{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:55:37Z","timestamp":1780419337365,"version":"3.54.1"},"reference-count":10,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>ABSTRACT We studied multiple sclerosis (MS) patients with the HLA-DQB1*06:02 allele and compared them with MS patients who did not carry the HLA-DQB1*06:02 allele. We analyzed clinical and neurophysiological criteria for narcolepsy in six MS patients with HLA-DQB1*06:02, compared with 12 MS patients who were HLA-DQB1*06:02 non-carriers. Only two patients with HLA-DQB1*06:02 allele scored higher than 10 on the Epworth Sleepiness Scale. Polysomnography recording parameters and the multiple sleep latency test showed an absence of narcolepsy in the study group. Our study suggested no significant correlation between narcolepsy, MS and HLA-DQB1*06:02. The HLA-DQB1*06:02 allele alone was not sufficient to cause MS patients to develop narcolepsy.<\/jats:p>","DOI":"10.1590\/0004-282x20170063","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T17:55:36Z","timestamp":1498240536000},"page":"345-348","source":"Crossref","is-referenced-by-count":5,"title":["Is there a relationship between narcolepsy, multiple sclerosis and HLA-DQB1*06:02?"],"prefix":"10.1590","volume":"75","author":[{"given":"Paulo Jos\u00e9","family":"Lorenzoni","sequence":"first","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lineu Cesar","family":"Werneck","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Christina de Souza","family":"Crippa","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Zanatta","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia S. Kamoi","family":"Kay","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo S.","family":"Silvado","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana Herminia","family":"Scola","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"issue":"3","key":"ref1","first-page":"294","article-title":"Brazilian guidelines for the diagnosis of narcolepsy","volume":"32","author":"Al\u00f3e F","year":"2010","journal-title":"Rev Bras Psiquiatr"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.smrv.2005.03.004","article-title":"Symptomatic narcolepsy, cataplexy and hypersomnia, and their implications in the hypothalamic hypocretin\/orexin system","volume":"9","author":"Nishino S","year":"2005","journal-title":"Sleep Med Rev"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.conb.2013.04.013","article-title":"The autoimmune basis of narcolepsy","volume":"23","author":"Mahlios J","year":"2013","journal-title":"Curr Opin Neurobiol"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","DOI":"10.1007\/s11910-015-0546-0","article-title":"Sleep disorders in multiple sclerosis: review","volume":"15","author":"Veauthier C","year":"2015","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"1-2","key":"ref5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jns.2012.07.025","article-title":"A patient with both narcolepsy and multiple sclerosis in association with Pandemrix vaccination","volume":"321","author":"Vrethem M","year":"2012","journal-title":"J Neurol Sci"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.sleep.2008.03.009","article-title":"Narcolepsy-like syndrome in multiple sclerosis","volume":"10","author":"Vetrugno R","year":"2009","journal-title":"Sleep Med"},{"key":"ref7","series-title":"International classification of sleep disorders","year":"2014","edition":"3rd"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1212\/WNL.37.4.693","article-title":"Clinical and sleep laboratory study of narcoleptic symptoms in multiple sclerosis","volume":"37","author":"Poirier G","year":"1987","journal-title":"Neurology"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1177\/1352458514564486","article-title":"A systematic review of the incidence and prevalence of sleep disorders and seizure disorders in multiple sclerosis","volume":"21","author":"Marrie RA","year":"2015","journal-title":"Mult Scler"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.sleep.2013.03.015","article-title":"A patient with narcolepsy with cataplexy and multiple sclerosis: two different diseases that may share pathophysiologic mechanisms?","volume":"14","author":"Peraita-Adrados R","year":"2013","journal-title":"Sleep Med"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v75n6\/0004-282X-anp-75-06-0345.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T23:01:26Z","timestamp":1498345286000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2017000600345&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0004-282X2017000600345"],"URL":"https:\/\/doi.org\/10.1590\/0004-282x20170063","relation":{},"ISSN":["0004-282X"],"issn-type":[{"value":"0004-282X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}