitary adenoma: reconstruction of skull base using pedicled nasoseptal flap in 91 consecutive cases"],"prefix":"10.1590","volume":"73","author":[{"given":"Yasunori","family":"Fujimoto","sequence":"first","affiliation":[{"name":"Osaka Neurological Institute,  Japan; Complexo Hospitalar Edmundo Vasconcelos,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Balsalobre","sequence":"additional","affiliation":[{"name":"Complexo Hospitalar Edmundo Vasconcelos,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio P.","family":"Santos","sequence":"additional","affiliation":[{"name":"Complexo Hospitalar Edmundo Vasconcelos,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Vellutini","sequence":"additional","affiliation":[{"name":"DFV Neuro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo C.","family":"Stamm","sequence":"additional","affiliation":[{"name":"Complexo Hospitalar Edmundo Vasconcelos,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00006123-199702000-00001","article-title":"Complications of transsphenoidal 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