{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T21:52:20Z","timestamp":1648936340606},"reference-count":10,"publisher":"FapUNIFESP (SciELO)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>ABSTRACTThe authors present a Brazilian case series of eight patients with idiopathic very-late onset (mean 75.5 years old) cerebellar ataxia, featuring predominantly gait ataxia, associated with cerebellar atrophy.Method: 26 adult patients with a diagnosis of idiopathic late onset cerebellar ataxia were analyzed in a Brazilian ataxia outpatient clinic and followed regularly over 20 years. Among them, 8 elderly patients were diagnosed as probable very late onset cerebellar ataxia. These patients were evaluated with neurological, ophthalmologic and Mini-Mental Status examinations, brain MRI, and EMG.Results: 62.5% of patients were males, mean age was 81.9 years-old, and mean age of onset was 75.5 years. Gait cerebellar ataxia was observed in all patients, as well as, cerebellar atrophy on brain MRI. Mild cognitive impairment and visual loss, due to macular degeneration, were observed in 50% of cases. Chorea was concomitantly found in 3 patients.Conclusion: We believe that this condition is similar the one described by Marie-Foix-Alajouanine presenting with mild dysarthria, associated with gait ataxia, and some patients had cognitive dysfunction and chorea.<\/jats:p>","DOI":"10.1590\/0004-282x20150139","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T21:22:34Z","timestamp":1445721754000},"page":"903-905","source":"Crossref","is-referenced-by-count":1,"title":["Idiopathic very late-onset cerebellar ataxia: a Brazilian case series"],"prefix":"10.1590","volume":"73","author":[{"given":"H\u00e9lio A. G.","family":"Teive","sequence":"first","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Moscovich","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Moro","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Farah","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter O.","family":"Arruda","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato P.","family":"Munhoz","sequence":"additional","affiliation":[{"name":"University of Toronto,  Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S1474-4422(09)70305-9","article-title":"Sporadic ataxia with adult onset: classification and diagnostic criteria","volume":"9","author":"Klockgether T","year":"2010","journal-title":"Lancet Neurol"},{"issue":"1-2","key":"ref2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jns.2005.06.006","article-title":"Late-onset cerebellar ataxia: differentiating those with and without identifiable mutations","volume":"238","author":"Kerber KA","year":"2005","journal-title":"J Neurol Sci"},{"key":"ref3","series-title":"The hereditary ataxias and related disorders","author":"Harding AE","year":"1984"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0022-510X(81)90104-0","article-title":"\u201cIdiopathic\u201d late onset cerebellar ataxia: a clinical and genetic study of 36 cases","volume":"51","author":"Harding AE","year":"1981","journal-title":"J Neurol Sci"},{"key":"ref5","first-page":"849","article-title":"De l\u2019atrophie c\u00e9r\u00e9belleuse tardive \u00e0 pr\u00e9dominance corticale","volume":"2","author":"Marie P","year":"1922","journal-title":"Revue Neurol (Paris)"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s004390000346","article-title":"Genetic background of apparently idiopathic sporadic cerebellar ataxia","volume":"107","author":"Sch\u00f6ls L","year":"2000","journal-title":"Hum Genet"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/brain\/awf107","article-title":"The aetiology of sporadic adult-onset ataxia","volume":"125","author":"Abele M","year":"2002","journal-title":"Brain"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/mds.25847","article-title":"Multiple system atrophy of the cerebellar type: clinical state of the art","volume":"29","author":"Lin DJ","year":"2014","journal-title":"Mov Disord"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1212\/WNL.55.4.527","article-title":"Evolution of sporadic olivopontocerebellar atrophy into multiple system atrophy","volume":"55","author":"Gilman S","year":"2000","journal-title":"Neurology"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1002\/mds.10606","article-title":"Pure cerebello-olivary degeneration of Marie, Foix, and Alajouanine presenting with progressive cerebellar ataxia, cognitive decline, and chorea","volume":"18","author":"Fox SH","year":"2003","journal-title":"Mov Disord"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v73n11\/0004-282X-anp-73-11-0903.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T07:52:58Z","timestamp":1495525978000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2015001100903&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0004-282X2015001100903"],"URL":"https:\/\/doi.org\/10.1590\/0004-282x20150139","relation":{},"ISSN":["0004-282X"],"issn-type":[{"value":"0004-282X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11]]}}}