{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,26]],"date-time":"2023-11-26T12:49:17Z","timestamp":1701002957947},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"abstract":"<jats:p>ABSTRACT  Objective: To determine whether serum levels of anti-acetylcholine receptor antibody (anti-AChR-Abs) are related to clinical parameters of blepharospasm (BSP).  Methods: Eighty-three adults with BSP, 60 outpatients with hemifacial spasm (HFS) and 58 controls were recruited. Personal history, demographic factors, response to botulinum toxin type A (BoNT-A) and other neurological conditions were recorded. Anti-AChR-Abs levels were quantified using an enzyme-linked immunosorbent assay.  Results: The anti-AChR Abs levels were 0.237 \u00b1 0.022 optical density units in the BSP group, which was significantly different from the HFS group (0.160 \u00b1 0.064) and control group (0.126 \u00b1 0.038). The anti-AChR Abs level was correlated with age and the duration of response to the BoNT-A injection.  Conclusion: Patients with BSP had an elevated anti-AChR Abs titer, which suggests that dysimmunity plays a role in the onset of BSP. An increased anti-AChR Abs titer may be a predictor for poor response to BoNT-A in BSP.<\/jats:p>","DOI":"10.1590\/0004-282x20180076","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T06:07:09Z","timestamp":1537078029000},"page":"522-526","source":"Crossref","is-referenced-by-count":2,"title":["Blepharospasm with elevated anti-acetylcholine receptor antibody titer"],"prefix":"10.1590","volume":"76","author":[{"given":"Min","family":"Tang","sequence":"first","affiliation":[{"name":"Zhejiang University School of Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Li","sequence":"additional","affiliation":[{"name":"Tongde Hospital of Zhejiang Province,  P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangping","family":"He","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Ji","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanxia","family":"Meng","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,8]]},"reference":[{"issue":"8","key":"ref1","first-page":"646","article-title":"Benign essential blepharospasm","volume":"58","author":"Malinovsky V","year":"1987","journal-title":"J Am Optom Assoc"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.pharmthera.2006.03.005","article-title":"B cells in the pathophysiology of autoimmune neurological disorders: a credible therapeutic target","volume":"112","author":"Dalakas MC","year":"2006","journal-title":"Pharmacol Ther"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.ajem.2013.08.030","article-title":"Myasthenia gravis and Guillain-Barr\u00e9 cooccurrence syndrome","volume":"31","author":"Zhou C","year":"2013","journal-title":"Am J Emerg Med"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/CND.0b013e31824db163","article-title":"Amyotrophic lateral sclerosis with positive anti-acetylcholine receptor antibodies. 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