{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:04:40Z","timestamp":1780491880241,"version":"3.54.1"},"reference-count":58,"publisher":"FapUNIFESP (SciELO)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"abstract":"<jats:p>Trigeminal neuralgia (TN) patients may develop side effects from centrally acting drugs, have contraindications for neurosurgical procedures, or experience relapse during conventional therapies. OnabotulinumtoxinA (BoNT\/A) has been reported to be effective for TN, although this finding has been challenged. An overview of the available evidence based on a narrative\/qualitative analysis of the literature is presented. About 90% of patients who receive BoNT\/A show an improvement, a higher figure than that reported for the placebo effect of BoNT\/A for other headaches. Tolerability of BoNT\/A is good, and its few side-effects are transient. The articles reviewed were mainly case reports, case series and open-label trials; however, randomized controlled trials have endorsed the efficacy of BoNT\/A for TN. This evidence, together with a better understanding of the analgesic mechanisms of BoNT\/A and its proven efficacy in treating other pain syndromes, supports the use of this toxin as a therapeutic option for TN.<\/jats:p>","DOI":"10.1590\/0004-282x20150109","type":"journal-article","created":{"date-parts":[[2015,8,8]],"date-time":"2015-08-08T21:54:25Z","timestamp":1439070865000},"page":"877-884","source":"Crossref","is-referenced-by-count":17,"title":["OnabotulinumtoxinA for trigeminal neuralgia: a review of the available data"],"prefix":"10.1590","volume":"73","author":[{"given":"Pedro A.","family":"Kowacs","sequence":"first","affiliation":[{"name":"Instituto de Neurologia de Curitiba,  Brazil; Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A. 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