{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:00:24Z","timestamp":1780408824882,"version":"3.54.1"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>ABSTRACT Objective Neurofibromatosis type 1 (NF1) causes neural and cutaneous disorders and reduced exercise capacity. Exercise\/heat exposure increasing internal temperature must be compensated by eccrine sweat function and warmed skin vasodilation. We suspected NF1 could adversely affect eccrine sweat function and\/or vascular thermoregulatory responses (VTR). Methods The eccrine sweat function and VTR of 25 NF1 volunteers (14 males, 11 females; 16\u201357 years old) were compared with 23 non-NF1 controls matched by sex, age, height and weight (CG). Sweating was induced by 1) pilocarpine 1% iontophoresis (PILO); and 2) by passive heating (HEAT) via the lower third of the legs being immersed in 42\u00b0C water for one hour. Previously established eccrine sweat function and VTR protocols were used. Results The NF1 group showed: a) lower sweat rate than the CG group during PILO; b) a smaller diastolic pressure decrease; and c) higher tympanic temperatures than controls during HEAT (p &lt; 0.05). Conclusion Reduced sweating and vascular thermoregulatory responses suggest autonomic dysfunction in NF1 individuals.<\/jats:p>","DOI":"10.1590\/0004-282x20160122","type":"journal-article","created":{"date-parts":[[2016,10,15]],"date-time":"2016-10-15T21:36:29Z","timestamp":1476567389000},"page":"796-802","source":"Crossref","is-referenced-by-count":5,"title":["Autonomic thermoregulatory dysfunction in neurofibromatosis type 1"],"prefix":"10.1590","volume":"74","author":[{"given":"Luciana G","family":"Madeira","sequence":"first","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata LF","family":"Passos","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana F de","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilton A","family":"Rezende","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz O. C.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brasil; Universidade Federal de Minas Gerais, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/jmg.2006.045906","article-title":"Guidelines for the diagnosis and management of individuals with neurofibromatosis 1","volume":"44","author":"Ferner RE","year":"2007","journal-title":"J Med Genet"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/bdra.20616","article-title":"Neurofibromatosis type 1 is a disorder of dysplasia: the importance of distinguishing features, consequences, and complications","volume":"88","author":"Riccardi VM","year":"2010","journal-title":"Birth Defects Res A Clin Mol 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