{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:36:04Z","timestamp":1778038564865,"version":"3.51.4"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>ABSTRACT Congenital Zika syndrome is an emergent cause of a congenital infectious disorder, resulting in severe damage to the central nervous system and microcephaly. Despite advances in understanding the pathophysiology of the disease, we still do not know all the mechanisms enrolled in the vertical transmission of the virus. As has already been reported in other types of congenital infectious disorders in dizygotic twin pregnancies, it is possible that the virus affects only one of the fetuses. In this article, we report on two cases of twin pregnancies exposed to the Zika virus, but with only one of the fetuses affected with microcephaly and brain damage. This indicates the urgent need for more studies regarding the pathophysiology of viral infection and the mechanisms involved in the natural protection against the virus.<\/jats:p>","DOI":"10.1590\/0004-282x20170066","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T17:55:02Z","timestamp":1498240502000},"page":"381-386","source":"Crossref","is-referenced-by-count":35,"title":["Discordant clinical outcomes of congenital Zika virus infection in twin pregnancies"],"prefix":"10.1590","volume":"75","author":[{"given":"Vanessa van der","family":"Linden","sequence":"first","affiliation":[{"name":"Hospital Bar\u00e3o de Lucena, Brasil; Associa\u00e7\u00e3o de Assist\u00eancia \u00e0 Crian\u00e7a Deficiente, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9lio van der","family":"Linden Junior","sequence":"additional","affiliation":[{"name":"Centro de Reabilita\u00e7\u00e3o Dr. Henrique Santillo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana de Carvalho","family":"Leal","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco, Brasil; 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