{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:41:50Z","timestamp":1784770910126,"version":"3.55.0"},"reference-count":31,"publisher":"FapUNIFESP (SciELO)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"abstract":"<jats:p>ABSTRACT The new epidemic of Zika virus infection raises grave concerns, especially with the increasingly-recognized link between emerging cases of microcephaly and this infectious disease. Besides small cranial dimensions, there are striking morphologic anomalies in the fetal brain. Key anomalies include cortical developmental malformations and a peculiar distribution of pathologic calcifications. These potentially indicate a new pattern of congenital central nervous system infection.  Methods: Eight women underwent fetal MRI. Four infants also underwent postnatal CT. Five of the women underwent amniocentesis.  Results: All neonates were born with microcephaly. On fetal MRI, ventriculomegaly, marked reduction of white matter thickness, severe sylvian fissure simplification, abnormal sulcation, and diffuse volumetric loss of cerebellar hemispheres were consistently seen. On postnatal CT, diffuse subcortical and basal ganglia calcifications were observed. The Zika virus was detected in two amniocenteses by polymerase chain reaction assays.  Conclusion: We hope to assist the medical community in recognizing the spectrum of encephalic changes related to congenital Zika virus infection.<\/jats:p>","DOI":"10.1590\/0004-282x20170134","type":"journal-article","created":{"date-parts":[[2017,11,18]],"date-time":"2017-11-18T17:19:56Z","timestamp":1511025596000},"page":"703-710","source":"Crossref","is-referenced-by-count":18,"title":["Presumed Zika virus-related congenital brain malformations: the spectrum of CT and MRI findings in fetuses and newborns"],"prefix":"10.1590","volume":"75","author":[{"given":"Jos\u00e9 Daniel Vieira de","family":"Castro","sequence":"first","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licia Pacheco","family":"Pereira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Aguiar","family":"Dias","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindenberg Barbosa","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanira Costa Nogueira","family":"Maia","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus Irajacy Fernandes da","family":"Costa","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline Campos Monteiro de","family":"Castro","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Edson de Lucena","family":"Feitosa","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Herl\u00e2nio Costa","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2017,10]]},"reference":[{"key":"ref1","series-title":"WHO statement on the first meeting of the International Health Regulations (2005) (IHR 2005) Emergency Committee on Zika virus and observed increase in neurological disorders and neonatal malformations","year":"2016"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3201\/eid1802.111224","article-title":"Zika virus infection, Cambodia, 2010","volume":"18","author":"Heang V","year":"2012","journal-title":"Emerg Infect Dis."},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4269\/ajtmh.15-0022","article-title":"Detection of Zika Virus Infection in Thailand, 2012-2014","volume":"93","author":"Buathong R","year":"2015","journal-title":"Am J Trop Med Hyg."},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1056\/NEJMp1600297","article-title":"Zika virus in the Americas: yet another arbovirus threat","volume":"374","author":"Fauci AS","year":"2016","journal-title":"N Engl J Med."},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1590\/0074-02760160085","article-title":"Zika virus damages the human placental barrier and presents marked fetal neurotropism","volume":"111","author":"De Noronha L","year":"2016","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz."},{"issue":"24","key":"ref6","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1056\/NEJMoa0805715","article-title":"Zika virus outbreak on Yap Island, Federated States of Micronesia","volume":"360","author":"Duffy MR","year":"2009","journal-title":"N Engl J Med."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S1473-3099(16)00096-7","article-title":"Zika virus: time to move from case reports to case control","volume":"16","author":"Musso D.","year":"2016","journal-title":"Lancet Infect. 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