{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:06:28Z","timestamp":1790762788055,"version":"4.1.0"},"reference-count":33,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>ABSTRACT In this study, the effect of thymoquinone (TQ) on propylthiouracil (PTU)-induced memory impairment was investigated in juvenile rats. The rats were grouped into control, Hypo, Hypo-TQ5 and Hypo-TQ10. Propylthiouracil increased latency time in the Morris water maze test and decreased delay in entering the dark compartment in the passive avoidance test. Both 5 mg\/kg and 10 mg\/kg doses of TQ decreased latency time in the Morris water maze test and increased delay in entering the dark compartment in a passive avoidance test. The PTU also increased malondialdehyde and nitric oxide metabolites in the brain while reduced the thiol content and superoxide dismutase and catalase activities and serum T4 level. Both doses of TQ decreased malondialdehyde and nitric oxide metabolites in the brain while enhanced the thiol content and superoxide dismutase and catalase activities and serum T4 level. The results of the present study showed that TQ protected against PTU-induced memory impairments in rats.<\/jats:p>","DOI":"10.1590\/0004-282x20170182","type":"journal-article","created":{"date-parts":[[2018,1,21]],"date-time":"2018-01-21T00:00:51Z","timestamp":1516492851000},"page":"32-40","source":"Crossref","is-referenced-by-count":46,"title":["Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats"],"prefix":"10.1590","volume":"76","author":[{"given":"Yousef","family":"Baghcheghi","sequence":"first","affiliation":[{"name":"Mashhad University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Mashhad University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farimah","family":"Beheshti","sequence":"additional","affiliation":[{"name":"Torbat Heydariyeh University of 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IM","year":"1998","journal-title":"Thyroid"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2202-11-50","article-title":"Developmental iodine deficiency and hypothyroidism impair neural development in rat hippocampus: involvement of doublecortin and NCAM-180","volume":"11","author":"Gong J","year":"2010","journal-title":"BMC Neurosci"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2202-11-50","article-title":"Developmental iodine deficiency and hypothyroidism impair neural development in rat hippocampus: involvement of doublecortin and NCAM-180","volume":"11","author":"Gong J","year":"2010","journal-title":"BMC Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.brainres.2009.02.043","article-title":"The maintenance of hippocampal pyramidal neuron populations is dependent on the modulation of specific cell cycle regulators by thyroid hormones","volume":"1271","author":"Alva-S\u00e1nchez 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Res"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0168-0102(01)00237-1","article-title":"Hypothyroidism in the developing rat brain is associated with marked oxidative stress and aberrant intraneuronal accumulation of neurofilaments","volume":"40","author":"Rahaman SO","year":"2001","journal-title":"Neurosci Res"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1590\/S1807-59322010001100021","article-title":"Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth","volume":"65","author":"Hosseini M","year":"2010","journal-title":"Clinics"},{"issue":"1-3","key":"ref11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejphar.2013.01.036","article-title":"Inhibition of brain oxidative stress and inducible nitric oxide synthase expression by thymoquinone attenuates the development of morphine tolerance and dependence in 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