{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T16:46:13Z","timestamp":1774629973254,"version":"3.50.1"},"reference-count":12,"publisher":"FapUNIFESP (SciELO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"abstract":"<jats:p>ABSTRACT The circle of Willis is an important collateral system that maintains perfusion to the stenotic area from the contralateral carotid and basilar artery to the region of reduced brain perfusion. The aim of the present study was to compare the circle of Willis anomaly in patients with unilateral symptomatic and asymptomatic carotid artery disease.  Results  In this retrospective study, we analyzed 175 patients who presented at our outpatient stroke clinic between January, 2013 and June, 2015 with either unilateral symptomatic or asymptomatic carotid artery disease, and who had had CT angiography imaging performed. Demographic properties, carotid artery stenosis and the anomaly of the circle of Willis was recorded.  Conclusion  There was no statistically significant difference in patients with symptomatic and asymptomatic carotid artery disease in terms of the anomaly of the circle of Willis.<\/jats:p>","DOI":"10.1590\/0004-282x20170054","type":"journal-article","created":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T14:18:34Z","timestamp":1500473914000},"page":"429-432","source":"Crossref","is-referenced-by-count":6,"title":["The association of the circle of Willis anomaly and risk of stroke in patients with carotid artery disease"],"prefix":"10.1590","volume":"75","author":[{"given":"Eylem \u00d6zayd\u0131n","family":"G\u00f6ksu","sequence":"first","affiliation":[{"name":"Antalya Education and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u0131nar","family":"Ko\u00e7","sequence":"additional","affiliation":[{"name":"Antalya Education and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"K\u00fc\u00e7\u00fckseymen","sequence":"additional","affiliation":[{"name":"Antalya Education and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"\u00dcnal","sequence":"additional","affiliation":[{"name":"Akdeniz University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Gen\u00e7","sequence":"additional","affiliation":[{"name":"Antalya Education and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif Sar\u0131\u00f6nder","family":"Gencer","sequence":"additional","affiliation":[{"name":"Antalya Education and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aylin","family":"Yaman","sequence":"additional","affiliation":[{"name":"Antalya Education and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2017,7]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1161\/STROKEAHA.112.663716","article-title":"Cerebrovascular reserve and stroke risk in patients with carotid stenosis or occlusion: a systematic review and meta-analysis","volume":"43","author":"Gupta A","year":"2012","journal-title":"Stroke"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2174\/157340309789317887","article-title":"Cerebral collateral circulation in carotid artery disease","volume":"5","author":"Romero JR","year":"2009","journal-title":"Curr Cardiol Rev"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000098326","article-title":"Anatomic variations in the circle of Willis in patients with symptomatic carotid artery stenosis assessed with multidetector row CT angiography","volume":"23","author":"Waaijer A","year":"2007","journal-title":"Cerebrovasc Dis"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1161\/01.STR.31.1.128","article-title":"Angiographically defined collateral circulation and risk of stroke in patients with severe carotid artery stenosis","volume":"31","author":"Henderson RD","year":"2000","journal-title":"Stroke"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/01.STR.22.6.816","article-title":"investigators. 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