{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:21:54Z","timestamp":1780507314459,"version":"3.54.1"},"reference-count":10,"publisher":"FapUNIFESP (SciELO)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>ABSTRACT Mary Broadfoot Walker was a Scottish physician who, in 1935, described in great detail the effect of an anticholinesterase drug (physostigmine) on the signs and symptoms of myasthenia gravis. An original five-minutes movie is available online and the skepticism of her contemporary British medical doctors is understandable when the drastic effect of the treatment is shown in this movie. What Mary Walker taught us, more than eight decades ago, about myasthenia gravis continues to be the basis of a pharmacological diagnostic test and treatment of this disease.<\/jats:p>","DOI":"10.1590\/0004-282x20170138","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T17:29:07Z","timestamp":1512581347000},"page":"825-826","source":"Crossref","is-referenced-by-count":4,"title":["Mary Broadfoot Walker: 83 years since a historical discovery"],"prefix":"10.1590","volume":"75","author":[{"given":"Vitor Martinez de","family":"Carvalho","sequence":"first","affiliation":[{"name":"Universidade Metropolitana de Santos, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo de Almeida Guimar\u00e3es","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Universidade Metropolitana de Santos, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleysson Rodrigues","family":"Rosa","sequence":"additional","affiliation":[{"name":"Harvard Medical School, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara Dadalti","family":"Fragoso","sequence":"additional","affiliation":[{"name":"Universidade Metropolitana de Santos, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0072-9752(08)02154-4","article-title":"The Discovery of neurotransmitters and applications to neurology","volume":"95","author":"Sourkes TL","year":"2010","journal-title":"Handb Clin Neurol."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/S0140-6736(00)94294-6","article-title":"Treatment of myasthenia gravis with physostigmine","author":"Walker MB","year":"1934","journal-title":"The Lancet"},{"issue":"6","key":"ref3","first-page":"759","article-title":"Case showing the effect of prostigmin on myasthenia gravis","volume":"28","author":"Walker MB","year":"1935","journal-title":"Proc R Soc Med."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1515\/romneu-2017-0011","article-title":"The miracle of St. Alfege's Hospital and the history of the treatment of myasthenia gravis","volume":"1","author":"Croitoru C","year":"2017","journal-title":"Rom Neurosurg."},{"key":"ref5","series-title":"1935 Prostigmin demonstration for MG","year":"2007"},{"issue":"5857","key":"ref6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/bmj.2.5857.42","article-title":"Some discoveries on myasthenia gravis: the background","volume":"2","author":"Walker MB","year":"1973","journal-title":"Br Med J."},{"key":"ref7","first-page":"47","article-title":"Observations on a case of familial periodic paralysis","volume":"3","author":"Aitken RS","year":"1937","journal-title":"Clin Sci."},{"key":"ref8","series-title":"Why Michael couldn't hit: and other tales of the neurology of sports","author":"Klawans Harold L.","year":"1996"},{"issue":"2","key":"ref9","first-page":"108","article-title":"The miracle of St. Alfege's: discovering a treatment for myaesthenia gravis","volume":"100","author":"Lee MR","year":"2007","journal-title":"J Royal Soc Med."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000084268","article-title":"Mary Broadfoot Walker (1888-1974): a historic discovery in myasthenia gravis","volume":"53","author":"Pearce JMS","year":"2005","journal-title":"Eur Neurol."}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v75n11\/0004-282X-anp-75-11-0825.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T12:04:09Z","timestamp":1570449849000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2017001100825&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S0004-282X2017001100825"],"URL":"https:\/\/doi.org\/10.1590\/0004-282x20170138","relation":{},"ISSN":["1678-4227","0004-282X"],"issn-type":[{"value":"1678-4227","type":"electronic"},{"value":"0004-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]}}}