{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T03:41:46Z","timestamp":1653363706580},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1590\/0004-282x2015016","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T21:22:23Z","timestamp":1445721743000},"page":"897-898","source":"Crossref","is-referenced-by-count":0,"title":["Challenges to understand the mitochondrial respiratory diseases caused by mitochondrial DNA mutations"],"prefix":"10.1590","volume":"73","author":[{"given":"Suely Kazue Nagahashi","family":"Marie","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3109\/07853890.2011.598547","article-title":"Mechanisms of mitochondrial diseases","volume":"44","author":"Ylikallio E","year":"2012","journal-title":"Ann Med"},{"issue":"6158","key":"ref2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/331717a0","article-title":"Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies","volume":"331","author":"Holt IJ","year":"1988","journal-title":"Nature"},{"issue":"4884","key":"ref3","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.3201231","article-title":"Mitochondrial DNA mutation associated with Leber\u2019s hereditary optic neuropathy","volume":"242","author":"Wallace DC","year":"1988","journal-title":"Science"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ajhg.2008.07.004","article-title":"Pathogenic mitochondrial DNA mutations are common in the general population","volume":"83","author":"Elliott HR","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"6302","key":"ref5","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/348651a0","article-title":"A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies","volume":"348","author":"Goto Y","year":"1990","journal-title":"Nature"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.mito.2006.12.004","article-title":"Population prevalence of the MELAS A3243G mutation","volume":"7","author":"Manwaring N","year":"2007","journal-title":"Mitochondrion"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/ng0892-368","article-title":"Mutation in mitochondrial tRNA(Leu)(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness","volume":"1","author":"Ouweland JM","year":"1992","journal-title":"Nat Genet"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/ana.410160409","article-title":"Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: A distinctive clinical syndrome","volume":"16","author":"Pavlakis SG","year":"1984","journal-title":"Ann Neurol"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.braindev.2004.01.002","article-title":"Clinical features of A3243G mitochondrial tRNA mutation","volume":"26","author":"Chae JH","year":"2004","journal-title":"Brain Dev"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1590\/0004-282X20150154","article-title":"When should MELAS (Mitochondrial myopathy, encephalopathy, lactic acidosis, amd stroke-like episodes)be the diagnosis?","volume":"73","author":"Lorenzoni PJ","year":"2015","journal-title":"Arq Neuropsiquiatr"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.bbadis.2008.02.001","article-title":"The impact of mitochondrial tRNA mutations on the amount of ATP synthase differs in the brain compared to other tissues","volume":"1782","author":"Fornuskova D","year":"2008","journal-title":"Biochim Biophys Acta"},{"issue":"38","key":"ref12","doi-asserted-by":"crossref","first-page":"E3622","DOI":"10.1073\/pnas.1311660110","article-title":"Tissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model","volume":"110","author":"H\u00e4m\u00e4l\u00e4inen RH","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/B978-0-12-801415-8.00019-9","article-title":"Induced pluripotent stem cell-derived models for mtDNA diseases","volume":"547","author":"H\u00e4m\u00e4l\u00e4inen RH","year":"2014","journal-title":"Methods Enzymol"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1002\/stem.683","article-title":"Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming","volume":"29","author":"Prigione A","year":"2011","journal-title":"Stem Cells"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.fob.2015.03.008","article-title":"Impaired respiratory function in MELAS-induced pluripotent stem cells with high heteroplasmy levels","volume":"5","author":"Kodaira M","year":"2015","journal-title":"FEBS Open Bio"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v73n11\/0004-282X-anp-73-11-0897.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T03:12:35Z","timestamp":1653361955000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2015001100897&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0004-282X2015001100897"],"URL":"https:\/\/doi.org\/10.1590\/0004-282x2015016","relation":{},"ISSN":["0004-282X"],"issn-type":[{"value":"0004-282X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11]]}}}