{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:23:09Z","timestamp":1778685789913,"version":"3.51.4"},"reference-count":31,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"abstract":"<jats:p>ABSTRACT Neurocysticercosis (NCC) is one of the parasitic infections that most affects the central nervous system. The knowledge regarding its immunopathogenesis and pathophysiology needs broadening. Taenia crassiceps cysticerci are used as the NCC experimental model. The aim of this work was to describe the general pathological processes and the in situ cytokine profile in C57BL\/6 mice inoculated intracranially with viable T. crassiceps cysticerci. The histopathology analysis showed cysticerci in the extraparenchymal and intraventricular region, mononuclear inflammatory infiltration surrounding the parasite, microgliosis and meningitis. The analysis of the in situ immune profiles showed a predominance of the Th2 response. The IL-4 and IL-10 dosages were significantly increased in the infected group. The decrease in the INF-gamma dosage reflects the immunomodulation from the cysticerci. In conclusion, a T. crassiceps NCC infection in C57BL\/6 mice triggers an inflammatory response, a predominance of Th2 type in situ profile, with mononuclear inflammatory cell infiltration, meningitis and microgliosis.<\/jats:p>","DOI":"10.1590\/0004-282x20180032","type":"journal-article","created":{"date-parts":[[2018,6,9]],"date-time":"2018-06-09T19:02:52Z","timestamp":1528570972000},"page":"339-345","source":"Crossref","is-referenced-by-count":4,"title":["Histopathologic aspects of experimental cysticercosis and in situ cytokines profile in C57BL\/6 mice"],"prefix":"10.1590","volume":"76","author":[{"given":"An\u00e1lia Cirqueira","family":"Milhomem","sequence":"first","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Juliana Soaris de","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidelberto Matos","family":"Silva","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Gurupi, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Clare","family":"Vinaud","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton Adriano Pelli de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Reis","family":"Machado","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruy de Souza","family":"Lino J\u00fanior","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,5]]},"reference":[{"issue":"4","key":"ref1","article-title":"Neurocysticercosis-more than a neglected disease","volume":"7","author":"Nash TE","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref2","series-title":"WHO 2011. Report of the WHO Expert Consultation on Foodborne Trematode Infections and Taeniasis\/Cysticercosis, 2009 Oct 12-16; Vientiane, Lao People's Democratic Republic","year":"2011"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/S0031182010000272","article-title":"Taenia solium: current understanding of laboratory animal models of taeniosis","volume":"137","author":"Flisser A","year":"2010","journal-title":"Parasitology"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/S1474-4422(14)70094-8","article-title":"Clinical symptoms, diagnosis, and treatment of neurocysticercosis","volume":"13","author":"Garcia HH","year":"2014","journal-title":"Lancet Neurol"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1365-3024.2007.00967.x","article-title":"The immune response in Taenia solium cysticercosis: protection and injury","volume":"29","author":"Sciutto E","year":"2007","journal-title":"Parasite Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2147\/IJGM.S73249","article-title":"Managing neurocysticercosis: challenges and solutions","volume":"8","author":"Fogang YF","year":"2015","journal-title":"Int J Gen Med."},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"995","DOI":"10.4049\/jimmunol.162.2.995","article-title":"Development of an animal model for neurocysticercosis: immune response in the central nervous system is characterized by a predominance of \u03b3 \u03b4 T cells","volume":"162","author":"Cardona AE","year":"1999","journal-title":"J Immunol"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004143","article-title":"A comparative study of peripheral immune responses to Taenia soliumin individuals with parenchymal and subarachnoid neurocysticercosis","volume":"9","author":"Tuero I","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/pim.12299","article-title":"Immunopathology in Taenia solium neurocysticercosis","volume":"38","author":"Fleury A","year":"2016","journal-title":"Parasite Immunol"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri1130","article-title":"Three or more routes for leukocyte migration into the central nervous system","volume":"3","author":"Ransohoff RM","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/B978-0-7020-4088-7.00097-3","article-title":"Neurocysticercosis","volume":"121","author":"Del Brutto OH","year":"2014","journal-title":"Handb Clin Neurol"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.clineuro.2012.12.026","article-title":"Isolated brainstem cysticercosis: a review","volume":"115","author":"Del Brutto OH","year":"2013","journal-title":"Clin Neurol Neurosurg"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijpara.2011.11.009","article-title":"Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immunoinflammatory parameters","volume":"42","author":"C\u00e1rdenas G","year":"2012","journal-title":"Int J Parasitol"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"354","DOI":"10.4269\/ajtmh.1997.57.354","article-title":"Immunoblot with cerebrospinal fluid from patients with neurocysticercosis using antigen from cysticerci of Taenia solium and Taenia crassiceps","volume":"57","author":"Vaz AJ","year":"1997","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1017\/S0031182015001572","article-title":"Cellular immune response in intraventricular experimental neurocysticercosis","volume":"143","author":"Moura VB","year":"2016","journal-title":"Parasitology"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1590\/S0004-282X2012005000010","article-title":"Experimental encephalitis caused by Taenia crassiceps cysticerci in mice","volume":"70","author":"Matos-Silva H","year":"2012","journal-title":"Arq Neuropsiquiatr"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/j.ajpath.2015.04.015","article-title":"Novel rat model for neurocysticercosis using Taenia solium","volume":"185","author":"Verastegui MR","year":"2015","journal-title":"Am J Pathol"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003980","article-title":"Taenia solium: development of an experimental model of porcine neurocysticercosis","volume":"9","author":"Fleury A","year":"2015","journal-title":"PLoS Negl Trop 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AA","year":"2012","journal-title":"J Comp Pathol."},{"issue":"0","key":"ref22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1590\/S1678-9946201658055","article-title":"EXPERIMENTAL SUBCUTANEOUS CYSTICERCOSIS BY Taenia crassiceps IN BALB\/c AND C57BL\/6 MICE","volume":"58","author":"Pereira \u00cdM","year":"2016","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/expr.2000.4523","article-title":"Leishmania sp: comparative study with Toxoplasma gondii and Trypanosoma cruzi in their ability to initialize IL-12 and IFN-\u03b3 synthesis","volume":"95","author":"Oliveira MA","year":"2000","journal-title":"Exp Parasitol"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"686","DOI":"10.3171\/jns.1987.66.5.0686","article-title":"Hydrocephalus secondary to cysticercotic arachnoiditis. A long-term follow-up review of 92 cases","volume":"66","author":"Sotelo J","year":"1987","journal-title":"J Neurosurg"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1590\/S0004-282X2012000400002","article-title":"Cysticercosis and the immunossupression: what are the mechanisms involved?","volume":"70","author":"Bueno EC","year":"2012","journal-title":"Arq Neuropsiquiatr"},{"issue":"12","key":"ref26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004207","article-title":"Inflammation caused by praziquantel treatment depends on the location of the Taenia solium cysticercus in porcine neurocysticercosis","volume":"9","author":"Cangalaya C","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1600-065X.1997.tb00967.x","article-title":"A vision of cell death: insights into immune privilege","volume":"156","author":"Ferguson TA","year":"1997","journal-title":"Immunol Rev"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1182\/blood.V96.10.3569","article-title":"Extensive genetic alterations of the HLA region, including homozygous deletions of HLA class II genes in B-cell lymphomas arising in immune-privileged sites","volume":"96","author":"Riemersma SA","year":"2000","journal-title":"Blood"},{"key":"ref29","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/320519","article-title":"Immune privilege as an intrinsic CNS property: astrocytes protect the CNS against T-cell-mediated neuroinflammation","volume":"2013","author":"Gimsa U","year":"2013","journal-title":"Mediators Inflamm"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2174\/156802608783790848","article-title":"The complex role of pro- and anti-inflammatory cytokines in cysticercosis: immunological lessons from experimental and natural hosts","volume":"8","author":"Terrazas LI","year":"2008","journal-title":"Curr Top Med Chem"},{"issue":"1-3","key":"ref31","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12026-009-8150-5","article-title":"Cell type-specific regulation of IL-10 expression in inflammation and disease","volume":"47","author":"Hedrich CM","year":"2010","journal-title":"Immunol Res."}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v76n5\/0004-282X-anp-76-05-0339.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T03:23:58Z","timestamp":1693711438000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2018000500339&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,5]]}},"alternative-id":["S0004-282X2018000500339"],"URL":"https:\/\/doi.org\/10.1590\/0004-282x20180032","relation":{},"ISSN":["1678-4227","0004-282X"],"issn-type":[{"value":"1678-4227","type":"electronic"},{"value":"0004-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]}}}