{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:13:00Z","timestamp":1779887580761,"version":"3.53.1"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>ABSTRACT Purpose of the study was evaluate the possible antinociceptive effect of botulinum neurotoxin type-A (BoNT\/A) in an experimental model of trigeminal neuralgia. Method Neuropathic pain was induced by surgical constriction of the infraorbital nerve in rats. A control group underwent a sham procedure consisting of surgical exposure of the nerve. Subgroups of each group received either BoNT\/A or isotonic saline solution. The clinical response was assessed with the -20\u00b0C test. Animals that underwent nerve constriction developed sensitization; the sham group did not. Results The sensitization was reversed by BoNT\/A treatment evident 24 hours following application. Pronociceptive effect was observed in the sham group following BoNT\/A. Conclusion BoNT\/A has an antinociceptive effect in sensitized animals and a pronociceptive effect in non-sensitized animals.<\/jats:p>","DOI":"10.1590\/0004-282x20160067","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T17:47:16Z","timestamp":1466012836000},"page":"462-469","source":"Crossref","is-referenced-by-count":4,"title":["Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect"],"prefix":"10.1590","volume":"74","author":[{"given":"Elcio J","family":"Piovesan","sequence":"first","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Brasil; Universidade Federal do Paran\u00e1, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Oshinsky","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Silberstein","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Andre","family":"Kowacs","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edison Matos","family":"Novak","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lineu Cesar","family":"Werneck","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1177\/0333102413485658","article-title":"The International Classification of Headache 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