{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:06:22Z","timestamp":1767859582280,"version":"3.49.0"},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>ABSTRACT  Objectives  To describe anticoagulation characteristics in patients with cardiac complications from Chagas disease and compare participants with and without cardioembolic ischemic stroke (CIS).  Methods  A retrospective cohort of patients with Chagas disease, using anticoagulation, conducted from January 2011 to December 2014.  Results  Forty-two patients with Chagas disease who were using anticoagulation were studied (age 62.9\u00b112.4 years), 59.5% female and 47.6% with previous CIS, 78.6% with non-valvular atrial fibrillation and 69.7% with dilated cardiomyopathy. Warfarin was used in 78.6% of patients and dabigatran (at different times) in 38%. In the warfarin group, those with CIS had more medical appointments per person-years of follow-up (11.7 vs 7.9), a higher proportion of international normalized ratios within the therapeutic range (57% vs 42% medical appointments, p = 0.025) and an eight times higher frequency of minor bleeding (0.64 vs 0.07 medical appointments).  Conclusion  Patients with Chagas disease and previous CIS had better control of INR with a higher frequency of minor bleeding.<\/jats:p>","DOI":"10.1590\/0004-282x20170180","type":"journal-article","created":{"date-parts":[[2018,1,21]],"date-time":"2018-01-21T00:00:41Z","timestamp":1516492841000},"page":"22-25","source":"Crossref","is-referenced-by-count":9,"title":["Anticoagulation in patients with cardiac manifestations of Chagas disease and cardioembolic ischemic stroke"],"prefix":"10.1590","volume":"76","author":[{"given":"Jean M.C.","family":"Monteiro","sequence":"first","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel L.","family":"San-Martin","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz C.G.","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro A.P. de","family":"Jesus","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil; Universidade Federal da Bahia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamary","family":"Oliveira Filho","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brasil; Universidade Federal da Bahia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"1","article-title":"Control of Chagas\u2019 disease: report of a WHO Expert Committee","volume":"905","year":"2002","journal-title":"World Health Organ Tech Rep Ser"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000069893","article-title":"Stroke and ischemic heart disease mortality trends in Brazil from 1979 to 1996","volume":"22","author":"Mansur AP","year":"2003","journal-title":"Neuroepidemiology"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1056\/NEJMra1410150","article-title":"Chagas\u2019 fisease","volume":"373","author":"Longo DL","year":"2015","journal-title":"N Engl J Med"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1136\/jnnp.74.4.516","article-title":"American trypanosomiasis (Chagas\u2019 disease): an unrecognised cause of stroke","volume":"74","author":"Carod-Artal FJ","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1161\/01.STR.0000177866.13451.e4","article-title":"Chagas disease Is an independent risk factor for stroke baseline characteristics of a Chagas disease cohort","volume":"36","author":"Oliveira Filho J","year":"2005","journal-title":"Stroke"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1161\/01.STR.0000163104.92943.50","article-title":"Chagasic cardiomyopathy is independently associated with ischemic stroke in Chagas disease","volume":"36","author":"Carod-Artal FJ","year":"2005","journal-title":"Stroke"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1161\/STROKEAHA.109.560854","article-title":"Chagas disease: independent risk factor for stroke","volume":"40","author":"Paix\u00e3o LC","year":"2009","journal-title":"Stroke"},{"issue":"1-2","key":"ref8","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jns.2008.12.015","article-title":"Ischemic cerebrovascular events in patients with Chagas cardiomyopathy: a prospective follow-up study","volume":"278","author":"Nunes MCP","year":"2009","journal-title":"Journal of the Neurological Sciences"},{"issue":"5","key":"ref9","first-page":"306","article-title":"Prevention strategies of cardioembolic ischemic stroke in Chagas\u2019 disease","volume":"91","author":"Sousa AS","year":"2008","journal-title":"Arq Bras Cardiol"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1161\/01.STR.0000208294.46968.a4","article-title":"Use and effectiveness of warfarin in Medicare beneficiaries with atrial fibrillation","volume":"37","author":"Birman-Deych E","year":"2006","journal-title":"Stroke"},{"issue":"21","key":"ref11","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1161\/CIRCULATIONAHA.106.653048","article-title":"Major hemorrhage and tolerability of warfarin in the first year of therapy among elderly patients with atrial fibrillation","volume":"115","author":"Hylek EM","year":"2007","journal-title":"Circulation"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa0905561","article-title":"Dabigatran versus Warfarin in Patients with Atrial Fibrillation","volume":"361","author":"Connolly SJ","year":"2009","journal-title":"N Engl J Med"},{"issue":"7","key":"ref13","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1161\/STROKEAHA.113.000990","article-title":"Dabigatran versus Warfarin: effects on ischemic and hemorrhagic strokes and bleeding in Asians and Non-Asians with atrial fibrillation","volume":"44","author":"Hori M","year":"2013","journal-title":"Stroke"},{"issue":"13","key":"ref14","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1056\/NEJMoa1300615","article-title":"Dabigatran versus Warfarin in patients with mechanical heart valves","volume":"369","author":"Eikelboom JW","year":"2013","journal-title":"N Engl J Med"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00228-012-1411-6","article-title":"Agreement among four drug information sources for the occurrence of warfarin drug interactions in Brazilian heart disease patients with a high prevalence of Trypanosomacruzi infection","volume":"69","author":"Martins MA","year":"2013","journal-title":"Eur J Clin Pharmacol"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v76n1\/0004-282X-anp-76-1-0022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,21]],"date-time":"2018-01-21T00:00:44Z","timestamp":1516492844000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2018000100022&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0004-282X2018000100022"],"URL":"https:\/\/doi.org\/10.1590\/0004-282x20170180","relation":{},"ISSN":["1678-4227","0004-282X"],"issn-type":[{"value":"1678-4227","type":"electronic"},{"value":"0004-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}