{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:39:53Z","timestamp":1789990793451,"version":"4.0.1"},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"abstract":"<jats:p>ABSTRACT Motor and non-motor manifestations are common and disabling features of hereditary spastic paraplegia (HSP). Botulinum toxin type A (Btx-A) is considered effective for spasticity and may improve gait in these patients. Little is known about the effects of Btx-A on non-motor symptoms in HSP patients.  Objective To assess the efficacy of Btx-A on motor and non-motor manifestations in HSP patients.  Methods Thirty-three adult patients with a clinical and molecular diagnosis of HSP were evaluated before and after Btx-A injections.  Results Mean age was 41.7 \u00b1 13.6 years and there were 18 women. Most patients had a pure phenotype and SPG4 was the most frequent genotype. The Btx-A injections resulted in a decrease in spasticity at the adductor muscles, and no other motor measure was significantly modified. In contrast, fatigue scores were significantly reduced after Btx-A injections.  Conclusion Btx-A injections resulted in no significant functional motor improvement for HSP, but fatigue improved after treatment.<\/jats:p>","DOI":"10.1590\/0004-282x20180013","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T20:03:25Z","timestamp":1521921805000},"page":"183-188","source":"Crossref","is-referenced-by-count":21,"title":["Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations"],"prefix":"10.1590","volume":"76","author":[{"given":"Katiane R.","family":"Servelhere","sequence":"first","affiliation":[{"name":"Universidade Estadual de Campinas,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Faber","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Martinez","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Nickel","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Moro","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco M. 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Medical Research Council: Nerve Injuries Research Committee. His Majesty's Stationery Office: 1942; pp. 48 (iii) and 74 figures and 7 diagrams; with aids to the examination of the peripheral nervous system. By Michael O'Brien for the Guarantors of Brain. 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