{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:43:17Z","timestamp":1762875797572},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>ABSTRACT The purpose of this case series is to report eight patients with giant prolactinomas emphasizing presentations and a treatment complication. The study group included six men and two women. The median age was 29 years (18\u201354 years); median serum prolactin level was 4,562 ng\/ml (1,543\u201318,690 ng\/ml); three patients (37.5%) had panhypopituitarism; median tumor diameter was 50 mm (41\u201360 mm). Five patients (62.5%) had visual field defects and three had improvement during treatment; six patients (75%) reached prolactin normalization, with a median time of 10.5 months (7\u201384 months) and median dose of 2.0 mg\/week (1.0 to 3.0 mg\/week). One patient presented as a true incidentaloma. One patient presented a cerebrospinal fluid leakage during medical treatment and refused surgery, however this resolved with conservative measures. This case series illustrate a rare subtype of macroprolactinomas, the importance of considering unusual presentations at the diagnosis, the effectiveness of pharmacological treatment and its possible complications.<\/jats:p>","DOI":"10.1590\/0004-282x20160083","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T12:30:41Z","timestamp":1469622641000},"page":"544-548","source":"Crossref","is-referenced-by-count":3,"title":["Prolactinomas may have unusual presentations resulting from massive extrasellar tumor extension"],"prefix":"10.1590","volume":"74","author":[{"given":"Marise Ribeiro de Sousa","family":"Berriel","sequence":"first","affiliation":[{"name":"Universidade Federal Fluminense, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna Aparecida Balarini","family":"Lima","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro Severo Alves de","family":"Melo","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Laura Vasconcelos dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Rahhal","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle Fernandes","family":"Taboada","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"4","key":"ref1","first-page":"996","article-title":"Management of prolactinomas","volume":"82","author":"Molitch 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