{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:01:23Z","timestamp":1793278883854,"version":"4.5.0"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"abstract":"<jats:p>ABSTRACT  Aims: To investigate hereditary spastic paraplegia (HSP) in a pediatric Brazilian sample.  Methods: Epidemiological, clinical, radiological and laboratory data were analyzed in 35 patients.  Results: Simple HSP (HSP-S) was detected in 12 patients, and complicated HSP (HSP-C) was detected in 23 patients. The mean age of onset of symptoms was 2.9 years in HSP-S and 1.6 years in HSP-C (p = 0.023). The disease was more severe in HSP-C. There were no differences in sex, ethnic background, or family history between groups. Intellectual disability was the most frequent finding associated with HSP-C. Peripheral axonal neuropathy was found in three patients. In the HSP-C group, MRI was abnormal in 13 patients. The MRI abnormalities included nonspecific white matter lesions, cerebellar atrophy, thinning of the corpus callosum and the \u201cear of the lynx sign\u201d.  Conclusions: In children with spastic paraplegia, HSP must be considered whenever similar pathologies, mainly diplegic cerebral palsy, are ruled out.<\/jats:p>","DOI":"10.1590\/0004-282x20180153","type":"journal-article","created":{"date-parts":[[2019,2,9]],"date-time":"2019-02-09T13:20:33Z","timestamp":1549718433000},"page":"10-18","source":"Crossref","is-referenced-by-count":9,"title":["Hereditary spastic paraplegia: a clinical and epidemiological study of a Brazilian pediatric population"],"prefix":"10.1590","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4323-7916","authenticated-orcid":false,"given":"Roberta Paiva Magalh\u00e3es","family":"Ortega","sequence":"first","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio","family":"Rosemberg","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brasil; Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2019,1]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1469-8749.1991.tb14881.x","article-title":"\u2018Pure\u2019 and \u2018complicated\u2019 forms of hereditary spastic paraplegia presenting in childhood","volume":"33","author":"Appleton RE","year":"1991","journal-title":"Dev Med Child Neurol"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000358801","article-title":"The global epidemiology of hereditary ataxia and spastic paraplegia: a systematic review of prevalence studies","volume":"42","author":"Ruano L","year":"2014","journal-title":"Neuroepidemiology"},{"key":"ref3","series-title":"Hereditary spastic paraplegia overview. 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