{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:17:21Z","timestamp":1787023041553,"version":"build-2736575974"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>ABSTRACT Objective To perform the translation, cultural adaptation and validation of the Myasthenia Gravis Composite (MGC) scale in Brazil. Methods The study was conducted at three neuromuscular disease research centers in accordance with the international ethical standards, following a multi-modal approach and was conducted in three steps consisting of translation, cultural adaptation, and validation according to international guidelines. The final version of the MGC was applied in a sample of 27 MG patients and the total score was compared to a Portuguese version of the MG-QOL-15. Results The internal consistency verified by Cohen\u2019s Kappa test was excellent (0.766). The correlation between the MGC and MG-QOL-15 was strong (R = 0.777; p = 0.000). No significant differences were found between the responses of patients in the first and second applications of the MGC. Conclusion The MGC scale, validated into Brazilian Portuguese, has proven to be a reliable instrument that is easy to use, and is highly reproducible.<\/jats:p>","DOI":"10.1590\/0004-282x20160129","type":"journal-article","created":{"date-parts":[[2016,11,26]],"date-time":"2016-11-26T16:19:32Z","timestamp":1480177172000},"page":"914-920","source":"Crossref","is-referenced-by-count":8,"title":["Brazilian-Portuguese translation, cross-cultural adaptation and validation of the Myasthenia Gravis Composite scale. A multicentric study"],"prefix":"10.1590","volume":"74","author":[{"given":"Ezequiel Fernandes","family":"Oliveira","sequence":"first","affiliation":[{"name":"Universidade Nove de Julho, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria Cavalcante","family":"Lima","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Araujo","family":"Perez","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Nunes","family":"Polaro","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice Cataldo Oliveira","family":"Val\u00e9rio","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o R","family":"Pereiro","sequence":"additional","affiliation":[{"name":"Hospital do Servidor P\u00fablico Estadual, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Roberto","family":"Nacif","sequence":"additional","affiliation":[{"name":"Hospital do Servidor P\u00fablico Estadual, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Santos","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Nove de Julho, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Acary Souza Bulle","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Vicente Franco","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Nove de Julho, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"issue":"25","key":"ref1","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1056\/NEJM199406233302507","article-title":"Myasthenia gravis","volume":"330","author":"Drachman DB","year":"1994","journal-title":"N Engl J Med"},{"issue":"4088","key":"ref2","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1126\/science.180.4088.871","article-title":"Autoimmune response to acetylcholine receptor","volume":"180","author":"Patrick J","year":"1973","journal-title":"Science"},{"issue":"1","key":"ref3","article-title":"A systematic review of population based epidemiological studies in Myasthenia Gravis","volume":"10","author":"Carr AS","year":"2010","journal-title":"BMC Neurology"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1468-1331.2010.03017.x","article-title":"Course and prognosis of myasthenia gravis: a systematic review","volume":"17","author":"Mao ZF","year":"2010","journal-title":"Eur J Neurol"},{"issue":"1","key":"ref5","first-page":"327","article-title":"Myasthenia gravis: recommendations for clinical research standards","volume":"70","author":"Jaretzki 3rd A","year":"2000","journal-title":"Ann Thorac Surg"},{"issue":"5","key":"ref6","first-page":"29","article-title":"Measuring quality of life today: methodological aspects","volume":"4","author":"Cella DF","year":"1990","journal-title":"Oncology (Willinston Park)"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1056\/NEJM198703193161205","article-title":"Preliminary results of a double-blind, randomized, placebo-controlled trial of cyclosporine in myasthenia gravis","volume":"316","author":"Tindall RS","year":"1987","journal-title":"N Engl J Med"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1749-6632.1993.tb22937.x","article-title":"A clinical therapeutic trial of cyclosporine in myasthenia gravis","volume":"681","author":"Tindall RS","year":"1993","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"ref9","first-page":"139","article-title":"Outcome research and patient-oriented measures in the multiperspective assessment of neurological and musculoskeletal disorders. Consensus Conference: Third Roman Neurophysiology Day, Outcome Research in Neurology and in Musculoskeletal Disorders \u2013 24 October 1998","volume":"20","author":"Tonali P","year":"1999","journal-title":"Ital J Neurol Sci"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10072-009-0167-y","article-title":"Concordance between severity of disease, disability and health-related quality of life in myasthenia gravis","volume":"31","author":"Raggi A","year":"2010","journal-title":"Neurol Sci"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s00415-009-5279-z","article-title":"The relationship between health, disability and quality of life in myasthenia gravis: results from an Italian study","volume":"257","author":"Leonardi M","year":"2010","journal-title":"J Neurol"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1023\/A:1008893007068","article-title":"The use of quality of life data in clinical practice","volume":"7","author":"Morris J","year":"1998","journal-title":"Qual Life Res"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s100720200027","article-title":"Myasthenia gravis outcome measure: development and validation of a disease-specific self-administered questionnaire","volume":"23","author":"Padua L","year":"2002","journal-title":"Neurol Sci"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.52.7.1487","article-title":"Myasthenia gravis activities of daily living profile","volume":"52","author":"Wolfe GI","year":"1999","journal-title":"Neurology"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1749-6632.2012.06817.x","article-title":"The myasthenia gravis: specific activities of daily living profile","volume":"1274","author":"Muppidi S","year":"2012","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/mus.21609","article-title":"Construct and concurrent validation of the MG-QOL15 in the practice setting","volume":"41","author":"Burns TM","year":"2010","journal-title":"Muscle Nerve"},{"issue":"10","key":"ref17","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1212\/WNL.33.10.1316","article-title":"Myasthenia gravis: long-term correlation of binding and bungarotoxin blocking antibodies against acetylcholine receptors with changes in disease severity","volume":"33","author":"Besinger UA","year":"1983","journal-title":"Neurology"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/mus.21185","article-title":"Construction of an efficient evaluative instrument for myasthenia gravis: the MG composite","volume":"38","author":"Burns TM","year":"2008","journal-title":"Muscle Nerve"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1590\/0004-282X20130180","article-title":"Brazilian cross-cultural translation and adaptation of the \u201cQuestionnaire of Life Quality Specific for Myasthenia Gravis - 15 items\u201d","volume":"71","author":"Mour\u00e3o AM","year":"2013","journal-title":"Arq. 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