{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:55:39Z","timestamp":1775148939730,"version":"3.50.1"},"reference-count":14,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"abstract":"<jats:p>ABSTRACT Syphilis is a re-emerging sexually-transmitted infection, caused by the spirochete Treponema pallidum, that may penetrate early into the central nervous system. The venereal disease research laboratory test (VDRL) on the cerebrospinal fluid (CSF) is the most widely used for neurosyphilis diagnosis. We evaluated the performance of two other nontreponemal tests (rapid plasma reagin [RPR] and unheated serum reagin [USR] tests) in comparison with the VDRL in CSF.  Methods: We analyzed CSF samples from 120 individuals based on VDRL reactivity in the CSF and the clinical picture of neurosyphilis.  Results: High inter-rater reliability was found among all three tests, with equivalent sensitivity and specificity. Intraclass correlation coefficient for absolute agreement was 1 for VDRL versus USR, 0.99 for VDRL versus RPR, and 0.99 for RPR versus USR.  Conclusions: Rapid plasma reagin and unheated serum reagin tests were identified as excellent alternatives for neurosyphilis diagnosis.<\/jats:p>","DOI":"10.1590\/0004-282x20180155","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T13:26:27Z","timestamp":1550841987000},"page":"91-95","source":"Crossref","is-referenced-by-count":8,"title":["A comparison of nontreponemal tests in cerebrospinal fluid for neurosyphilis diagnosis: equivalent detection of specific antibodies"],"prefix":"10.1590","volume":"77","author":[{"given":"Isadora","family":"Versiani","sequence":"first","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro Jorge","family":"Cabral-Castro","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6007-9142","authenticated-orcid":false,"given":"Marzia","family":"Puccioni-Sohler","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro,  Brasil; Universidade Federal do Rio de Janeiro,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019,2]]},"reference":[{"key":"ref1","series-title":"Handbook of clinical neurology","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/B978-0-7020-4088-7.00098-5","volume-title":"Neurosyphilis","author":"Berger J","year":"2014"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s11908-015-0481-x","article-title":"Neurosyphilis update: atypical is the new typical","volume":"17","author":"Bhai S","year":"2015","journal-title":"Curr Infect Dis Rep."},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1172\/JCI57173","article-title":"Syphilis: using modern approaches to understand an old disease","volume":"121","author":"Ho EL","year":"2011","journal-title":"J Clin Invest."},{"key":"ref4","series-title":"Secretaria de Vigil\u00e2ncia em Sa\u00fade, Departamento de Vigil\u00e2ncia, Preven\u00e7\u00e3o e Controle das Doen\u00e7as Sexualmente Transmiss\u00edveis, AIDS e Hepatites Virais. Manual t\u00e9cnico para diagn\u00f3stico da s\u00edfilis","year":"2016"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1001\/jama.290.11.1510","article-title":"Update on syphilis: resurgence of an old problem","volume":"290","author":"Golden MR","year":"2003","journal-title":"JAMA."},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/OLQ.0b013e31824b1cde","article-title":"The rapid plasma reagin test cannot replace the venereal disease research laboratory test for neurosyphilis diagnosis","volume":"39","author":"Marra CM","year":"2012","journal-title":"Sex Transm Dis."},{"key":"ref7","series-title":"Syphilis: a provider's guide to treatment and prevention","year":"2017"},{"key":"ref8","first-page":"1714","article-title":"Neurosyphilis","volume":"216","author":"Marra CM","year":"2015","journal-title":"Continuum (Minneap Minn)."},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000347109","article-title":"Clinical spectrum of neurosyphilis among HIV-negative patients in the modern era","volume":"226","author":"Zhang HL","year":"2013","journal-title":"Dermatology."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cca.2016.10.018","article-title":"Macrophage migration inhibitory factor as a novel cerebrospinal fluid marker for neurosyphilis among HIV-negative patients","volume":"463","author":"Lin LR","year":"2016","journal-title":"Clin Chim Acta."},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/OLQ.0b013e31824ee574","article-title":"Treponemal tests for neurosyphilis: less accurate than what we thought?","volume":"39","author":"Ho EL","year":"2012","journal-title":"Sex Transm Dis."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cca.2016.11.031","article-title":"Re-evaluating the sensitivity of the rabbit infectivity test for Treponema pallidum in modern era","volume":"464","author":"Tong ML","year":"2017","journal-title":"Clin Chim Acta."},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/jcla.20254","article-title":"Nontreponemal tests in the diagnosis of neurosyphilis: an evaluation of the Venereal Disease Research Laboratory (VDRL) and the Rapid Plasma Reagin (RPR) tests","volume":"22","author":"Castro R","year":"2008","journal-title":"J Clin Lab Anal."},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1128\/JCM.02522-13","article-title":"Comparison of the cerebrospinal fluid (CSF) toluidine red unheated serum test and the CSF rapid plasma reagin test with the CSF venereal disease research laboratory test for diagnosis of neurosyphilis among HIV-negative syphilis patients in China","volume":"52","author":"Zhu L","year":"2014","journal-title":"J Clin Microbiol"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v77n2\/1678-4227-anp-77-02-0091.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T14:18:27Z","timestamp":1579875507000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2019000200091&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2]]}},"alternative-id":["S0004-282X2019000200091"],"URL":"https:\/\/doi.org\/10.1590\/0004-282x20180155","relation":{},"ISSN":["1678-4227","0004-282X"],"issn-type":[{"value":"1678-4227","type":"electronic"},{"value":"0004-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}