{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T21:36:34Z","timestamp":1692308194561},"reference-count":16,"publisher":"FapUNIFESP (SciELO)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Nitric oxide (NO) is a major neurotransmitter associated with motor control in basal ganglia. Movement disorders, as essential tremor and Parkinson\u2019s disease, are more prevalent on aged individuals. We investigated the effects of aging on neuronal density and diameter\/area of nitrergic neurons in samples of striatum (caudate and putamen) and subthalamic nucleus of 20 human brains from normal subjects, stained by histochemistry for NADPH-diaphorase and immunohistochemistry for neuronal NO synthase. Our data showed aging does not modify the neuronal density and size of nitrergic neurons in striatum and subthalamic nucleus. These findings suggest a lack of association between aging and morphologic changes on nitrergic neurons.<\/jats:p>","DOI":"10.1590\/0004-282x20150097","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T19:10:32Z","timestamp":1441221032000},"page":"779-783","source":"Crossref","is-referenced-by-count":1,"title":["Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus"],"prefix":"10.1590","volume":"73","author":[{"given":"Bruno Lopes dos","family":"Santos-Lobato","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine Aparecida","family":"Del-Bel","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Eymard Homem","family":"Pittella","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitor","family":"Tumas","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009621","article-title":"Functional neuroanatomy of the basal ganglia","volume":"2","author":"Lanciego JL","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"6197","key":"ref2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/336385a0","article-title":"Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain","volume":"336","author":"Garthwaite J","year":"1988","journal-title":"Nature"},{"issue":"16","key":"ref3","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1212\/WNL.0b013e318233b3e4","article-title":"Nitric oxide: a pleiotropic signal in the nervous system","volume":"77","author":"Benarroch EE","year":"2011","journal-title":"Neurology"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2174\/138161211795164176","article-title":"Role of nitric oxide in motor control: implications for Parkinson\u2019s disease pathophysiology and treatment","volume":"17","author":"Del-Bel E","year":"2011","journal-title":"Curr Pharm Des"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/cne.20616","article-title":"Morphological features, distribution and compartmental organization of the nicotinamide adenine dinucleotide phosphate reduced-diaphorase interneurons in the human striatum","volume":"489","author":"Bern\u00e1cer J","year":"2005","journal-title":"J Comp Neurol"},{"issue":"1-4","key":"ref6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0169-328X(94)90062-0","article-title":"Nitric oxide synthase mRNA expression in human subthalamic nucleus, striatum and globus pallidus: implications for basal ganglia function","volume":"22","author":"Nisbet AP","year":"1994","journal-title":"Brain Res Mol Brain Res"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0304-3940(93)90673-9","article-title":"A correlation between soluble brain nitric oxide synthase and NADPH-diaphorase activity is only seen after exposure of the tissue to fixative","volume":"155","author":"Matsumoto T","year":"1993","journal-title":"Neurosci Lett"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0306-4522(92)90184-4","article-title":"Histochemical mapping of nitric oxide synthase in the rat brain","volume":"46","author":"Vincent SR","year":"1992","journal-title":"Neuroscience"},{"key":"ref9","series-title":"Atlas of the human brain","author":"Mai K","year":"2004"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0165-0173(94)00007-C","article-title":"Functional anatomy of the basal ganglia. 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